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Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
9 events found.

Pragmatic clinical trial

  1. Events
  2. Pragmatic clinical trial

Events

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  • May 2019

  • Thu 2

    NIH Workshop: Design & Analysis of Embedded Pragmatic Clinical Trials

    May 2, 2019 @ 8:00 am - 4:30 pm

    The NIH Health Care Systems Research Collaboratory is hosting a one-day workshop on the Design & Analysis of Embedded Pragmatic Clinical Trials (ePCTs) on May 2, 2019, in the Lister […]

  • August 2021

  • Fri 27

    Grand Rounds August 27: Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock: the DOREMI trial

    August 27, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Benjamin Hibbert, MD, PhD Clinician Scientist and Interventional Cardiologist University of Ottawa Heart Institute Topic: Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock: the DOREMI trial […]

  • September 2021

  • Fri 17

    Grand Rounds September 17: Population-based Outreach to Prevent Suicidal Behavior: A Pragmatic Randomized Trial

    September 17, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Gregory Simon, MD, MPH Senior Investigator Kaiser Permanente Washington Health Research Institute Susan M Shortreed, PhD Senior Investigator, Biostatistics Unit Kaiser Permanente Washington Health Research Institute Affiliate Professor, Department of Biostatistics University of Washington Topic: Population-based Outreach to Prevent Suicidal Behavior: A Pragmatic Randomized Trial Date: Friday, September 17, 2021, 1:00-2:00 p.m. ET Meeting […]

  • October 2021

  • Fri 22

    Grand Rounds October 22: The STAMP Trial: Increasing Engagement in Advance Care Planning and Lessons Learned from Partnering with Community Ambulatory Practices

    October 22, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Terri R. Fried, MD Section Chief, Geriatrics Professor of Medicine Yale School of Medicine Attending Physician VA Connecticut Healthcare System Topic: The STAMP Trial: Increasing Engagement in Advance Care […]

  • Fri 29

    Grand Rounds October 29: Embedding Pragmatic Trials into Emergency and Critical Care

    October 29, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Matthew W. Semler, MD, MSc Assistant Professor Vanderbilt University Medical Center Jonathan D. Casey, MD, MSc Assistant Professor Vanderbilt University Medical Center Topic: Embedding Pragmatic Trials into Emergency and […]

  • December 2021

  • Fri 3

    Grand Rounds December 3: Primary Care-Based Behavioral Treatment for Long Term Opioid Users with Chronic Pain: Primary Results and Lessons Learned from the PPACT Pragmatic Trial

    December 3, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Lynn DeBar, PhD MPH Senior Scientist Kaiser Permanente Washington Health Research Institute Seattle, WA Topic: Primary Care-Based Behavioral Treatment for Long Term Opioid Users with Chronic Pain: Primary Results […]

  • January 2022

  • Fri 28

    Grand Rounds January 28: EMBED Trial Results: Pragmatic Trial of User-Centered Clinical Decision Support to Implement Emergency Department-Initiated Buprenorphine for Opioid Use Disorder

    January 28, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Edward R Melnick, MD, MHS Associate Professor of Emergency Medicine, Yale School of Medicine Associate Professor of Biostatistics (Health Informatics), Yale School of Public Health Program Director, Yale-VA Clinical Informatics Fellowship Program Gail D’Onofrio, MD, MS Albert E. Kent Professor of Emergency Medicine Yale School of Medicine Professor of Public Health, Chronic Disease & […]

  • April 2022

  • Fri 1

    Grand Rounds April 1: ICD-Pieces: Improving Care for CKD, Diabetes and Hypertension in Health Systems (Miguel A. Vazquez, MD; George (Holt) Oliver, MD, PhD)

    April 1, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Miguel A. Vazquez, MD Professor of Medicine University of Texas Southwestern Medical Center Dallas, TX George (Holt) Oliver, MD, PhD Vice President Clinical Informatics Parkland Center for Clinical Innovation Dallas, TX   Topic: ICD-Pieces: Improving Care for CKD, Diabetes and Hypertension in Health Systems Date: Friday, April 1, 2022, 1:00-2:00 p.m. ET Meeting Info: […]

  • August 2022

  • Fri 12

    Grand Rounds August 12: Equitably Including Diverse Participants in Pragmatic Clinical Trials (Consuelo H. Wilkins, MD, MSCI)

    August 12, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Consuelo H. Wilkins, MD, MSCI Senior Vice President and Senior Associate Dean for Health Equity and Inclusive Excellence Professor of Medicine Vanderbilt University Medical Center   Topic: Equitably Including […]

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