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Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • June 2024

  • Fri 28

    Grand Rounds June 28, 2024: Using ChatGPT to Facilitate Truly Informed Medical Consent (Fatima N. Mirza, MD, MPH)

    June 28, 2024 @ 1:00 pm - 2:00 pm

    Speaker: Fatima N. Mirza, MD, MPH Chief Resident Department of Dermatology Warren Alpert Medical School of Brown University Title: Using ChatGPT to Facilitate Truly Informed Medical Consent Date: Friday, June […]

  • July 2024

  • Tue 9

    The Science of Partner Engagement in Research: Development and Validation of Evaluation Metrics

    July 9, 2024 @ 1:00 pm - 2:00 pm

    Melody S. Goodman, Ph.D. New York University School of Global Public Health Register for the webinar About the Webinar Partner engagement is a crucial part of participatory public health research, […]

  • Fri 12

    Grand Rounds July 12, 2024: Causal Estimands: Should We Ask Different Causal Questions in Randomized Trials and in the Observational Studies That Emulate Them? (Miguel Hernan, MD)

    July 12, 2024 @ 1:00 pm - 2:00 pm

    Speaker: Miguel Hernan, MD Professor of Biostatistics and Epidemiology CAUSALab Harvard T.H. Chan School of Public Health Title: Causal Estimands: Should We Ask Different Causal Questions in Randomized Trials and […]

  • Mon 15

    Virtual Workshop: Going From Zero to 100: Generating Evidence Through Pragmatic Research to Address Pressing Healthcare Issues

    Featured July 15, 2024 @ 1:00 pm - 4:00 pm

    The NIH Pragmatic Trials Collaboratory's virtual workshop will explore how to generate meaningful, actionable evidence through pragmatic research. Join the Videocast: https://videocast.nih.gov/watch=54927 Day 1: July 15, 1:00 pm–4:00 pm ET Phase […]

  • Tue 16

    Virtual Workshop: Going From Zero to 100: Generating Evidence Through Pragmatic Research to Address Pressing Healthcare Issues

    Featured July 16, 2024 @ 11:00 am - 3:30 pm

    The NIH Pragmatic Trials Collaboratory's virtual workshop will explore how to generate meaningful, actionable evidence through pragmatic research. Day 2 will feature a keynote by NIH Director Dr. Monica Bertagnolli. […]

  • Fri 19

    Grand Rounds July 19, 2024: Lessons From PRECIDENTD: A Pragmatic Comparative Effectiveness Trial (Brendan M Everett, MD, MPH; Deborah J. Wexler, MD, MSc)

    July 19, 2024 @ 1:00 pm - 2:00 pm

    Speakers: Brendan M. Everett, MD, MPH Associate Professor of Medicine Divisions of Cardiology and Preventive Medicine Brigham and Women's Hospital and Harvard Medical School Deborah J. Wexler, MD, MSc Associate […]

  • Fri 26

    Grand Rounds July 26, 2024: Interventions for Optimization of Guideline-Directed Medical Therapy (Gregg C. Fonarow, MD)

    July 26, 2024 @ 1:00 pm - 2:00 pm

    Speaker: Gregg C. Fonarow, MD, FACC, FAHA, FHFSA Eliot Corday Professor of Cardiovascular Medicine and Science Director, Ahmanson-UCLA Cardiomyopathy Center Codirector, UCLA Preventative Cardiology Program UCLA Division of Cardiology Title: […]

  • August 2024

  • Fri 2

    Grand Rounds August 2, 2024: Precision Health to Population Health: Opportunities and Challenges for Gene Editing Therapies (Adrian Hernandez, MD, MHS)

    August 2, 2024 @ 1:00 pm - 2:00 pm

    Speaker: Adrian F. Hernandez, MD, MHS Executive Director, Duke Clinical Research Institute Vice Dean, Duke University School of Medicine Title: Precision Health to Population Health: Opportunities and Challenges for Gene […]

  • Fri 9

    Grand Rounds August 9, 2024: Does Starting Buprenorphine Prevent Suicidal Behavior: What Trial Should We Emulate? (Gregory Simon, MD, MPH; Susan Shortreed PhD)

    August 9, 2024 @ 1:00 pm - 2:00 pm

    Speakers: Gregory Simon, MD, MPH Investigator Kaiser Permanente Washington Health Research Institute Susan Shortreed, PhD Investigator Kaiser Permanente Washington Health Research Institute Title: Does Starting Buprenorphine Prevent Suicidal Behavior: What Trial Should We Emulate? Date: Friday, August 9, 2024, 1:00-2:00 p.m. ET Please click the link below to join the webinar: https://duke.zoom.us/j/96235326296?pwd=n8babtt7UZQvzwTaCnWw2yWqgbJTyo.1 Passcode: 617743 One […]

  • Fri 16

    Grand Rounds August 16, 2024: Methodological Insights and Lessons Learned From Conducting a Pragmatic Randomized Trial on Surgical Face Masks (Runar Solberg, PhD)

    August 16, 2024 @ 1:00 pm - 2:00 pm

    Speaker: Runar Solberg, PhD Scientist Centre for Epidemic Interventions Research (CEIR) Norwegian Institute of Public Health Title: Methodological Insights and Lessons Learned From Conducting a Pragmatic Randomized Trial on Surgical Face Masks Date: Friday, August 16, 2024, 1:00-2:00 p.m. ET Please click the link below to join the webinar: https://duke.zoom.us/j/95476448869?pwd=eb4b3xpW0UBiLXRWGGF0mWPugB1Sn3.1 Passcode: 181864 One tap mobile […]

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