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Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • January 2025

  • Fri 24

    Grand Rounds January 24, 2025: The HEALing Communities Study – 10 Million People, 67 Communities: A Community-Based Cluster Randomized Trial to Reduce Opioid Overdose Deaths (Jeffrey H. Samet, MD, MA, MPH)

    January 24, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Jeffrey H. Samet, MD, MA, MPH John Noble Professor in General Internal Medicine & Professor of Public Health Boston University Chobanian and Avedisian School of Medicine and School of Public Health Boston Medical Center Title: The HEALing Communities Study – 10 Million People, 67 Communities: A Community-based Cluster Randomized Trial to Reduce Opioid Overdose […]

  • Fri 31

    Grand Rounds January 31, 2025: Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned (Richard L. Skolasky, ScD; Kevin H. McLaughlin, DPT)

    January 31, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Richard L. Skolasky, ScD Professor, Johns Hopkins School of Medicine Department of Orthopaedic Surgery Kevin H. McLaughlin, DPT Assistant Professor, Johns Hopkins School of Medicine Department of Physical Medicine and Rehabilitation Title: Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned Date: Friday, January 31, 2025, 1:00-2:00 p.m. ET […]

  • February 2025

  • Fri 7

    Grand Rounds February 7, 2025: Improving Symptom Control in Pediatric Cancer Patients With SSPedi and SPARK (Lillian Sung, MD, PhD)

    February 7, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Lillian Sung, MD, PhD Canada Research Chair in Pediatric Oncology Supportive Care Division of Haematology/Oncology Chief Clinical Data Scientist The Hospital for Sick Children Ontario, Canada Title: Improving Symptom […]

  • Fri 14

    Grand Rounds February 14, 2025: A Cluster Randomized, Stepped-Wedge Pragmatic Trial to Enhance Goals-of-Care Communication for Older Adults With Cancer (ACP-PEACE) (Angelo Volandes, MD, MPH; James A. Tulsky, MD)

    February 14, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Angelo Volandes, MD, MPH Vice Chair of Research, Department of Medicine Dartmouth Health Professor of Medicine, Geisel School of Medicine James A. Tulsky, MD Poorvu Jaffe Chair, Department of […]

  • Fri 21

    Grand Rounds February 21, 2025: Texting for Behavior Change: Lessons Learned Across 2 Interventions to Improve Chronic Care Management (Michael Ho, MD, PhD; Sheana Bull, PhD)

    February 21, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Michael Ho, MD, PhD Kaiser Permanente Colorado Sheana Bull, PhD University of Colorado School of Public Health Title: Texting for Behavior Change: Lessons Learned Across 2 Interventions to Improve […]

  • Fri 28

    Grand Rounds February 28, 2025: Behavioral Economic and Staffing Strategies To Increase Adoption of the ABCDEF Bundle in the Intensive Care Unit (BEST-ICU): Protocol, Challenges, and Major Updates (Michele C. Balas PhD, RN, CCRN-K, FCCM, FAAN; Eduard Vasilevskis, MD, MPH)

    February 28, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Michele C. Balas PhD, RN, CCRN-K, FCCM, FAAN Associate Dean of Research Dorothy Hodges Olson Distinguished Professor of Nursing University of Nebraska Medical Center College of Nursing Eduard Vasilevskis, […]

  • March 2025

  • Fri 7

    Grand Rounds March 7, 2025: A Trial of a “Kidney Action Team” for Hospitalized Patients with Acute Kidney Injury (F. Perry Wilson, MD MSCE)

    March 7, 2025 @ 1:00 pm - 2:00 pm

    Speaker: F. Perry Wilson, MD MSCE Associate Professor of Medicine and Public Health Director, Clinical and Translational Research Accelerator Yale University New Haven, CT Title: A Trial of a “Kidney […]

  • Fri 14

    Grand Rounds March 14, 2025: Spillover Due to Constraints on Care Delivery: A Potential Source of Bias in Pragmatic Clinical Trials (Sean Mann)

    March 14, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Sean Mann Senior Policy Analyst RAND Corporation Title: Spillover Due to Constraints on Care Delivery: A Potential Source of Bias in Pragmatic Clinical Trials Date: Friday, March 14, 2025, […]

  • Thu 20

    Essential Elements for Sharing a Data Package (NIH HEAL Initiative)

    March 20, 2025 @ 1:00 pm - 2:00 pm

    Essential Elements for Sharing a Data Package NIH HEAL Initiative Data Stewardship Group March 20, 2025; 1:00-2:00 pm ET The HEAL Data Stewardship Group is excited to announce the next […]

  • Fri 21

    Grand Rounds March 21, 2025: Generative Artificial Intelligence in Clinical Trials: A Driver of Efficiency and Democratization of Care (Alexander J. “AJ” Blood, MD, MSc)

    March 21, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Alexander J. “AJ” Blood, MD, MSc Associate Director, Accelerator for Clinical Transformation Research Group Instructor of Medicine at Harvard Medical School Cardiologist and Intensivist Brigham and Women's Hospital Title: […]

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