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Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

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  • November 2017

  • Fri 24

    Grand Rounds November 24: No Presentation (Thanksgiving Holiday Weekend)

    November 24, 2017 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    There will be no Grand Rounds presentation November 24, 2017 in observance of Thanksgiving Day.  We hope to see you next week. .  

  • December 2017

  • Fri 1

    Grand Rounds December 1: CIIC – Providing a Shared Repository of Detailed Clinical Models for all of Health and Healthcare (Stanley M. Huff, MD; W. Ed Hammond, PhD)

    Featured December 1, 2017 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speakers: Stanley M. Huff, MD Chief Medical Informatics Officer Intermountain Healthcare and Professor (Clinical) of Biomedical Informatics University of Utah W. Ed Hammond, PhD Duke Center for Health Informatics Clinical […]

  • Fri 8

    Grand Rounds December 8, 2017: Data and Safety Monitoring in Pragmatic Clinical Trials (Greg Simon, MD, MPH; Jeremy Sugarman, MD, MPH, MA; Susan Ellenberg, PhD)

    Featured December 8, 2017 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speakers: Greg Simon, MD, MPH Senior Investigator Kaiser Permanente Washington Health Research Institute Jeremy Sugarman, MD, MPH, MA Harvey M. Meyerhoff Professor of Bioethics and Medicine Johns Hopkins Berman Institute of Bioethics Susan S. Ellenberg, PhD Professor of Biostatistics Professor of Medical Ethics and Health Policy Department of Biostatistics, Epidemiology and Informatics, Perelman School of […]

  • Fri 15

    Grand Rounds December 15: Does Machine Learning Have a Place in a Learning Health System? (Michael Pencina, PhD)

    Featured December 15, 2017 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speaker: Michael Pencina, PhD Professor of Biostatistics and Bioinformatics, Duke University Director of Biostatistics Duke Clinical Research Institute Topic: Does machine learning have a place in a learning health system Date: Friday, December 15, 2017, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich […]

  • Fri 22

    Grand Rounds December 22: No Presentation (Holiday Weekend)

    December 22, 2017 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Grand Rounds December 22: No Presentation (Holiday Weekend) We hope to see you next week.

  • Fri 29

    Grand Rounds December 29: No Presentation (Holiday Weekend)

    December 29, 2017 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Grand Rounds December 29: No Presentation (Holiday Weekend) We hope to see you next week.

  • January 2018

  • Fri 5

    Grand Rounds January 5: IMPACT-AFib: An 80,000 person Randomized Trial Using the Sentinel Initiative Platform (Noelle M. Cocoros, DSc, MPH; Christopher B. Granger, MD, FACC, FAHA; Richard Platt MD, MS; Sean Pokorney, MD)

    Featured January 5, 2018 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speakers: Noelle M. Cocoros, DSc, MPH Epidemiologist, Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Christopher B. Granger, MD, FACC, FAHA Professor of Medicine, Duke University Director, Cardiac Care Unit Duke University Medical Center Richard Platt, MD, MS Professor and Chair, Department of Population Medicine Harvard Medical School and Harvard […]

  • Fri 12

    Grand Rounds January 12: Behavioral Economic Principles to Understand and Change Clinician Behavior (Jeffrey A. Linder, MD, MPH, FACP)

    Featured January 12, 2018 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speaker: Jeffrey A. Linder, MD, MPH, FACP Chief, Division of General Internal Medicine and Geriatrics Michael A. Gertz Professor of Medicine Northwestern University Feinberg School of Medicine Topic: Behavioral Economic Principles to Understand and Change Clinician Behavior Date: Friday, January 12, 2018, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players […]

  • Fri 19

    Grand Rounds January 19: The Healthcare Pivot: Technology and Transformation of Healthcare (Kevin A. Schulman, MD)

    Featured January 19, 2018 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speaker: Kevin A. Schulman, MD Professor of Medicine Associate Director, Duke Clinical Research Institute Visiting Scholar, Harvard Business School Topic: The Healthcare Pivot: Technology and Transformation of Healthcare Date: Friday, […]

  • Fri 26

    Grand Rounds January 26: The Lumbar Imaging with Reporting of Epidemiology (LIRE) Trial: Subsequent Cross-Sectional Imaging Through 90 Days- Preliminary Results (Jeffrey Jarvik, MD, MPH; Patrick Heagerty, PhD)

    Featured January 26, 2018 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speakers: Jeffrey (Jerry) G. Jarvik MD MPH Professor, Radiology, Neurological Surgery and Health Services Adjunct Professor, Pharmacy and Orthopedics & Sports Medicine Co-Director, Comparative Effectiveness, Cost and Outcomes Research Center Director, UW CLEAR Center for Musculoskeletal Disorders University of Washington Patrick J. Heagerty PhD Gilbert S. Omenn Endowed Chair in Biostatistics Professor and Chair, Department of Biostatistics University […]

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