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Living Textbook of
Pragmatic Clinical Trials

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Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • January 2018

  • Fri 5

    Grand Rounds January 5: IMPACT-AFib: An 80,000 person Randomized Trial Using the Sentinel Initiative Platform (Noelle M. Cocoros, DSc, MPH; Christopher B. Granger, MD, FACC, FAHA; Richard Platt MD, MS; Sean Pokorney, MD)

    Featured January 5, 2018 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speakers: Noelle M. Cocoros, DSc, MPH Epidemiologist, Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Christopher B. Granger, MD, FACC, FAHA Professor of Medicine, Duke University Director, Cardiac Care Unit Duke University Medical Center Richard Platt, MD, MS Professor and Chair, Department of Population Medicine Harvard Medical School and Harvard […]

  • Fri 12

    Grand Rounds January 12: Behavioral Economic Principles to Understand and Change Clinician Behavior (Jeffrey A. Linder, MD, MPH, FACP)

    Featured January 12, 2018 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speaker: Jeffrey A. Linder, MD, MPH, FACP Chief, Division of General Internal Medicine and Geriatrics Michael A. Gertz Professor of Medicine Northwestern University Feinberg School of Medicine Topic: Behavioral Economic Principles to Understand and Change Clinician Behavior Date: Friday, January 12, 2018, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players […]

  • Fri 19

    Grand Rounds January 19: The Healthcare Pivot: Technology and Transformation of Healthcare (Kevin A. Schulman, MD)

    Featured January 19, 2018 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speaker: Kevin A. Schulman, MD Professor of Medicine Associate Director, Duke Clinical Research Institute Visiting Scholar, Harvard Business School Topic: The Healthcare Pivot: Technology and Transformation of Healthcare Date: Friday, January 19, 2018, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files, […]

  • Fri 26

    Grand Rounds January 26: The Lumbar Imaging with Reporting of Epidemiology (LIRE) Trial: Subsequent Cross-Sectional Imaging Through 90 Days- Preliminary Results (Jeffrey Jarvik, MD, MPH; Patrick Heagerty, PhD)

    Featured January 26, 2018 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speakers: Jeffrey (Jerry) G. Jarvik MD MPH Professor, Radiology, Neurological Surgery and Health Services Adjunct Professor, Pharmacy and Orthopedics & Sports Medicine Co-Director, Comparative Effectiveness, Cost and Outcomes Research Center Director, UW CLEAR […]

  • February 2018

  • Fri 2

    Grand Rounds February 2: Early Progress on the All of Us Research Program (Joshua C. Denny, MD, MS, FACMI)

    Featured February 2, 2018 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speaker: Joshua C. Denny, MD, MS, FACMI Professor of Biomedical Informatics and Medicine Director, Center for Precision Medicine Vice President for Personalized Medicine Vanderbilt University Medical Center Topic: Early Progress […]

  • Fri 9

    Grand Rounds February 9: Linking Design to Analysis of Cluster Randomized Trials: Covariate Balancing Strategies (Fan Li, PhD)

    Featured February 9, 2018 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speaker: Fan Li, PhD Candidate in Biostatistics Department of Biostatistics and Bioinformatics Duke University Topic: Linking Design to Analysis of Cluster Randomized Trials: Covariate Balancing Strategies Date: Friday, February 9, 2018, […]

  • Fri 16

    Grand Rounds February 16: Considerations for the Return of Genomic Results (Heidi Rehm, PhD, FACMG; W. Andrew Faucett, MS, LGC)

    Featured February 16, 2018 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speakers: Heidi Rehm, PhD, FACMG Associate Professor of Pathology Brigham & Women's Hospital and Harvard Medical School W. Andrew (Andy) Faucett, MS, LGC Professor Director of Policy and Education Office […]

  • Fri 23

    Grand Rounds February 23: Direct Mail Programs Work… But Will Health Centers Implement Them? Findings from STOP CRC (Gloria D. Coronado, PhD; Beverly B. Green, MD, MPH)

    Featured February 23, 2018 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speakers: Gloria D. Coronado, PhD Senior Investigator Mitch Greenlick Endowed Scientist for Health Disparities Kaiser Permanente Center for Health Research Beverly B. Green, MD, MPH Associate Investigator Kaiser Permanente Washington […]

  • March 2018

  • Fri 2

    Grand Rounds March 2: Distributed Research Network Querying: A Status Report (Jeff Brown, PhD; Lesley H. Curtis, PhD; Richard Platt, MD, MSc)

    Featured March 2, 2018 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speakers: Jeff Brown, PhD Associate Professor, Department of Population Medicine Harvard Pilgrim Health Care Institute Lesley H. Curtis, PhD Professor of Medicine Director, Center for Population Health Sciences, Duke School […]

  • Tue 6

    March 6-7: Real-World Evidence Workshop Series- Workshop 2: Practical Approaches

    Featured March 6, 2018 @ 8:00 am - March 7, 2018 @ 12:30 pm

    The National Academies of Sciences, Engineering, and Medicine (National Academies) is convening the second workshop in a three-part series examining how real-world evidence development and uptake can enhance medical product […]

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