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Living Textbook of
Pragmatic Clinical Trials

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Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
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  • November 2018

  • Tue 6

    DCRI Research Forum: Dr. Jeffrey Jarvik on Lumbar Imaging with Reporting of Epidemiology (LIRE)

    November 6, 2018 @ 12:00 pm - 1:00 pm

    DCRI Research Forum  Dr. Jeffrey Jarvik on Lumbar Imaging with Reporting of Epidemiology (LIRE)  12:00 pm | Eastern Daylight Time (New York, GMT-04:00) | 1 hr. Meeting number (access code): 732 427 579 Meeting password: DCRI Join by phone: 1-650-479-3207 Call-in toll number (US/Canada) 1-855-244-8681 Call-in toll-free number (US/Canada) Toll-free calling restrictions Join from a video […]

  • Fri 9

    Grand Rounds November 9: Data Linkage Within, Across, and Beyond PCORnet

    November 9, 2018 @ 1:00 pm - 2:00 pm

    Speakers: Thomas W. Carton, PhD, MS Chief Data Officer, Louisiana Public Health Institute PI, REACHnet Keith Marsolo, PhD Instructor Department of Population Health Sciences Duke University School of Medicine Topic: Data Linkage Within, Across, and Beyond PCORnet Date: Friday, November 9, 2018, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed […]

  • Fri 16

    Grand Rounds November 16: Primary Palliative Care for Emergency Medicine (PRIM-ER)

    November 16, 2018 @ 1:00 pm - 2:00 pm

    Speakers: Corita R. Grudzen, MD, MSHS, FACEP Vice Chair for Research Associate Professor of Emergency Medicine and Population Health Ronald O. Perelman Department of Emergency Medicine NYU School of Medicine Topic: Primary Palliative Care for Emergency Medicine (PRIM-ER) Date: Friday, November 16, 2018, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players […]

  • Fri 23

    Grand Rounds November 23rd: No Presentation (Week of Thanksgiving)

    November 23, 2018 @ 1:00 pm - 2:00 pm

    Grand Rounds July 6th: No Presentation (In observance of the Thanksgiving holiday) We hope to see you next week.

  • Fri 30

    Grand Rounds November 30: Validating a Computable Phenotype: Should Results Change a Trial’s Pre-Specified Primary Outcome?

    November 30, 2018 @ 1:00 pm - 2:00 pm

    Speakers: Gregory E Simon MD MPH Senior Investigator, Kaiser Permanente Washington Health Research Institute Susan M. Shortreed, PhD Associate Investigator Biostatistics Unit, Kaiser Permanente Washington Health Research Institute Topic: Validating a Computable Phenotype: Should Results Change a Trial's Pre-Specified Primary Outcome? Date: Friday, November 30, 2018, 1:00-2:00 p.m. ET Meeting Info: To check whether you have […]

  • December 2018

  • Fri 7

    Grand Rounds December 7: Cluster randomized trials in health care delivery systems: lessons from STIC2IT

    December 7, 2018 @ 1:00 pm - 2:00 pm

    Speaker: Niteesh K. Choudhry, MD, PhD Professor, Harvard Medical School Executive Director, Center for Healthcare Delivery Sciences, Brigham and Women’s Hospital Topic: Cluster randomized trials in health care delivery systems: lessons from STIC2IT Date: Friday, December 7, 2018, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications […]

  • Fri 14

    Grand Rounds December 14: Guiding Good Choices for Health (GGC4H): Testing Feasibility and Effectiveness of Universal Parent-Focused Prevention in Three Healthcare Systems

    December 14, 2018 @ 1:00 pm - 2:00 pm

    Speakers: Richard F. Catalano, PhD, MPI GGC4H Co-Founder, Social Development Research Group Professor, School of Social Work University of Washington Margaret Kuklinski, PhD, MPI GGC4H Research Scientist Social Development Research Group School of Social Work University of Washington Stacy Sterling, DrPH, MSW, MPI GGC4H Research Scientist Drug and Alcohol Research Team Behavioral Health Research Initiative […]

  • Fri 21

    Grand Rounds December 21: No Presentation (Week before Christmas Holiday)

    December 21, 2018 @ 1:00 pm - 2:00 pm

    Grand Rounds December 21: No Presentation (In observance of Christmas holiday)  

  • Fri 28

    Grand Rounds December 28: No Presentation (New Year’s Holiday)

    December 28, 2018 @ 1:00 pm - 2:00 pm

    Grand Rounds December 28th: No Presentation (In observance of New Year's holiday) We hope to see you next week.

  • January 2019

  • Fri 4

    Grand Rounds January 4: TRANSFORMing Research for Patients With Heart Failure

    January 4, 2019 @ 1:00 pm - 2:00 pm

    Speakers: Robert J. Mentz, MD Associate Professor of Medicine Duke University School of Medicine Kevin J. Anstrom, PhD Professor of Biostatistics and Bioinformatics Director of Biostatistics, Duke Clinical Research Institute Duke University School of Medicine Eric Eisenstein, DBA Associate Professor in Medicine Duke University School of Medicine Stephen J. Greene, MD Fellow, Division of Cardiology […]

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