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Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • March 2019

  • Fri 29

    Grand Rounds March 29: ICD-Pieces: Lessons Learned in an Ongoing Trial

    March 29, 2019 @ 1:00 pm - 2:00 pm

    Speakers: Miguel A. Vazquez, MD Professor of Medicine Clinical Chief Nephrology Division UT Southwestern Medical Center George (Holt) Oliver, MD, PhD Vice President Clinical Informatics Parkland Center for Clinical Innovation […]

  • April 2019

  • Fri 5

    Grand Rounds April 5: The ENGAGES Pragmatic Trial and the Power of Negative Thinking

    April 5, 2019 @ 1:00 pm - 2:00 pm

    Speaker: Michael S. Avidan, MBBCh, FCA SA Dr. Seymour and Rose T. Brown Professor of Anesthesiology Chief, Division of Clinical and Translational Research Washington University in St. Louis, School of […]

  • Fri 12

    Grand Rounds April 12: Development of Harmonized Outcome Measures for Use in Research and Clinical Practice

    April 12, 2019 @ 1:00 pm - 2:00 pm

    Speakers: Richard Gliklich, MD CEO, OM1, Inc. Michelle B. Leavy, MPH Head, Healthcare Research & Policy OM1, Inc. Elise Berliner, PhD Director, Technology Assessment Program Center for Evidence and Practice […]

  • Fri 19

    Grand Rounds April 19: The Trauma Survivors Outcomes & Support (TSOS) Pragmatic Trial: Revisiting Effectiveness & Implementation Aims

    April 19, 2019 @ 1:00 pm - 2:00 pm

    Speaker: Doug Zatzick, MD Professor of Psychiatry Harborview Medical Center University of Washington School of Medicine Topic: The Trauma Survivors Outcomes & Support (TSOS) Pragmatic Trial : Revisiting Effectiveness & […]

  • Fri 26

    Grand Rounds April 26: The VERITAS Trial: Virtual Exercise Rehabilitation at the Intersection of Evidence, Implementation, and Policy

    April 26, 2019 @ 1:00 pm - 2:00 pm

    Speaker: Janet Prvu Bettger, ScD, FAHA Associate Professor Duke Department of Orthopaedic Surgery Duke Clinical Research Institute Topic: The VERITAS Trial: Virtual Exercise Rehabilitation at the Intersection of Evidence, Implementation, […]

  • May 2019

  • Thu 2

    NIH Workshop: Design & Analysis of Embedded Pragmatic Clinical Trials

    May 2, 2019 @ 8:00 am - 4:30 pm

    The NIH Health Care Systems Research Collaboratory is hosting a one-day workshop on the Design & Analysis of Embedded Pragmatic Clinical Trials (ePCTs) on May 2, 2019, in the Lister […]

  • Fri 3

    Grand Rounds May 3: Effects of Financial Bonus Sizes, Loss Aversion, and Increased Social Pressure on Physician Pay-for-Performance: A Randomized Trial and Cohort Study

    May 3, 2019 @ 1:00 pm - 2:00 pm

    Speaker: Amol S. Navathe, MD, PhD Assistant Professor of Medicine and Health Policy, University of Pennsylvania Topic: Effects of Financial Bonus Sizes, Loss Aversion, and Increased Social Pressure on Physician […]

  • Fri 10

    Grand Rounds May 10: Treating Data as an Asset: Data Entrepreneurship in the Service of Patients

    May 10, 2019 @ 1:00 pm - 2:00 pm

    Speaker: Eric D Perakslis MS PhD Rubenstein Fellow, Duke University Lecturer, Department of Biomedical Informatics Harvard Medical School Topic: Treating Data as an Asset: Data Entrepreneurship in the Service of […]

  • Fri 17

    Grand Rounds May 17: The VITamin D and OmegA-3 TriaL (VITAL): Design and Results of a Large Pragmatic Trial

    May 17, 2019 @ 1:00 pm - 2:00 pm

    Speaker: JoAnn E. Manson, MD, DrPH Chief, Division of Preventive Medicine, Brigham and Women's Hospital Professor of Medicine and the Michael and Lee Bell Professor of Women's Health, Harvard Medical […]

  • Fri 24

    Grand Rounds May 24: No Presentation (Memorial Day Holiday)

    May 24, 2019 @ 1:00 pm - 2:00 pm
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