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Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

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  • January 2019

  • Fri 11

    Grand Rounds January 11: Nudge: Text Messaging at Scale in Diverse Health Systems to Support Adherence to Cardiac Medication

    January 11, 2019 @ 1:00 pm - 2:00 pm

    Speakers: Sheana Bull, PhD, MPH Professor, Colorado School of Public Health Director, mHealth Impact Lab Michael Ho, MD, PhD Professor of Medicine, University of Colorado School of Medicine & Staff […]

  • Fri 18

    Grand Rounds January 18: Pragmatic Trials in End-stage Renal Disease (ESRD): HiLo

    January 18, 2019 @ 1:00 pm - 2:00 pm

    Speaker: Myles Wolf, MD, MMSc Charles Johnson, MD Professor of Medicine Chief, Duke Nephrology Duke University School of Medicine Topic: Pragmatic Trials in end-stage renal disease(ESRD): HiLo Date: Friday, January 18, […]

  • Fri 25

    Grand Rounds January 25: A Learning Health System Story: Perinatal Outcomes Associated with a Major Change in Gestational Diabetes Screening

    January 25, 2019 @ 1:00 pm - 2:00 pm

    Speakers: Sascha Dublin, MD PhD Senior Investigator Kaiser Permanente Washington Health Research Institute Gaia Pocobelli, PhD Research Associate Kaiser Permanente Washington Health Research Institute Topic: A Learning Health System Story: […]

  • February 2019

  • Fri 1

    Grand Rounds February 1: Promoting Effective Advance Care Planning Communication in the Elderly: The ACP-PEACE Trial

    February 1, 2019 @ 1:00 pm - 2:00 pm

    Speakers: James Tulsky, MD Chair, Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute Professor of Medicine, Harvard Medical School Chief, Division of Palliative Medicine, Brigham and Women’s Hospital […]

  • Fri 8

    Grand Rounds February 8: Paramedic Airway Management in Out-of-Hospital Cardiac Arrest – The Pragmatic Airway Resuscitation Trial (PART)

    February 8, 2019 @ 1:00 pm - 2:00 pm

    Speaker: Henry E. Wang, MD, MS Professor and Vice Chair for Research Department of Emergency Medicine University of Texas Health Science Center at Houston Topic: Paramedic Airway Management in Out-of-Hospital […]

  • Fri 15

    Grand Rounds February 15: Improving Qualification of Investigators: Recommendations from the Clinical Trials Transformation Initiative

    February 15, 2019 @ 1:00 pm - 2:00 pm

    Speakers: Christine M. Hildebrand, PA-C Physician Assistant Sub Investigator Clinical Operations Lead Amici Clinical Research Janette Panhuis Chief Operating Officer, Population Health Research Institute David Braley Research Institute Topic: Improving Qualification of Investigators: Recommendations from the Clinical Trials Transformation Initiative Date: Friday, February 15, 2019, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the […]

  • Fri 22

    Grand Rounds February 22: Going from a Learning Health System to Learning Health Units: Opportunities and Challenges

    February 22, 2019 @ 1:00 pm - 2:00 pm

    Speaker: Adrian F. Hernandez, MD MHS Vice Dean for Clinical Research Duke University School of Medicine Topic: Going from a Learning Health System to Learning Health Units: Opportunities and Challenges Date: Friday, February 22, 2019, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media […]

  • March 2019

  • Fri 1

    Grand Rounds March 1: Approaches to Patient Follow-Up for Clinical Trials: What’s the Right Choice for Your Study ?

    March 1, 2019 @ 1:00 pm - 2:00 pm

    Speaker: Keith Marsolo, PhD Instructor Department of Population Health Sciences Duke University School of Medicine Topic: Approaches to Patient Follow-Up for Clinical Trials: What’s the Right Choice for Your Study? Date: Friday, March 1, 2019, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media […]

  • Fri 8

    Grand Rounds March 8: Dietary Trials in Heart Failure: SODIUM-HF

    March 8, 2019 @ 1:00 pm - 2:00 pm

    Speaker: Justin A. Ezekowitz, MBBCh MSc Professor of Medicine, University of Alberta Co-director, Canadian VIGOUR Centre Topic: Dietary Trials in Heart Failure: SODIUM-HF Date: Friday, March 8, 2019, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files, go to https://dukemed.webex.com/dukemed/systemdiagnosis.php. To join the online […]

  • Fri 15

    Grand Rounds March 15: Leveraging RWE to Support Regulatory Decisions-An Update on Efforts to Inform Policy

    March 15, 2019 @ 1:00 pm - 2:00 pm

    Speaker: Gregory W. Daniel, PhD, MPH, RPh Deputy Center Director, Duke-Margolis Center for Health Policy Clinical Professor, Fuqua School of Business Duke University Topic: Leveraging RWE to Support Regulatory Decisions-An Update on Efforts to Inform Policy Date: Friday, March 15, 2019, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for […]

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