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Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

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  • February 2020

  • Fri 7

    Grand Rounds February 7: Using Nudges to Improve the Delivery of Health Care

    February 7, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Mitesh S. Patel, MD, MBA Ralph Muller Presidential Assistant Professor Perelman School of Medicine & Wharton School University of Pennsylvania Director, Penn Medicine Nudge Unit Topic: Using Nudges to […]

  • Fri 14

    Grand Rounds February 14: Do Our Current Research Models Meet the Needs of a Learning Health Care System?

    February 14, 2020 @ 1:00 pm - 2:00 pm

    Speaker: David Atkins, MD, MPH Director, Health Services Research and Development Office of Research and Development Department of Veterans Affairs Topic: Do Our Current Research Models Meet the Needs of a Learning Health Care System? Date: Friday, February 14, 2020, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for […]

  • Thu 20

    IMPACT Collaboratory Grand Rounds February 20: Modifications and waivers of informed consent in pragmatic clinical trials

    February 20, 2020 @ 12:00 pm - 1:00 pm

    Speakers:  Jason Karlawish, MD Professor of Medicine, Medical Ethics and Health Policy, and Neurology Co-Director, Penn Memory Center, University of Pennsylvania IMPACT Regulation and Ethics Core Leader Topic: Modifications and […]

  • Fri 21

    Grand Rounds February 21: Nudge Study Updates

    February 21, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Michael Ho, MD, PhD Professor of Medicine, University of Colorado School of Medicine Staff Cardiologist, Rocky Mountain Regional VA Medical Center Sheana Bull, PhD, MPH Professor, Colorado School of […]

  • Fri 28

    Living Textbook Grand Rounds Series February 28: Part 2-Preparing for the Unknown: Conducting Pragmatic Research in Real-World Contexts

    February 28, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Vincent Mor, PhD Florence Pirce Grant University Professor Department of Health Services Policy & Practice Brown University School of Public Health Leah Tuzzio, MPH Research Associate Kaiser Permanente Washington […]

  • March 2020

  • Fri 6

    Grand Rounds March 6: Creating a Learning Health System Through Randomization

    March 6, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Leora Horwitz, MD, MHS Associate Professor, Population Health and Medicine Director, Center for Healthcare Innovation and Delivery Science, NYU Langone Health Director, Division of Healthcare Delivery Science, Department of […]

  • Fri 13

    Grand Rounds March 13: Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus–Lessons Learned and Future Directions

    March 13, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Abhinav Sharma, MD, PhD Assistant Professor of Medicine McGill University Christopher B. Granger, MD, FAHA, FACC Professor of Medicine Director, Cardiac Intensive Care Unit Duke University Medical Center Topic: […]

  • Thu 19

    NIH Workshop March 19-20: Developing Meaningful Endpoints for Pain Clinical Trials

    March 19, 2020 @ 8:00 am - March 20, 2020 @ 5:00 pm

    Meeting Name: Developing Meaningful Endpoints for Pain Clinical Trials Meeting Dates: Thursday, March 19, 2020 to Friday, March 20, 2020 Location:  Bethesda Marriott Bethesda, Maryland United States Registration Date(s): Monday, […]

  • Fri 20

    Grand Rounds March 20: Clinical Trials in the Time of COVID-19

    March 20, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Susanna Naggie, MD Associate Dean for Clinical Research Initiatives and Regulatory Affairs Duke University School of Medicine Adrian F. Hernandez, MD, MHS Professor of Medicine Vice Dean for Clinical […]

  • Fri 27

    Living Textbook Grand Rounds Series March 27: Part 3-Tips for Putting Together a Successful PCT Grant Application

    March 27, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Wendy Weber, ND, PhD, MPH Branch Chief, Clinical Research Branch Division of Extramural Research, NCCIH Topic: Part 3-Tips for Putting Together a Successful PCT Grant Application Date: Friday, March […]

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