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Living Textbook of
Pragmatic Clinical Trials

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Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • February 2025

  • Fri 28

    Grand Rounds February 28, 2025: Behavioral Economic and Staffing Strategies To Increase Adoption of the ABCDEF Bundle in the Intensive Care Unit (BEST-ICU): Protocol, Challenges, and Major Updates (Michele C. Balas PhD, RN, CCRN-K, FCCM, FAAN; Eduard Vasilevskis, MD, MPH)

    February 28, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Michele C. Balas PhD, RN, CCRN-K, FCCM, FAAN Associate Dean of Research Dorothy Hodges Olson Distinguished Professor of Nursing University of Nebraska Medical Center College of Nursing Eduard Vasilevskis, […]

  • March 2025

  • Fri 7

    Grand Rounds March 7, 2025: A Trial of a “Kidney Action Team” for Hospitalized Patients with Acute Kidney Injury (F. Perry Wilson, MD MSCE)

    March 7, 2025 @ 1:00 pm - 2:00 pm

    Speaker: F. Perry Wilson, MD MSCE Associate Professor of Medicine and Public Health Director, Clinical and Translational Research Accelerator Yale University New Haven, CT Title: A Trial of a “Kidney […]

  • Fri 14

    Grand Rounds March 14, 2025: Spillover Due to Constraints on Care Delivery: A Potential Source of Bias in Pragmatic Clinical Trials (Sean Mann)

    March 14, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Sean Mann Senior Policy Analyst RAND Corporation Title: Spillover Due to Constraints on Care Delivery: A Potential Source of Bias in Pragmatic Clinical Trials Date: Friday, March 14, 2025, […]

  • Thu 20

    Essential Elements for Sharing a Data Package (NIH HEAL Initiative)

    March 20, 2025 @ 1:00 pm - 2:00 pm

    Essential Elements for Sharing a Data Package NIH HEAL Initiative Data Stewardship Group March 20, 2025; 1:00-2:00 pm ET The HEAL Data Stewardship Group is excited to announce the next […]

  • Fri 21

    Grand Rounds March 21, 2025: Generative Artificial Intelligence in Clinical Trials: A Driver of Efficiency and Democratization of Care (Alexander J. “AJ” Blood, MD, MSc)

    March 21, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Alexander J. “AJ” Blood, MD, MSc Associate Director, Accelerator for Clinical Transformation Research Group Instructor of Medicine at Harvard Medical School Cardiologist and Intensivist Brigham and Women's Hospital Title: […]

  • Fri 28

    Grand Rounds March 28, 2025: A Cross-Sectional Study of GPT-4–Based Plain Language Translation of Clinical Notes to Improve Patient Comprehension of Disease Course and Management (Matthew Engelhard, MD, PhD; Anivarya Kumar, BA)

    March 28, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Matthew Engelhard, MD, PhD Assistant Professor, Department of Biostatistics & Bioinformatics Duke University School of Medicine Anivarya Kumar, BA Fourth-Year Medical Student Duke University School of Medicine Title: A […]

  • April 2025

  • Fri 4

    Grand Rounds April 4, 2025: A Digital Health Behavior Intervention to Prevent Childhood Obesity: The Greenlight Plus Randomized Clinical Trial (Bill Heerman, MD, MPH)

    April 4, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Bill Heerman, MD, MPH Associate Professor of Internal Medicine and Pediatrics William K. Warren Foundation Chair in Medicine Chief, Division of Academic General Pediatrics Vanderbilt University Medical Center Title: […]

  • Fri 11

    Grand Rounds April 11, 2025: A Phase 2 Trial of Pridopidine in ALS, Studied as a Regimen With the Healey Platform Trial (Jeremy M. Shefner, MD, PhD)

    April 11, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Jeremy M. Shefner, MD, PhD Professor of Neurology Barrow Neurological Institute Title: A Phase 2 Trial of Pridopidine in ALS, Studied as a Regimen With the Healey Platform Trial Date: Friday, April 11, 2025, 1:00-2:00 p.m. ET Please click the link below to join the webinar: https://duke.zoom.us/j/91651086721?pwd=7DftSd42zfX3A3gWZQh3rtinj5SSGr.1 Passcode: 800685 One-Tap Mobile +16469313860,,91651086721#,,,,*800685# US +13017158592,,91651086721#,,,,*800685# […]

  • Fri 18

    Grand Rounds April 18, 2025: Colchicine and Spironolactone Post-MI: A Review of the Late-Breaking Results of the CLEAR OASIS 9 Trial (Sanjit S. Jolly, MD, MSc, FRCPC)

    April 18, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Sanjit S. Jolly, MD, MSc, FRCPC Interventional Cardiologist, Hamilton Health Sciences Stuart Connolly Chair in Cardiology Professor of Medicine, McMaster University Title: Colchicine and Spironolactone Post-MI: A Review of the Late-Breaking Results of the CLEAR OASIS 9 Trial Date: Friday, April 18, 2025, 1:00-2:00 p.m. ET Please click the link below to join the […]

  • Fri 25

    Grand Rounds April 25, 2025: Automated Response Technology Integrated into EMR and Physician-Patient Communication (Ming Tai-Seale, PhD, MPH)

    April 25, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Ming Tai-Seale, PhD, MPH Professor Departments of Family Medicine and Medicine (Bioinformatics) University of California San Diego School of Medicine Director of UC San Diego Learning Health Systems Science Center Title: Automated Response Technology Integrated into EMR and Physician-Patient Communication Date: Friday, April 25, 2025, 1:00-2:00 p.m. ET Please click the link below to […]

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