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NIH Collaboratory
Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

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  • April 2020

  • Fri 24

    Grand Rounds April 24: The RECOVERY Trial: A UK National Platform Trial of Potential Treatments for Patients Hospitalised with COVID-19

    April 24, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Martin Landray, PhD, FRCP Professor of Medicine & Epidemiology Nuffield Department of Population Health University of Oxford, UK Topic: The RECOVERY Trial: A UK National Platform Trial of Potential Treatments for Patients Hospitalised with COVID-19 Date: Friday, April 24, 2020, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed […]

  • May 2020

  • Fri 1

    Grand Rounds EHR Workshop Series May 1: Advances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials: Keynote-Can the COVID-19 Crisis Lead to Reformation of the Evidence Generation Ecosystem?

    May 1, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Robert Califf, MD, MACC Head of Strategy and Policy Verily Life Sciences and Google Health Topic: Advances at the Intersection of Digital Health, Electronic Health Records and Pragmatic Clinical Trials: Keynote-Can the COVID-19 Crisis Lead to Reformation of the Evidence Generation Ecosystem? Date: Friday, May 1, 2020, 1:00-2:00 p.m. ET Meeting Info: To check […]

  • Thu 7

    IMPACT Collaboratory Grand Rounds May 7: COVID-19 in Nursing Homes: Pragmatic Research Responses to the Crisis

    May 7, 2020 @ 12:00 pm - 1:00 pm

    Speakers:  David C. Grabowski, PhD Professor of Health Care Policy Department of Health Care Policy, Harvard Medical School Susan Mitchell, MD, MPH IMPACT Principal Investigator Professor of Medicine, Harvard Medical […]

  • Fri 8

    Grand Rounds EHR Workshop Series May 8: Advances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials: Real World Evidence: Contemporary Experience and Future Directions

    May 8, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Guest Moderator Patrick J. Heagerty PhD Professor, Department of Biostatistics, University of Washington Panel Jacqueline Corrigan-Curay, JD, MD Director of CDER’s Office of Medical Policy (OMP) U.S. Food and Drug Administration (FDA) Joshua C. Denny, MD, MS, FACMI Chief Executive Officer, All of Us Research Program, NIH Topic: Advances at the Intersection of Digital […]

  • Fri 15

    Grand Rounds May 15: Optimizing Learning While Doing: The REMAP-CAP Adaptive Platform Trial

    May 15, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Derek C. Angus, MD, MPH, FRCP Distinguished Professor and Mitchell P. Fink Endowed Chair Department of Critical Care Medicine University of Pittsburgh and UPMC Health System Topic: Optimizing Learning While Doing: The REMAP-CAP Adaptive Platform Trial Date: Friday, May 15, 2020, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players […]

  • Thu 21

    IMPACT Collaboratory Grand Rounds May 21: Stakeholder Engagement in ePCTs for People Living with Dementia

    May 21, 2020 @ 12:00 pm - 1:00 pm

    Speaker:  Ellen Tambor, MA Research Director, Center for Medical Technology Policy Executive Committee Member, IMPACT Stakeholder Engagement Team Topic: Stakeholder Engagement in ePCTs for People Living with Dementia Date: Thursday, […]

  • Fri 22

    Grand Rounds May 22: No Presentation (Memorial Day Holiday)

    May 22, 2020 @ 1:00 pm - 2:00 pm
  • Fri 29

    Grand Rounds EHR Workshop Series May 29: Advances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials: Experiences from the Collaboratory PCTs

    May 29, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Guest Moderator Wendy Weber, ND, PhD, MPH Branch Chief, Clinical Research in Complementary and Integrative Health Division of Extramural Research National Center for Complementary and Integrative Health, NIH Panel […]

  • June 2020

  • Fri 5

    Grand Rounds June 5: PCORnet COVID-19 Common Data Model Design and Results

    June 5, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Thomas W. Carton, PhD, MS Chief Data Officer Louisiana Public Health Institute Keith Marsolo, PhD Associate Professor Department of Population Health Sciences Duke Clinical Research Institute Duke University School […]

  • Fri 12

    Grand Rounds June 12: A Cluster Randomized Pragmatic Trial of an Advance Care Planning Video Intervention in Long-Stay Nursing Home Residents: Main Findings from the PROVEN Trial

    June 12, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Susan L. Mitchell MD, MPH Senior Scientist Hebrew SeniorLife Hinda and Arthur Marcus Institute for Aging Research Professor of Medicine Harvard Medical School Topic: A Cluster Randomized Pragmatic Trial […]

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