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Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • August 2020

  • Fri 14

    Grand Rounds August 14: Learning While Sprinting: A One-Year Retrospective from the NOHARM Pragmatic Trial

    August 14, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Jon Tilburt, MD Professor of Medicine and Biomedical Ethics Mayo Clinic Andrea Cheville, MD Professor of Physical Medicine and Rehabilitation Mayo Clinic Topic: Learning While Sprinting: A One-Year Retrospective […]

  • Fri 21

    Grand Rounds August 21: Adaptive Platform Trials: Scalable from Breast Cancer to COVID

    August 21, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Laura Esserman, MD, MBA Director, UCSF Carol Franc Buck Breast Care Center Alfred A. de Lorimier Endowed Chair in General Surgery Professor of Surgery and Radiology, UCSF Topic: Adaptive […]

  • Fri 28

    Grand Rounds August 28: Designing, Conducting, Monitoring, and Analyzing Data from Pragmatic Clinical Trials: Proceedings from a Multi-Stakeholder Think Tank Meeting

    August 28, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Lesley Curtis, PhD Chair and Professor, Department of Population Health Sciences Duke University School of Medicine Trevor Lentz, PT, PhD, MHA Assistant Professor in Orthopaedic Surgery Duke Clinical Research […]

  • September 2020

  • Fri 4

    Grand Rounds September 4: No Presentation (Labor Day Holiday)

    September 4, 2020 @ 1:00 pm - 2:00 pm
  • Fri 11

    Grand Rounds September 11: Launching CONNECTS: Collaborating Network of Networks for Evaluating COVID-19 and Therapeutic Strategies

    September 11, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Gordon R. Bernard, MD CONNECTS ACC Science Unit P Professor of Medicine Executive Vice President for Research Senior Associate Dean for Clinical Science Vanderbilt University Medical Center Sonia Thomas, […]

  • Wed 16

    September 16-17: PCORI 2020 Virtual Annual Meeting – Accelerating Impact on Care and Patient-Centered Outcomes

    September 16, 2020 - September 17, 2020

    Registration is now open for PCORI's sixth Annual Meeting, Accelerating Impact on Care and Patient-Centered Outcomes, being held virtually September 16-17. Join this FREE event celebrating PCORI's 10-year anniversary and […]

  • Thu 17

    September 17, 2020: NIA IMPACT Grand Rounds: Not All Approaches to Data Are Created Equal: Data-related Challenges for Pragmatic Trials Involving Patients Living With Dementia

    September 17, 2020 @ 12:00 pm - 1:00 pm

    Presenters: David Dorr, MD, MS Professor & Vice-Chair of Medical Informatics and Clinical Epidemiology Professor of Medicine, Division of General Internal Medicine and Geriatrics Chief Research Information Officer, Biomedical Informatics […]

  • Fri 18

    Grand Rounds September 18: The Trauma Survivors Outcomes and Support (TSOS) Pragmatic Clinical Trial: Effectiveness and Implementation Process Assessment Results

    September 18, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Douglas Zatzick, MD Professor of Psychiatry and Behavioral Sciences Harborview Medical Center, University of Washington School of Medicine Topic: The Trauma Survivors Outcomes and Support (TSOS) Pragmatic Clinical Trial: […]

  • Fri 25

    Grand Rounds September 25: Accelerating the Nation’s COVID-19 Testing Capacity: An Update from the NIH’s RADx Program

    September 25, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Rick Bright, PhD Senior Advisor to the NIH Director Rachael Fleurence, PhD Special Assistant to the NIH Director for COVID-19 Diagnostics Topic: Accelerating the Nation’s COVID-19 Testing Capacity: An […]

  • October 2020

  • Fri 2

    Grand Rounds October 2: Driving Toward Health Impact: Our Journey and Path Forward

    October 2, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Nakela L. Cook, MD, MPH Executive Director PCORI Topic: Driving Toward Health Impact: Our Journey and Path Forward Date: Friday, October 2, 2020, 1:00-2:00 p.m. ET Meeting Info: To […]

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