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Living Textbook of
Pragmatic Clinical Trials

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Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • October 2020

  • Fri 9

    Grand Rounds October 9: Pragmatic Trial of Higher vs. Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis (HiLo)

    October 9, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Myles Wolf, MD, MMSc Division of Nephrology, Department of Medicine Duke Clinical Research Institute Duke University School of Medicine Topic: Pragmatic Trial of Higher vs. Lower Serum Phosphate Targets […]

  • Thu 15

    October 15, 2020: NIA IMPACT Collaboratory Grand Rounds: The AHRQ and Lancet Reports on Dementia Interventions: Interpretation and Implications for Embedded Pragmatic Trials

    October 15, 2020 @ 12:00 pm - 1:00 pm

    Presenters: Joe Gaugler, PhD Robert L. Kane Endowed Chair in Long-Term Care and Aging Professor, University of Minnesota Associate Core Leader, IMPACT Implementation Core Eric Larson, MD, MPH Vice President, […]

  • Fri 16

    Grand Rounds October 16: Back to School, It’s More Than Just a Trip to Target This Year: The ABC Science Collaborative

    October 16, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Danny Benjamin, MD, PhD Kiser-Arena Distinguished Professor of Pediatrics, Duke University Chair, Pediatric Trials Network Deputy Director, Duke Clinical Research Institute Topic: Back to School, It’s More Than Just […]

  • Fri 23

    Grand Rounds October 23: Outpatient Clinical Decision Support – An Evidence-Based Implementation Framework

    October 23, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Patrick O'Connor, MD, MA, MPH Senior Clinical Investigator HealthPartners Institute JoAnn Sperl-Hillen, MD Senior Clinical Investigator HealthPartners Institute Topic: Outpatient Clinical Decision Support - An Evidence Based Implementation Framework […]

  • Tue 27

    October 27-30: Simplifying Informed Consent – OHRP Virtual Workshop at the NIH Office of Extramural Research Fall Regional Seminar

    October 27, 2020 @ 8:00 am - October 30, 2020 @ 5:00 pm

    The NIH Office of Extramural Research (OER) will host its semi-annual regional seminar virtually this fall from October 27-30. Registration is required, and the event is free. Mark your calendars […]

  • Fri 30

    Grand Rounds October 30: Lessons from Virtual Trials in Time of a Pandemic: Minnesota Hydroxychloroquine Experience

    October 30, 2020 @ 1:00 pm - 2:00 pm

    Speaker: David R. Boulware MD, MPH Professor of Medicine Infectious Disease & International Medicine Department of Medicine University of Minnesota Topic: Lessons from Virtual Trials in Time of a Pandemic: […]

  • November 2020

  • Fri 6

    Grand Rounds November 6: Appendectomy vs Antibiotics for Appendicitis-Early Results from the CODA trial

    November 6, 2020 @ 1:00 pm - 2:00 pm

    Speaker: David R. Flum, MD, MPH Professor, Surgery, Health Services, and Pharmacy Associate Chair for Research, Department of Surgery University of Washington Topic: Appendectomy vs Antibiotics for Appendicitis-Early Results from the […]

  • Fri 13

    Grand Rounds November 13: Pragmatic and Explanatory Attitudes to RCTs: Using the PRECIS-2 Tool to Describe the Design of the MyTEMP Trial

    November 13, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Ahmed Al-Jaishi, PhD (candidate) Health Research Methodology McMaster University Amit Garg, MD, PhD Professor, Department of Medicine Epidemiology & Biostatistics Western University, London, Canada Senior Core Scientist, Site Director, […]

  • Thu 19

    NIA IMPACT Collaboratory Grand Rounds: Implementation Outcomes: Their Role in Treatment Success

    November 19, 2020 @ 12:00 pm - 1:00 pm

    Presenter: Enola Proctor, PhD Shanti K. Khinduka Distinguished Professor Emeritus Brown School Washington University, St. Louis Zoom Details: Please click the link below to join the webinar: https://hebrewseniorlife.zoom.us/j/97344810673 Webinar ID: […]

  • Fri 20

    Grand Rounds November 20: Drug Development in Kidney Disease: Proceedings from a Multi-Stakeholder Panel

    November 20, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Daniel Edmonston, MD Medical Instructor Duke University School of Medicine Topic: Drug Development in Kidney Disease: Proceedings from a Multi-Stakeholder Panel Date: Friday, November 20, 2020, 1:00-2:00 p.m. ET […]

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