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Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

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  • April 2021

  • Fri 30

    Grand Rounds April 30: ACTIV-6: A Direct-to-Participant Platform Trial of Repurposed Drugs for COVID-19 in Non-hospitalized Patients

    April 30, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Susanna Naggie, MD, MHS Associate Professor of Medicine Duke Clinical Research Institute Elizabeth Shenkman, PhD Chair, Department of Health Outcomes and Biomedical Informatics Co-Director, Clinical and Translational Science Institute (CTSI) University of Florida Topic: ACTIV-6: A Direct-to-Participant Platform Trial of Repurposed Drugs for COVID-19 in Non-hospitalized Patients Date: Friday, April 30, 2021, 1:00-2:00 p.m. […]

  • May 2021

  • Fri 7

    Grand Rounds May 7: Online Recruitment in the Era of COVID-19: Pitfalls and Progress

    May 7, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Megan L. Ranney, MD, MPH, FACEP Director, Brown-Lifespan Center for Digital Health Warren Alpert Endowed Associate Professor of Emergency Medicine, Brown University Associate Dean of Strategy and Innovation, School […]

  • Fri 14

    Grand Rounds Diversity Workshop Series May 14: Keynote Session: Diverse Representation Among Clinical Trial Participants: Why It Is Important and How Can We Improve

    May 14, 2021 @ 1:00 pm - 2:00 pm

    Guest Moderator: Kanecia Zimmerman, MD Associate Professor of Pediatrics Duke University School of Medicine Speaker: Clyde W. Yancy, MD, MSc, MACC, FAHA, MACP, FHFSA Vice Dean, Diversity and Inclusion Northwestern […]

  • Thu 20

    NIA IMPACT Collaboratory Grand Rounds May 20: Pilot and Feasibility Studies for Pragmatic Cluster Randomised Trials

    May 20, 2021 @ 12:00 pm - 1:00 pm

    Presenter: Claire Chan, MSc Statistician Institute of Population Health Sciences Queen Mary University of London Zoom Details: Please click the link below to join the webinar: https://hebrewseniorlife.zoom.us/j/97344810673 Webinar ID: 973 […]

  • Fri 21

    Grand Rounds May 21: The PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation in Trial Design and Delivery

    May 21, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Chris Butler, MD Nuffield Department of  Primary Care Health Sciences University of Oxford Ben Saville, PhD Berry Consultants Topic: The PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation […]

  • Fri 28

    Grand Rounds May 28: No Presentation (Memorial Day Holiday)

    May 28, 2021 @ 1:00 pm - 2:00 pm
  • June 2021

  • Fri 4

    Grand Rounds Diversity Workshop Series June 4: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Planning for Diversity – Stakeholder Engagement and Site Selection to Maximize Diversity

    June 4, 2021 @ 1:00 pm - 2:00 pm

    Guest Moderator: Wendy Weber, ND, PhD, MPH Chief, Clinical Research in Complementary and Integrative Health Branch Division of Extramural Research National Center for Complementary and Integrative Health (NCCIH) National Institutes […]

  • Fri 11

    Grand Rounds June 11: The TSOS Effectiveness-Implementation Hybrid Study: Health Care System Level Theoretical Considerations & Pragmatic Trial Results

    June 11, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Douglas Zatzick, MD Professor, Department of Psychiatry and Behavioral Sciences University of Washington School of Medicine Topic: The TSOS Effectiveness-Implementation Hybrid Study: Health Care System Level Theoretical Considerations & […]

  • Thu 17

    NIA IMPACT Collaboratory Grand Rounds June 17: Promises and Pitfalls of Existing Data in Nursing Homes

    June 17, 2021 @ 12:00 pm - 1:00 pm

    Presenters: Debra Saliba, MD, MPH Anna and Harry Borun Endowed Chair in Geriatrics and Gerontology at UCLA Director, UCLA/JH Borun Center for Gerontological Research Associate Director for Education, VA Los […]

  • Fri 18

    Grand Rounds June 18: The MITIGATE Study: Insights from a Decentralized, Virtual, Electronic Health Record-Based Pragmatic Clinical Trial

    June 18, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Andrew P. Ambrosy, MD Research Scientist Cardiovascular and Metabolic Conditions Research Solution Through Technology and Advanced Analytic Research (STAR) Group Kaiser Permanente Northern California Division of Research Alan S. […]

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