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Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

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  • March 2021

  • Fri 19

    Grand Rounds March 19: HERO–Learning Together about Vaccines for SARS-CoV-2

    March 19, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Emily O’Brien, PhD, FAHA Associate Professor Duke Clinical Research Institute Duke University School of Medicine Robert M. Califf, MD, MACC Head of Clinical Policy and Strategy Verily Life Sciences and Google Health Topic: HERO–Learning Together about Vaccines for SARS-CoV-2 Date: Friday, March 19, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you have […]

  • Fri 26

    Grand Rounds March 26: The Path to Preventive Genomics

    March 26, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Robert C. Green, MD, MPH Professor of Medicine (Genetics), Harvard Medical School Director, Genomes2People Research Program and Preventive Genomics Clinic Mass General Brigham, Ariadne Labs, Broad Institute Topic: The Path to Preventive Genomics Date: Friday, March 26, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal […]

  • April 2021

  • Fri 2

    Grand Rounds April 2: Lessons from COVID-19: The First Year of the REMAP-CAP Global Adaptive Platform Trial

    April 2, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Derek C. Angus, MD, MPH, FRCP Chief Healthcare Innovation Officer, UPMC Associate Vice Chancellor for Healthcare Innovation, University of Pittsburgh Schools of the Health Sciences Distinguished Professor and Mitchell P. Fink Endowed Chair Department of Critical Care Medicine, University of Pittsburgh and UPMC Topic: Lessons from COVID-19: The First Year of the REMAP-CAP Global […]

  • Fri 9

    Grand Rounds April 9: Taking Research to the Participant: Experiences with TREAT NOW, a No-Touch COVID-19 Trial

    April 9, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Adit Ginde, MD, MPH Professor and Vice Chair for Research, Department of Emergency Medicine Director of Clinical Research, Department of Anesthesiology Director, Colorado CTSI Trial Innovation Network Hub University of Colorado School of Medicine Topic: Taking Research to the Participant: Experiences with TREAT NOW, a No-Touch COVID-19 Trial Date: Friday, April 9, 2021, 1:00-2:00 […]

  • Thu 15

    NIA IMPACT Collaboratory Grand Rounds April 15: Inclusion, Diversity, and Equity in Pragmatic Clinical Trials

    April 15, 2021 @ 12:00 pm - 1:00 pm

    Presenters: Consuelo H. Wilkins, MD, MSCI Vice President for Health Equity Vanderbilt University Medical Center Professor of Medicine Vanderbilt School of Medicine Zoom Details: Please click the link below to join the webinar: https://hebrewseniorlife.zoom.us/j/97344810673 Webinar ID: 973 4481 0673 International numbers available: https://hebrewseniorlife.zoom.us/u/ac4bYFtynq

  • Fri 16

    Grand Rounds April 16: Minnesota EHR Consortium COVID-19 Project: A Statewide Collaboration to Inform Vaccine Equity

    April 16, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Paul E. Drawz, MD, MHS, MS Associate Professor Division of Renal Disease and Hypertension University of Minnesota Tyler N.A. Winkelman, MD, MSc Co-Director, Health, Homelessness, and Criminal Justice Lab Associate Director, Virtual Data Warehouse Hennepin Healthcare Research Institute Topic: Minnesota EHR Consortium COVID-19 Project: A Statewide Collaboration to Inform Vaccine Equity Date: Friday, April […]

  • Fri 23

    Grand Rounds April 23: COVID Clinical Trials: The Intermountain Healthcare Experience

    April 23, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Samuel M. Brown, MD, MS Associate Professor and Director of Pulmonary/Critical Care Research Intermountain Healthcare Associate Professor, University of Utah Topic: COVID Clinical Trials: The Intermountain Healthcare Experience Date: Friday, April 23, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media […]

  • Fri 30

    Grand Rounds April 30: ACTIV-6: A Direct-to-Participant Platform Trial of Repurposed Drugs for COVID-19 in Non-hospitalized Patients

    April 30, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Susanna Naggie, MD, MHS Associate Professor of Medicine Duke Clinical Research Institute Elizabeth Shenkman, PhD Chair, Department of Health Outcomes and Biomedical Informatics Co-Director, Clinical and Translational Science Institute (CTSI) University of Florida Topic: ACTIV-6: A Direct-to-Participant Platform Trial of Repurposed Drugs for COVID-19 in Non-hospitalized Patients Date: Friday, April 30, 2021, 1:00-2:00 p.m. […]

  • May 2021

  • Fri 7

    Grand Rounds May 7: Online Recruitment in the Era of COVID-19: Pitfalls and Progress

    May 7, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Megan L. Ranney, MD, MPH, FACEP Director, Brown-Lifespan Center for Digital Health Warren Alpert Endowed Associate Professor of Emergency Medicine, Brown University Associate Dean of Strategy and Innovation, School […]

  • Fri 14

    Grand Rounds Diversity Workshop Series May 14: Keynote Session: Diverse Representation Among Clinical Trial Participants: Why It Is Important and How Can We Improve

    May 14, 2021 @ 1:00 pm - 2:00 pm

    Guest Moderator: Kanecia Zimmerman, MD Associate Professor of Pediatrics Duke University School of Medicine Speaker: Clyde W. Yancy, MD, MSc, MACC, FAHA, MACP, FHFSA Vice Dean, Diversity and Inclusion Northwestern […]

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