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Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

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  • October 2021

  • Fri 15

    Grand Rounds October 15: The Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in Bangladesh

    October 15, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Jason Abaluck, PhD Professor of Economics Yale School of Management Topic: The Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in Bangladesh Date: Friday, October 15, 2021, 1:00-2:00 […]

  • Fri 22

    Grand Rounds October 22: The STAMP Trial: Increasing Engagement in Advance Care Planning and Lessons Learned from Partnering with Community Ambulatory Practices

    October 22, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Terri R. Fried, MD Section Chief, Geriatrics Professor of Medicine Yale School of Medicine Attending Physician VA Connecticut Healthcare System Topic: The STAMP Trial: Increasing Engagement in Advance Care […]

  • Fri 29

    Grand Rounds October 29: Embedding Pragmatic Trials into Emergency and Critical Care

    October 29, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Matthew W. Semler, MD, MSc Assistant Professor Vanderbilt University Medical Center Jonathan D. Casey, MD, MSc Assistant Professor Vanderbilt University Medical Center Topic: Embedding Pragmatic Trials into Emergency and […]

  • November 2021

  • Fri 5

    Grand Rounds November 5: Benefits of Stroke Treatment Delivered Using a Mobile Stroke Unit Compared to Standard Management by Emergency Medical Services: The BEST-MSU Study

    November 5, 2021 @ 1:00 pm - 2:00 pm

    Speaker: James C Grotta, MD Director Stroke Research and Mobile Stroke Unit Memorial Hermann Hospital-Texas Medical Center Houston, Texas Topic: Benefits of Stroke Treatment Delivered Using a Mobile Stroke Unit […]

  • Fri 12

    Grand Rounds November 12: Using Financial Incentives to Increase COVID-19 Vaccine Uptake

    November 12, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Charlene Wong, MD MSHP Associate Professor of Pediatrics and Public Policy Duke University School of Medicine Chief Health Policy Officer for COVID-19 North Carolina Department of Health and Human […]

  • Fri 19

    Grand Rounds November 19: Exploring Approaches in Using Digital and Mobile Health in Patient-oriented Research: Pearls and Pitfalls

    November 19, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Anish K. Agarwal MD, MPH MS Assistant Professor of Emergency Medicine Clinical Innovation Manager, Penn Medicine Center for Health Care Innovation University of Pennsylvania, Perelman School of Medicine Topic: […]

  • Fri 26

    Grand Rounds November 26: No Presentation (Thanksgiving Holiday)

    November 26, 2021 @ 1:00 pm - 2:00 pm
  • December 2021

  • Fri 3

    Grand Rounds December 3: Primary Care-Based Behavioral Treatment for Long Term Opioid Users with Chronic Pain: Primary Results and Lessons Learned from the PPACT Pragmatic Trial

    December 3, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Lynn DeBar, PhD MPH Senior Scientist Kaiser Permanente Washington Health Research Institute Seattle, WA Topic: Primary Care-Based Behavioral Treatment for Long Term Opioid Users with Chronic Pain: Primary Results […]

  • Fri 10

    Grand Round December 10: Decentralized Trials: Naughty or Nice?

    December 10, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Adrian F. Hernandez, MD, MHS Executive Director, Duke Clinical Research Institute Vice Dean, Duke University School of Medicine Topic: Decentralized Trials: Naughty or Nice? Date: Friday, December 10, 2021, […]

  • Fri 17

    Grand Rounds December 17: Cyberthreat, Cybersecurity and Cyber Compliance in Clinical Research and Healthcare: One Size Fits None

    December 17, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Eric Perakslis PhD Chief Science & Digital Officer Duke Clinical Research Institute Professor Department of Population Health Sciences Chief Research Technology Strategist Duke University School of Medicine Topic: Cyberthreat, […]

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