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Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • December 2021

  • Fri 24

    Grand Rounds December 24: No Presentation (Holiday Break)

    December 24, 2021 @ 1:00 pm - 2:00 pm
  • Fri 31

    Grand Rounds December 31: No Presentation (Holiday Break)

    December 31, 2021 @ 1:00 pm - 2:00 pm
  • January 2022

  • Fri 7

    Grand Rounds January 7: D-PRESCRIBE-AD: A Pragmatic Trial to Educate and Sensitize Caregivers and Healthcare Providers to Reduce Inappropriate Prescription Burden in Persons Living with Dementia

    January 7, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Jerry H. Gurwitz, MD Chief, Division of Geriatric Medicine University of Massachusetts Medical School and UMass Memorial Medical Center Executive Director, Meyers Health Care Institute A joint endeavor of […]

  • Fri 14

    Grand Rounds January 14: Searching for a Unicorn: Understanding Stakeholder Perspectives When Selecting Outcomes for Outpatient Trials

    January 14, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Christopher Lindsell, PhD Professor of Biostatistics and Biomedical Informatics Director, Vanderbilt Institute for Clinical and Translational Research (VICTR) Methods Program Codirector, Vanderbilt Health Data Science (HEADS) Center Topic: Searching […]

  • Fri 21

    Grand Rounds January 21: Primary Palliative Care for Emergency Medicine

    January 21, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Corita R. Grudzen, MD, MSHS, FACEP Professor, Emergency Medicine and Population Health Associate Dean, Clinical Sciences Deputy Director, Clinical and Translational Science Institute Vice Chair for Research, Emergency Medicine […]

  • Fri 28

    Grand Rounds January 28: EMBED Trial Results: Pragmatic Trial of User-Centered Clinical Decision Support to Implement Emergency Department-Initiated Buprenorphine for Opioid Use Disorder

    January 28, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Edward R Melnick, MD, MHS Associate Professor of Emergency Medicine, Yale School of Medicine Associate Professor of Biostatistics (Health Informatics), Yale School of Public Health Program Director, Yale-VA Clinical […]

  • February 2022

  • Fri 4

    Grand Rounds February 4: SPIRRIT-HFpEF: Opportunities and Challenges in a Large Registry-Based Randomized Clinical Trial

    February 4, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Adam DeVore, MD, MHS Associate Professor of Medicine Duke University Medical Center Duke Clinical Research Institute Lars Lund, MD, PhD Professor of Cardiology Karolinska Institutet Karolinska University Hospital Topic: […]

  • Fri 11

    Grand Rounds February 11: Great Power and Great Responsibility: Machine Learning in Clinical Research(E. Hope Weissler, MD, MHS; Erich Huang, MD, PhD)

    February 11, 2022 @ 1:00 pm - 2:00 pm

    Speakers: E. Hope Weissler, MD, MHS Resident, Vascular and Endovascular Surgery Duke University School of Medicine Erich Huang, MD, PhD Chief Science and Innovation Officer, Onduo Topic: Great Power and […]

  • Fri 18

    Grand Rounds February 18: Building a Resource: The Process of Developing a Trans-stakeholder Framework to Enable Pediatric Drug Development(Perdita Taylor-Zapata, MD)

    February 18, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Perdita Taylor-Zapata, MD Best Pharmaceuticals for Children Act (BPCA) Program Lead and NICHD Program Officer Obstetric and Pediatric Pharmacology and Therapeutics Branch National Institute of Child Health and Human […]

  • Fri 25

    Grand Rounds February 25: The Next Generation of Patient-Centered Trials – No Site Visits, Home-delivery of Meds and Patient-reported Outcomes – The CHIEF-HF Trial(John Spertus MD MPH FACC FAHA)

    February 25, 2022 @ 1:00 pm - 2:00 pm

    Speaker: John Spertus, MD MPH FACC FAHA Daniel Lauer/Missouri Endowed Chair and Professor University of Missouri – Kansas City Clinical Director of Outcomes Research Saint Luke’s Mid America Heart Institute […]

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