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Living Textbook of
Pragmatic Clinical Trials

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Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

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  • November 2021

  • Fri 19

    Grand Rounds November 19: Exploring Approaches in Using Digital and Mobile Health in Patient-oriented Research: Pearls and Pitfalls

    November 19, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Anish K. Agarwal MD, MPH MS Assistant Professor of Emergency Medicine Clinical Innovation Manager, Penn Medicine Center for Health Care Innovation University of Pennsylvania, Perelman School of Medicine Topic: […]

  • Fri 26

    Grand Rounds November 26: No Presentation (Thanksgiving Holiday)

    November 26, 2021 @ 1:00 pm - 2:00 pm
  • December 2021

  • Fri 3

    Grand Rounds December 3: Primary Care-Based Behavioral Treatment for Long Term Opioid Users with Chronic Pain: Primary Results and Lessons Learned from the PPACT Pragmatic Trial

    December 3, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Lynn DeBar, PhD MPH Senior Scientist Kaiser Permanente Washington Health Research Institute Seattle, WA Topic: Primary Care-Based Behavioral Treatment for Long Term Opioid Users with Chronic Pain: Primary Results […]

  • Fri 10

    Grand Round December 10: Decentralized Trials: Naughty or Nice?

    December 10, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Adrian F. Hernandez, MD, MHS Executive Director, Duke Clinical Research Institute Vice Dean, Duke University School of Medicine Topic: Decentralized Trials: Naughty or Nice? Date: Friday, December 10, 2021, […]

  • Fri 17

    Grand Rounds December 17: Cyberthreat, Cybersecurity and Cyber Compliance in Clinical Research and Healthcare: One Size Fits None

    December 17, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Eric Perakslis PhD Chief Science & Digital Officer Duke Clinical Research Institute Professor Department of Population Health Sciences Chief Research Technology Strategist Duke University School of Medicine Topic: Cyberthreat, […]

  • Fri 24

    Grand Rounds December 24: No Presentation (Holiday Break)

    December 24, 2021 @ 1:00 pm - 2:00 pm
  • Fri 31

    Grand Rounds December 31: No Presentation (Holiday Break)

    December 31, 2021 @ 1:00 pm - 2:00 pm
  • January 2022

  • Fri 7

    Grand Rounds January 7: D-PRESCRIBE-AD: A Pragmatic Trial to Educate and Sensitize Caregivers and Healthcare Providers to Reduce Inappropriate Prescription Burden in Persons Living with Dementia

    January 7, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Jerry H. Gurwitz, MD Chief, Division of Geriatric Medicine University of Massachusetts Medical School and UMass Memorial Medical Center Executive Director, Meyers Health Care Institute A joint endeavor of […]

  • Fri 14

    Grand Rounds January 14: Searching for a Unicorn: Understanding Stakeholder Perspectives When Selecting Outcomes for Outpatient Trials

    January 14, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Christopher Lindsell, PhD Professor of Biostatistics and Biomedical Informatics Director, Vanderbilt Institute for Clinical and Translational Research (VICTR) Methods Program Codirector, Vanderbilt Health Data Science (HEADS) Center Topic: Searching […]

  • Fri 21

    Grand Rounds January 21: Primary Palliative Care for Emergency Medicine

    January 21, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Corita R. Grudzen, MD, MSHS, FACEP Professor, Emergency Medicine and Population Health Associate Dean, Clinical Sciences Deputy Director, Clinical and Translational Science Institute Vice Chair for Research, Emergency Medicine […]

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