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Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • July 2021

  • Fri 9

    Grand Rounds July 9: COVID-19 Vaccine Efficacy Studies: Challenges and Successes

    July 9, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Hana El Sahly, MD Professor of Molecular Virology and Microbiology Baylor College of Medicine Houston, TX Topic: COVID-19 Vaccine Efficacy Studies: Challenges and Successes Date: Friday, July 9, 2021, […]

  • Fri 16

    Grand Rounds Diversity Workshop Series July 16: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Maximizing Diversity in PCTs – What Can We Learn From Implementation Trials?

    July 16, 2021 @ 1:00 pm - 2:00 pm

    Guest Moderator: David Chambers, DPhil Deputy Director for Implementation Science Office of the Director in the Division of Cancer Control and Population Sciences (DCCPS) National Cancer Institute (NCI) National Institutes […]

  • Fri 23

    Grand Rounds July 23: Long Term COVID Patient Engagement: Best Practices Informed By Patients’ Experiences Seeking Medical Care

    July 23, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Diana Berrent, JD Survivor Corps, Founder Natalie Lambert, PhD Associate Research Professor Indiana University School of Medicine Nick Guthe Survivor Corps Member and Advisor   Topic: Long Term COVID […]

  • Fri 30

    Grand Rounds Diversity Workshop Series July 30: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Diversity in the PCT Ecosystem – How Do We Develop a Pipeline of Diverse Investigators and Leaders in PCTs?

    July 30, 2021 @ 1:00 pm - 2:00 pm

    Guest Moderator: Lesley Curtis, PhD Professor in Population Health Sciences Department of Population Health Sciences Duke University School of Medicine Panel: Marie A. Bernard, MD Acting NIH Chief Officer for […]

  • August 2021

  • Fri 6

    Grand Rounds August 6: The TOGETHER Early Treatment of COVID Trial: Building Platform Trial Infrastructure for Infectious Diseases

    August 6, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Edward Mills, PhD, FRCP Professor Department of Health Research Methods, Evidence & Impact McMaster University, Canada Topic: The TOGETHER Early Treatment of COVID Trial: Building Platform Trial Infrastructure for […]

  • Fri 13

    Grand Rounds August 13: Got anything for this cough? Outpatient Treatment Trials in the Time of COVID

    August 13, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Davey Smith, MD Protocol Co-Chair ACTIV-2 Professor of Medicine, UC San Diego Topic: Got anything for this cough? Outpatient Treatment Trials in the Time of COVID Date: Friday, August […]

  • Fri 20

    Grand Rounds August 20: Fluvoxamine for Early Treatment of COVID-19: The STOP COVID Clinical Trials

    August 20, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Eric Lenze, MD Wallace and Lucille K. Renard Professor of Psychiatry Washington University School of Medicine, St. Louis Topic: Fluvoxamine for Early Treatment of COVID-19: The STOP COVID Clinical […]

  • Fri 27

    Grand Rounds August 27: Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock: the DOREMI trial

    August 27, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Benjamin Hibbert, MD, PhD Clinician Scientist and Interventional Cardiologist University of Ottawa Heart Institute Topic: Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock: the DOREMI trial […]

  • September 2021

  • Fri 3

    Grand Rounds September 3: No Presentation (Labor Day Holiday)

    September 3, 2021 @ 1:00 pm - 2:00 pm
  • Fri 10

    Grand Rounds September 10: Effect of Salt Substitution on Cardiovascular Events and Death

    September 10, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Bruce Neal, MB ChB, PhD, FRCP, FAHA, FAHMS Executive Director, George Institute Australia Professor of Medicine, UNSW Sydney Honorary Professor, Sydney Medical School, University of Sydney Professor of Clinical […]

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