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Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • August 2025

  • Fri 22

    Grand Rounds August 22, 2025: The PCORnet Playbook: Avoiding the Fumble in Pragmatic Trials (Emily O’Brien, PhD, FAHA)

    August 22, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Emily O’Brien, PhD, FAHA Associate Professor Duke Clinical Research Institute Duke University School of Medicine Department of Population Health Sciences Title: The PCORnet Playbook: Avoiding the Fumble in Pragmatic Trials Date: Friday, August 22, 2025, 1:00-2:00 p.m. ET Please click the link below to join the webinar: https://duke.zoom.us/j/97298221531?pwd=KntWBf1FAbj75gXb1aDhYx0UILnI76.1 Passcode: 440270 One-Tap Mobile +16469313860,,97298221531#,,,,*440270# +13017158592,,97298221531#,,,,*440270# […]

  • September 2025

  • Fri 5

    Grand Rounds September 5, 2025: The Non-Learning Health System (Robert Califf, MD)

    September 5, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Robert Califf, MD Instructor in Medicine Duke University Medical Center Former Commissioner of Food and Drugs Title: The Non-Learning Health System Date: Friday, September 5, 2025, 1:00-2:00 p.m. ET Please click the link below to join the webinar: https://duke.zoom.us/j/97297984183?pwd=avfqcJIzyHNOmKVZXeqhWUfjgbqAgB.1 Passcode: 107078 One-Tap Mobile +16469313860,,97297984183#,,,,*107078# +13017158592,,97297984183#,,,,*107078# Audio Only Option +1 646 931 3860 +1 301 […]

  • Fri 12

    Grand Rounds September 12, 2025: Initial Outcomes of the Optimizing Pain Treatment in Medical Settings Using Mindfulness (OPTIMUM) Pragmatic Trial (Natalia E. Morone, MD, MS; Carol M. Greco, PhD; Kim Faurot, PhD)

    September 12, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Natalia E. Morone, MD, MS Boston Medical Center/Boston University Carol M. Greco, PhD University of Pittsburgh Kim Faurot, PhD University of North Carolina at Chapel Hill Title: Initial Outcomes of the Optimizing Pain Treatment in Medical Settings Using Mindfulness (OPTIMUM) Pragmatic Trial Date: Friday, September 12, 2025, 1:00-2:00 p.m. ET Please click the link […]

  • Fri 19

    Grand Rounds September 19, 2025: Hurdles for the Delivery of Trials: Insights From the Randomized Embedded Multifactorial Adaptive Platform Trial on Community-Acquired Pneumonia (REMAP-CAP) in Europe (Denise van Hout, MD, PhD)

    September 19, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Denise van Hout, MD, PhD Postdoctoral Researcher Julius Center for Health Sciences and Primary Care University Medical Center Utrecht, the Netherlands Title: Hurdles for the Delivery of Trials: Insights From the Randomized Embedded Multifactorial Adaptive Platform Trial on Community-Acquired Pneumonia (REMAP-CAP) in Europe Date: Friday, September 19, 2025, 1:00-2:00 p.m. ET Please click the […]

  • Fri 26

    Grand Rounds September 26, 2025: Significance in ePCTs: P Values vs Decision-Maker Perspectives (Gregory E. Simon, MD, MPH; Susan Huang, MD, MPH; Elizabeth Turner, PhD)

    September 26, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Gregory E. Simon, MD, MPH Kaiser Permanente Washington Health Research Institute Susan Huang, MD, MPH University of California Irvine Elizabeth Turner, PhD Duke University Title: Significance in Pragmatic Clinical Trials: P Values vs Decision-Maker Perspectives Date: Friday, September 26, 2025, 1:00-2:00 p.m. ET Please click the link below to join the webinar: https://duke.zoom.us/j/97064984108?pwd=H27M8zd7Pij4F1DzSvirq8og6aF5fN.1 Passcode: […]

  • October 2025

  • Fri 3

    Grand Rounds October 3, 2025: Multi-Domain Rehabilitation for Older Patients With Myocardial Infarction: The PIpELINe Trial (Elisabetta Tonet, MD)

    October 3, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Elisabetta Tonet, MD Cardiology Consultant Cardiology Unit Azienda Ospedaliero–Universitaria di Ferrara, Italy Title: Multi-Domain Rehabilitation for Older Patients With Myocardial Infarction: The PIpELINe Trial Date: Friday, October 3, 2025, 1:00-2:00 p.m. ET Please click the link below to join the webinar: https://duke.zoom.us/j/91312366543?pwd=UGEgWdNNNaRO5cMtbNVcLfBkQpr0OZ.1 Passcode: 326792 One-Tap Mobile +16469313860,,91312366543#,,,,*326792# +13017158592,,91312366543#,,,,*326792# Audio Only Option +1 646 931 […]

  • Fri 10

    Grand Rounds October 10, 2025: Engaging Rural Communities in Pragmatic Clinical Trials: Leveraging the CARE for Health Initiative Hubs to Enhance Enrollment for BeatPain (Julie M. Fritz, PhD, PT, FAPTA; Sebastian Tong, MD, MPH)

    October 10, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Julie M. Fritz, PhD, PT, FAPTA Distinguished Professor Department of Physical Therapy & Athletic Training University of Utah Sebastian Tong, MD, MPH Associate Professor University of Washington Title: Engaging Rural Communities in Pragmatic Clinical Trials: Leveraging the CARE for Health Initiative Hubs to Enhance Enrollment for BeatPain Date: Friday, October 10, 2025, 1:00-2:00 p.m. […]

  • Fri 17

    Grand Rounds October 17, 2025: Making Effective Use of Data Infrastructure in PCORnet® (Charles Bailey, MD, PhD; Keith Marsolo, PhD)

    October 17, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Charles Bailey, MD, PhD Department of Pediatrics Perelman School of Medicine University of Pennsylvania Biomedical and Health Informatics Children’s Hospital of Philadelphia Keith Marsolo, PhD Associate Professor Department of Population Health Sciences Duke Clinical Research Institute Duke University School of Medicine Title: Making Effective Use of Data Infrastructure in PCORnet® Date: Friday, October 17, […]

  • Fri 24

    Grand Rounds October 24, 2025: Studying Neglected Diseases: Insights from the PARACHUTE-HF Trial (Renato Lopes MD, PhD)

    October 24, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Renato Lopes MD, PhD Professor of Medicine, Division of Cardiology Duke University Medical Center Duke Clinical Research Institute Title: Studying Neglected Diseases: Insights from the PARACHUTE-HF Trial Date: Friday, October 24, 2025, 1:00-2:00 p.m. ET Please click the link below to join the webinar: https://duke.zoom.us/j/95426638742?pwd=Tz702ByfCbfa3EDhUaajOpbsshq6xp.1 Passcode: 044731 One-Tap Mobile +16468769923,,95426638742#,,,,*044731# +16469313860,,95426638742#,,,,*044731# Audio Only Option […]

  • Fri 31

    Grand Rounds October 31, 2025: The LHS Shared Commitments — All Treats, No Tricks (Peter Margolis, MD, PhD; Sean C. Dowdy, MD, FACS, FACOG; Sarah Greene, MPH)

    October 31, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Peter Margolis, MD, PhD Adjunct Professor of Pediatrics Stanford University School of Medicine Emeritus Professor of Pediatrics University of Cincinnati School of Medicine Former Co-Director of the James M. […]

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