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Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • August 2022

  • Fri 5

    Grand Rounds August 5: Economic Evaluation of Platform Trial Designs (Jay JH Park, PhD, MSc)

    August 5, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Jay JH Park, PhD, MSc Assistant Professor Department of Health Research Methods, Evidence and Impact Faculty of Health Sciences McMaster University Topic: Economic Evaluation of Platform Trial Designs Date: […]

  • Fri 12

    Grand Rounds August 12: Equitably Including Diverse Participants in Pragmatic Clinical Trials (Consuelo H. Wilkins, MD, MSCI)

    August 12, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Consuelo H. Wilkins, MD, MSCI Senior Vice President and Senior Associate Dean for Health Equity and Inclusive Excellence Professor of Medicine Vanderbilt University Medical Center   Topic: Equitably Including […]

  • Fri 19

    Grand Rounds August 19: Inclusion and Diversity in Clinical Trials: Actionable Steps to Drive Lasting Change (Gerald Bloomfield, MD, MPH; Michelle Kelsey, MD)

    August 19, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Gerald Bloomfield, MD, MPH Associate Professor with Tenure, Medicine Associate Professor, Global Health Duke University Michelle Kelsey, MD Assistant Professor of Medicine Duke University School of Medicine   Topic: […]

  • Fri 26

    Grand Rounds August 26: The Diuretic Comparison Project: A Large Pragmatic Clinical Trial (Areef Ishani, MD, MS)

    August 26, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Areef Ishani, MD MS Director, Primary Care and Specialty Medicine Service Line Minneapolis VA Health Care System Professor of Medicine University of Minnesota Topic: The Diuretic Comparison Project: A Large Pragmatic Clinical Trial Date: Friday, August 26, 2022, 1:00-2:00 p.m. ET   Meeting Info: To check whether you have the appropriate players installed for […]

  • September 2022

  • Fri 9

    Grand Rounds Ethics and Regulatory Series September 9: Building an Academic Learning Health System: Why Is It So Hard? (Steven Joffe, MD, MPH)

    September 9, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Steven Joffe, MD, MPH Art and Ilene Penn Professor and Chair Department of Medical Ethics & Health Policy University of Pennsylvania Perelman School of Medicine Topic: Keynote: Building an Academic Learning Health System: Why Is It So Hard? Date: Friday, September 9, 2022, 1:00-2:00 p.m. ET   Meeting Info: To check whether you have […]

  • Fri 16

    Grand Rounds September 16: Using Nationwide Registries to Conduct Pragmatic Randomized Trials: The DANFLU Program (Tor Biering-Sørensen, MD, PhD, MPH)

    September 16, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Tor Biering-Sørensen, MD, PhD, MPH Professor in Translational Cardiology and Pragmatic Randomized Trials Head of Center for Translational Cardiology and Pragmatic Randomized Trials Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen Head of Cardiovascular Non-Invasive Imaging Research Laboratory Department of Cardiology Copenhagen University Hospital - Herlev and Gentofte Topic: Using […]

  • Fri 23

    Grand Rounds September 23: Effect Of An Intensive Nurse Home Visiting Program On Adverse Birth Outcomes In A Medicaid-Eligible Population (Margaret McConnell, PhD)

    September 23, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Margaret McConnell, PhD Associate Professor Harvard T.H. Chan School of Public Health Topic: Effect Of An Intensive Nurse Home Visiting Program On Adverse Birth Outcomes In A Medicaid-Eligible Population Date: Friday, September 23, 2022, 1:00-2:00 p.m. ET   Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) […]

  • Fri 30

    Grand Rounds September 30: CTTI’s Digital Health Trials Hub: Multi-Stakeholder Resources to Conduct Effective Digital Health Trials (Marianne Chase; Jörg Goldhahn, MD)

    September 30, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Marianne Chase Senior Director Clinical Trial Operations Neurological Clinical Research Institute Massachusetts General Hospital Jörg Goldhahn, MD Medical Director Director of Institute for Translational Medicine ETH Zurich Topic: CTTI’s Digital Health Trials Hub: Multi-Stakeholder Resources to Conduct Effective Digital Health Trials Date: Friday, September 30, 2022, 1:00-2:00 p.m. ET   Meeting Info: To check […]

  • October 2022

  • Fri 7

    Grand Rounds October 7: Impact Of Handovers Of Anesthesia Care On Morbidity And Mortality (Melanie Meersch-Dini, MD)

    October 7, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Melanie Meersch-Dini, MD Professor Department of Anesthesiology, Intensive Care and Pain Medicine University Hospital Münster, Germany Topic: Impact Of Handovers Of Anesthesia Care On Morbidity And Mortality Date: Friday, October 7, 2022, 1:00-2:00 p.m. ET   Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media […]

  • Fri 14

    Grand Rounds Ethics and Regulatory Series October 14: Responding (or Not) to Signals of Potential Clinical Significance in Pragmatic Clinical Trials (Joseph Ali, JD; Leslie J. Crofford, MD; Tanya Matthews, PhD)

    October 14, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Joseph Ali, JD Assistant Professor, Dept. of International Health Johns Hopkins Bloomberg School of Public Health Core Faculty & Associate Director for Global Programs Johns Hopkins Berman Institute of Bioethics Tanya Matthews, PhD HRPP Director Kaiser Permanente Washington Leslie J. Crofford, MD Wilson Family Chair in Medicine Professor of Medicine and Pathology, Microbiology & […]

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