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Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • February 2022

  • Fri 4

    Grand Rounds February 4: SPIRRIT-HFpEF: Opportunities and Challenges in a Large Registry-Based Randomized Clinical Trial

    February 4, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Adam DeVore, MD, MHS Associate Professor of Medicine Duke University Medical Center Duke Clinical Research Institute Lars Lund, MD, PhD Professor of Cardiology Karolinska Institutet Karolinska University Hospital Topic: […]

  • Fri 11

    Grand Rounds February 11: Great Power and Great Responsibility: Machine Learning in Clinical Research(E. Hope Weissler, MD, MHS; Erich Huang, MD, PhD)

    February 11, 2022 @ 1:00 pm - 2:00 pm

    Speakers: E. Hope Weissler, MD, MHS Resident, Vascular and Endovascular Surgery Duke University School of Medicine Erich Huang, MD, PhD Chief Science and Innovation Officer, Onduo Topic: Great Power and […]

  • Fri 18

    Grand Rounds February 18: Building a Resource: The Process of Developing a Trans-stakeholder Framework to Enable Pediatric Drug Development(Perdita Taylor-Zapata, MD)

    February 18, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Perdita Taylor-Zapata, MD Best Pharmaceuticals for Children Act (BPCA) Program Lead and NICHD Program Officer Obstetric and Pediatric Pharmacology and Therapeutics Branch National Institute of Child Health and Human […]

  • Fri 25

    Grand Rounds February 25: The Next Generation of Patient-Centered Trials – No Site Visits, Home-delivery of Meds and Patient-reported Outcomes – The CHIEF-HF Trial(John Spertus MD MPH FACC FAHA)

    February 25, 2022 @ 1:00 pm - 2:00 pm

    Speaker: John Spertus, MD MPH FACC FAHA Daniel Lauer/Missouri Endowed Chair and Professor University of Missouri – Kansas City Clinical Director of Outcomes Research Saint Luke’s Mid America Heart Institute […]

  • March 2022

  • Fri 4

    Grand Rounds March 4: ACP COVID: A Trial to Evaluate an Advance Care Planning Video and Communication Skills Training Intervention for Older Adults During an Evolving Pandemic (Angelo E. Volandes, MD, MPH; James A. Tulsky, MD; Sophia N. Zupanc, BA)

    March 4, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Angelo E. Volandes, MD, MPH Associate Professor, Harvard Medical School and Massachusetts General Hospital James A. Tulsky, MD Chair, Department of Psychosocial Oncology and Palliative Care Dana-Farber Cancer Institute […]

  • Fri 11

    Grand Rounds March 11: Understanding a Patient’s Daily Experience Through Mobile Devices and Wearables: Lessons Learned From the 8,000 Patient MIPACT Study and Implementation in a National Pragmatic Trial (Sachin Kheterpal, MD, MBA; Jessica Golbus, MD; Nicole Pescatore, MPH)

    March 11, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Sachin Kheterpal, MD, MBA Professor of Anesthesiology Associate Dean for Research IT PI for MIPACT and Co-PI for THRIVE University of Michigan Jessica Golbus, MD Clinical Instructor, Cardiovascular Medicine […]

  • Fri 18

    Grand Rounds March 18: Better Data on Ivermectin Is Finally Here: Results from the TOGETHER Trial (Edward Mills, PhD, FRCP; Craig Rayner, PharmD)

    March 18, 2022 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speakers: Edward Mills PhD, FRCP Professor, McMaster University Craig R Rayner FRCP Edin PharmD MBA Certara Distinguished Scientist Adjunct Associate Professor, Monash University   Topic: Better Data on Ivermectin Is Finally Here: Results from the TOGETHER Trial Date: Friday, March 18, 2022, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players […]

  • Fri 25

    Grand Rounds March 25: A Telehealth-Delivered Pragmatic Trial of Mindfulness for Persons with Chronic Low Back Pain (Natalia Morone, MD, MS)

    March 25, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Natalia E. Morone, MD, MS Associate Professor of Medicine Boston University/Boston Medical Center   Topic: A Telehealth-Delivered Pragmatic Trial of Mindfulness for Persons with Chronic Low Back Pain Date: Friday, March 25, 2022, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media […]

  • April 2022

  • Fri 1

    Grand Rounds April 1: ICD-Pieces: Improving Care for CKD, Diabetes and Hypertension in Health Systems (Miguel A. Vazquez, MD; George (Holt) Oliver, MD, PhD)

    April 1, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Miguel A. Vazquez, MD Professor of Medicine University of Texas Southwestern Medical Center Dallas, TX George (Holt) Oliver, MD, PhD Vice President Clinical Informatics Parkland Center for Clinical Innovation Dallas, TX   Topic: ICD-Pieces: Improving Care for CKD, Diabetes and Hypertension in Health Systems Date: Friday, April 1, 2022, 1:00-2:00 p.m. ET Meeting Info: […]

  • Fri 8

    Grand Rounds April 8: COVID-19 Surveillance in PCORnet: Year 2 Update (Jason Block, MD, MPH; Thomas W. Carton, PhD, MS)

    April 8, 2022 @ 1:00 pm - 2:00 pm
    https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6

    Speaker: Jason Block, MD, MPH Associate Professor Harvard Pilgrim Health Care Institute Harvard Medical School Thomas W. Carton, PhD, MS Chief Data Officer Louisiana Public Health Institute Topic: COVID-19 Surveillance in PCORnet: Year 2 Update Date: Friday, April 8, 2022, 1:00-2:00 pm ET Meeting Info: To check whether you have the appropriate players installed for […]

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