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Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • May 2023

  • Fri 12

    Grand Rounds May 12, 2023: Design and Pragmatic Trial of COACH: A Patient Portal/EHR Information System for Home Blood Pressure Monitoring in Hypertension (Richelle J. Koopman, MD, MS)

    May 12, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Richelle J. Koopman, MD, MS Professor and Vice Chair for Research and Faculty Affairs Jack M. and Winifred S. Colwill Endowed Professor Department of Family and Community Medicine University of Missouri Topic: Design and Pragmatic Trial of COACH: A Patient Portal/EHR Information System for Home Blood Pressure Monitoring in Hypertension Date: Friday, May 12, […]

  • Fri 19

    Grand Rounds May 19, 2023: Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis After a Fracture (Robert O’Toole, MD)

    May 19, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Robert O’Toole, MD Chief of Orthopaedics, R Adams Cowley Shock Trauma Center Head, Division of Orthopaedic Trauma Department of Orthopaedics Director, Clinical Research, Department of Orthopaedics University of Maryland School of Medicine Topic: Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis After a Fracture Date: Friday, May 19, 2023, 1:00-2:00 p.m. ET To join the online […]

  • June 2023

  • Fri 2

    Grand Rounds June 2, 2023: PROACT Xa and the Wizard of Oz: Behind the Curtain of a Pragmatic Decentralized Clinical Trial (John Alexander, MD, MHS)

    June 2, 2023 @ 1:00 pm - 2:00 pm

    Speaker: John Alexander, MD, MHS Professor of Medicine/Cardiology DCRI/Duke University Topic: PROACT Xa and the Wizard of Oz: Behind the Curtain of a Pragmatic Decentralized Clinical Trial Date: Friday, June 2, 2023, 1:00-2:00 p.m. ET To join the online meeting: Click the Zoom Meeting link below: https://duke.zoom.us/j/96153659804?pwd=VmNJVDE5VmtFbUFHY0lZeTM1K0Y5QT09 Meeting ID: 961 5365 9804 Passcode: 12345 One […]

  • Fri 9

    Grand Rounds June 9, 2023: Emulating Randomized Clinical Trials with Non-randomized Real-world Evidence Studies: Results From The RCT DUPLICATE Initiative (Shirley V. Wang, PhD)

    June 9, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Shirley V. Wang, PhD Associate Professor Division of Pharmacoepidemiology and Pharmacoeconomics Brigham and Women’s Hospital Harvard Medical School Topic: Emulating Randomized Clinical Trials with Non-randomized Real-world Evidence Studies: Results From The RCT DUPLICATE Initiative Date: Friday, June 9, 2023, 1:00-2:00 p.m. ET To join the online meeting: Click the Zoom Meeting link below: https://duke.zoom.us/j/96153659804?pwd=VmNJVDE5VmtFbUFHY0lZeTM1K0Y5QT09 […]

  • Fri 16

    Grand Rounds June 16, 2023: BeatPain Utah Pragmatic Clinical Trial: Partnering with Community Health Centers Within a Socio-Technical Framework (Julie Fritz, PT, PhD, FAPTA; Guilherme Del Fiol, MD, PhD)

    June 16, 2023 @ 1:00 pm - 2:00 pm

    Speakers: Julie Fritz, PT, PhD, FAPTA Distinguished Professor, Department of Physical Therapy & Athletic Training Associate Dean for Research, College of Health University of Utah Guilherme Del Fiol, MD, PhD Professor, Biomedical Informatics University of Utah Topic: BeatPain Utah Pragmatic Clinical Trial: Partnering with Community Health Centers Within a Socio-Technical Framework Date: Friday, June 16, […]

  • Tue 20

    Virtual Workshop: Getting the Right Evidence to Decision-Makers Faster

    June 20, 2023 @ 11:00 am - June 21, 2023 @ 2:00 pm

    The NIH Pragmatic Trials Collaboratory will host a virtual workshop June 20-21, 2023, to explore the critical cycle of evidence generation to decision by health system leaders to implement the findings of pragmatic clinical trials (PCTs) conducted within health care systems. The workshop, Getting the Right Evidence to Decision-Makers Faster, will kick off on Tuesday, June 20, at 11:00 […]

  • Fri 23

    Grand Rounds June 23, 2023: Improving Delivery of Care for Chronic Kidney Disease, Diabetes in Hypertension (Miguel A. Vazquez, MD; George Oliver, MD, PhD)

    June 23, 2023 @ 1:00 pm - 2:00 pm

    Speakers: Miguel A. Vazquez, MD Professor of Medicine University of Texas Southwestern Medical Center Dallas, TX George Oliver, MD, PhD Vice President Clinical Informatics Parkland Center for Clinical Innovation Dallas, TX Topic: Improving Delivery of Care for Chronic Kidney Disease, Diabetes in Hypertension Date: Friday, June 23, 2023, 1:00-2:00 p.m. ET To join the online meeting: […]

  • Fri 30

    Grand Rounds June 30, 2023: Decentralized Trials – From Guidance to Reality & What’s Left (Adrian Hernandez, MD, MHS; Pamela Tenaerts, MD, MPH; Craig Lipset, MPH)

    June 30, 2023 @ 1:00 pm - 2:00 pm

    Speakers: Adrian Hernandez, MD, MHS Director, Duke Clinical Research Institute Pamela Tenaerts, MD, MPH Chief Scientific Officer, Medable Craig Lipset, MPH Co-Chair, Decentralized Trials & Research Alliance Topic: Decentralized Trials - From Guidance to Reality & What’s Left Date: Friday, June 30, 2023, 1:00-2:00 p.m. ET To join the online meeting: Click the Zoom Meeting […]

  • July 2023

  • Fri 7

    Grand Rounds July 7, 2023: Implementing Virtual Strategies Across an Integrated Healthcare System: The IMPLEMENT-HF Study (Ankeet S. Bhatt, MD, MBA, ScM)

    July 7, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Ankeet S. Bhatt, MD, MBA, ScM Associate Physician, Kaiser Permanente San Francisco Medical Center Research Scientist, Kaiser Permanente Northern California Division of Research Topic: Implementing Virtual Strategies Across an Integrated Healthcare System: The IMPLEMENT-HF Study Date: Friday, July 7, 2023, 1:00-2:00 p.m. ET To join the online meeting: Click the Zoom Meeting link below: […]

  • Fri 14

    Grand Rounds July 14, 2023: Lessons From the COORDINATE-Diabetes Trial (Christopher B. Granger, MD; Neha J. Pagidipati, MD, MPH)

    July 14, 2023 @ 1:00 pm - 2:00 pm

    Speakers: Christopher B. Granger, MD Donald F. Fortin, M.D. Distinguished Professor of Medicine Professor of Nursing Duke University Neha J. Pagidipati, MD MPH Associate Professor of Medicine, Duke University School of Medicine Topic: Lessons from the COORDINATE-Diabetes Trial Date: Friday, July 14, 2023, 1:00-2:00 p.m. ET To join the online meeting: Click the Zoom Meeting […]

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