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Living Textbook of
Pragmatic Clinical Trials

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Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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Today
  • April 2023

  • Fri 7

    Grand Rounds April 7, 2023: A Nudge Towards Cardiovascular Health: Incorporating Insights from Behavioral Science to Improve Cardiovascular Care Delivery (Srinath Adusumalli, MD, MSHP, MBMI, FACC)

    April 7, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Srinath Adusumalli, MD, MSHP, MBMI, FACC Adjunct Assistant Professor of Medicine Adjunct Professor of Healthcare Management Perelman School of Medicine and The Wharton School University of Pennsylvania Senior Medical […]

  • Fri 14

    Grand Rounds April 14, 2023: RECOVER in Action: Status of Clinical Trial Protocols (Kanecia Zimmerman, MD, PhD, MPH)

    April 14, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Kanecia Zimmerman, MD, PhD, MPH Associate Professor of Pediatrics Duke Clinical Research Institute Duke University School of Medicine Topic: RECOVER in Action: Status of Clinical Trial Protocols Date: Friday, […]

  • Fri 21

    Grand Rounds April 21, 2023: Personalised Cooler Dialysate for Patients Receiving Maintenance Haemodialysis (MyTEMP): A Pragmatic, Cluster-randomised Trial (Amit Garg, MD, MA, FRCPC, FACP, PhD; Stephanie N. Dixon, PhD, MSc)

    April 21, 2023 @ 1:00 pm - 2:00 pm

    Speakers: Amit Garg, MD, MA (Education) FRCPC, FACP, PhD Associate Dean, Clinical Research, Schulich School of Medicine and Dentistry Past President, Canadian Society of Nephrology Lead, Institute for Clinical Evaluative […]

  • Fri 28

    Grand Rounds April 28, 2023: Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation: An Embedded Cluster-crossover Trial (Matthew W. Semler, MD, MSc)

    April 28, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Matthew W. Semler, M.D., M.Sc. Assistant Professor of Medicine and Biomedical Informatics Medical Director, VICTR Center for Learning Healthcare Vanderbilt University Medical Center Topic: Oxygen-Saturation Targets for Critically Ill […]

  • May 2023

  • Fri 5

    Grand Rounds May 5, 2023: All of Us Research Program: Improving Health Through Diverse Technology, Huge Cohorts, and Precision Medicine (Joshua C. Denny, MD, MS)

    May 5, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Joshua C. Denny, MD, MS CEO, All of Us Research Program National Institutes of Health Bethesda, MD Topic: All of Us Research Program: Improving Health Through Diverse Technology, Huge Cohorts, and Precision Medicine Date: Friday, May 5, 2023, 1:00-2:00 p.m. ET To join the online meeting: Click the Zoom Meeting link below: https://duke.zoom.us/j/96153659804?pwd=VmNJVDE5VmtFbUFHY0lZeTM1K0Y5QT09 Meeting […]

  • Fri 12

    Grand Rounds May 12, 2023: Design and Pragmatic Trial of COACH: A Patient Portal/EHR Information System for Home Blood Pressure Monitoring in Hypertension (Richelle J. Koopman, MD, MS)

    May 12, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Richelle J. Koopman, MD, MS Professor and Vice Chair for Research and Faculty Affairs Jack M. and Winifred S. Colwill Endowed Professor Department of Family and Community Medicine University of Missouri Topic: Design and Pragmatic Trial of COACH: A Patient Portal/EHR Information System for Home Blood Pressure Monitoring in Hypertension Date: Friday, May 12, […]

  • Fri 19

    Grand Rounds May 19, 2023: Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis After a Fracture (Robert O’Toole, MD)

    May 19, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Robert O’Toole, MD Chief of Orthopaedics, R Adams Cowley Shock Trauma Center Head, Division of Orthopaedic Trauma Department of Orthopaedics Director, Clinical Research, Department of Orthopaedics University of Maryland School of Medicine Topic: Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis After a Fracture Date: Friday, May 19, 2023, 1:00-2:00 p.m. ET To join the online […]

  • June 2023

  • Fri 2

    Grand Rounds June 2, 2023: PROACT Xa and the Wizard of Oz: Behind the Curtain of a Pragmatic Decentralized Clinical Trial (John Alexander, MD, MHS)

    June 2, 2023 @ 1:00 pm - 2:00 pm

    Speaker: John Alexander, MD, MHS Professor of Medicine/Cardiology DCRI/Duke University Topic: PROACT Xa and the Wizard of Oz: Behind the Curtain of a Pragmatic Decentralized Clinical Trial Date: Friday, June 2, 2023, 1:00-2:00 p.m. ET To join the online meeting: Click the Zoom Meeting link below: https://duke.zoom.us/j/96153659804?pwd=VmNJVDE5VmtFbUFHY0lZeTM1K0Y5QT09 Meeting ID: 961 5365 9804 Passcode: 12345 One […]

  • Fri 9

    Grand Rounds June 9, 2023: Emulating Randomized Clinical Trials with Non-randomized Real-world Evidence Studies: Results From The RCT DUPLICATE Initiative (Shirley V. Wang, PhD)

    June 9, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Shirley V. Wang, PhD Associate Professor Division of Pharmacoepidemiology and Pharmacoeconomics Brigham and Women’s Hospital Harvard Medical School Topic: Emulating Randomized Clinical Trials with Non-randomized Real-world Evidence Studies: Results From The RCT DUPLICATE Initiative Date: Friday, June 9, 2023, 1:00-2:00 p.m. ET To join the online meeting: Click the Zoom Meeting link below: https://duke.zoom.us/j/96153659804?pwd=VmNJVDE5VmtFbUFHY0lZeTM1K0Y5QT09 […]

  • Fri 16

    Grand Rounds June 16, 2023: BeatPain Utah Pragmatic Clinical Trial: Partnering with Community Health Centers Within a Socio-Technical Framework (Julie Fritz, PT, PhD, FAPTA; Guilherme Del Fiol, MD, PhD)

    June 16, 2023 @ 1:00 pm - 2:00 pm

    Speakers: Julie Fritz, PT, PhD, FAPTA Distinguished Professor, Department of Physical Therapy & Athletic Training Associate Dean for Research, College of Health University of Utah Guilherme Del Fiol, MD, PhD Professor, Biomedical Informatics University of Utah Topic: BeatPain Utah Pragmatic Clinical Trial: Partnering with Community Health Centers Within a Socio-Technical Framework Date: Friday, June 16, […]

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