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Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • December 2023

  • Wed 6

    NIH Clinical Center Grand Rounds: “The Ethics Of ‘Other Motivations’ for Seeking Care and Enrolling in Research”

    December 6, 2023 @ 12:00 pm - 1:00 pm

    NIH Clinical Center Grand Rounds "The Ethics of 'Other Motivations' for Seeking Care and Enrolling in Research" William Gahl, MD, PhD Senior Investigator, National Human Genome Research Institute (NHGRI) https://videocast.nih.gov/watch=53801

  • Fri 8

    Grand Rounds December 8, 2023: A Pragmatic Randomized Trial of the Jumpstart Intervention to Promote Communication About Goals of Care for Hospitalized Patients with Serious Illness (Ruth Engelberg, PhD; Erin Kross, MD; Robert Lee, MD, MS)

    December 8, 2023 @ 1:00 pm - 2:00 pm

    Speakers: Ruth Engelberg PhD Research Professor of Medicine Division of Pulmonary, Critical Care and Sleep Medicine University of Washington Erin Kross MD, Associate Professor of Medicine, Division of Pulmonary, Critical […]

  • Fri 15

    Grand Rounds December 15, 2023: Diversifying Clinical Trials:  A Path Forward (Roxana Mehran, MD)

    December 15, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Roxana Mehran, MD Icahn School of Medicine at Mount Sinai Title: Diversifying Clinical Trials:  A Path Forward Date: Friday, December 15, 2023, 1:00-2:00 p.m. ET To join the online […]

  • Fri 22

    Grand Rounds December 22, 2023: No Presentation (Holiday)

    December 22, 2023 @ 1:00 pm - 2:00 pm
  • Fri 29

    Grand Rounds December 29, 2023: No Presentation (Holiday)

    December 29, 2023 @ 1:00 pm - 2:00 pm
  • January 2024

  • Fri 5

    Grand Rounds Biostatistics Series January 5, 2024: Methods for Handling Missing Data in Cluster Randomized Trials (Rui Wang, PhD; Moderator: Fan Li, PhD)

    January 5, 2024 @ 1:00 pm - 2:00 pm

    Speaker: Rui Wang, PhD Associate Professor of Population Medicine and Associate Professor in the Department of Biostatistics, Harvard Pilgrim Health Care Institute and Harvard Medical School Moderator: Fan Li, PhD […]

  • Fri 12

    Grand Rounds January 12, 2024: Design And Implementation Of A Weighted Lottery To Equitably Allocate Scarce COVID-19 Resources (Erin K. McCreary, PharmD, BCIDP)

    January 12, 2024 @ 1:00 pm - 2:00 pm

    Speaker: Erin K. McCreary, PharmD, BCIDP Director of Infectious Diseases Improvement and Clinical Research Innovation, UPMC Clinical Assistant Professor of Medicine, University of Pittsburgh President-Elect, Society of Infectious Diseases Pharmacists […]

  • Fri 19

    Grand Rounds January 19, 2024: Why Are Imaging RCTs Different? Lessons From Chest Pain Evaluation Trials (Pamela S. Douglas, MD, MACC, FASE, FAHA)

    January 19, 2024 @ 1:00 pm - 2:00 pm

    Speaker: Pamela S. Douglas, MD, MACC, FASE, FAHA Ursula Geller Professor of Research in Cardiovascular Diseases Duke Clinical Research Institute - Duke University Past President, American College of Cardiology Past […]

  • Fri 26

    Grand Rounds January 26, 2024: Advancing the Safe, Effective, and Equitable Use of AI in Healthcare (Suresh Balu, MD, MBA; Mark Sendak, MD, MPP)

    January 26, 2024 @ 1:00 pm - 2:00 pm

    Speakers: Suresh Balu, MD, MBA Director, Duke Institute for Health Innovation (DIHI) Associate Dean, Innovation and Partnership Duke School of Medicine Mark Sendak, MD, MPP Population Health & Data Science […]

  • February 2024

  • Fri 2

    Grand Rounds February 2, 2024: Strategies for Improving Public Understanding of the FDA and the Products It Regulates: Why Should We Care, and What Might We Do? (Susan C. Winckler, RPh, Esq)

    February 2, 2024 @ 1:00 pm - 2:00 pm

    Speaker: Susan C. Winckler, RPh, Esq Chief Executive Officer Reagan-Udall Foundation for the FDA Title: Strategies for Improving Public Understanding of the FDA and the Products It Regulates: Why Should […]

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