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Living Textbook of
Pragmatic Clinical Trials

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Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • October 2023

  • Fri 27

    Grand Rounds October 27, 2023: Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial (Harlan M. Krumholz, MD, SM)

    October 27, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Harlan M. Krumholz, MD, SM Harold H. Hines, Jr. Professor of Medicine Department of Internal Medicine Section of Cardiovascular Medicine Yale University School of Medicine Director, Yale-New Haven Hospital […]

  • November 2023

  • Fri 3

    Grand Rounds Biostatistics Series November 3, 2023: The Perils and Pitfalls of Complex Clustering in Pragmatic Trials (Jonathan Moyer, PhD; Moderator: Andrea Cook, PhD)

    November 3, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Jonathan C. Moyer, PhD Statistician, NIH Office of Disease Prevention Moderator: Andrea J. Cook, PhD Senior Biostatistics Investigator, Kaiser Permanente Washington Health Research Institute Topic: The Perils and Pitfalls […]

  • Fri 10

    Grand Rounds November 10, 2023: No Presentation (Holiday)

    November 10, 2023 @ 1:00 pm - 2:00 pm
  • Fri 17

    Grand Rounds November 17, 2023: Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results from the Nudge Study (Michael Ho, MD, PhD; Sheana Bull, PhD)

    November 17, 2023 @ 1:00 pm - 2:00 pm

    Speakers: Michael Ho, MD, PhD University of Colorado Sheana Bull, PhD University of Colorado Topic: Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results from […]

  • Fri 24

    Grand Rounds November 24, 2023: No Presentation (Holiday)

    November 24, 2023 @ 1:00 pm - 2:00 pm
  • Tue 28

    Exploratory and Inferential Spatial Statistical Methods: Tools To Understand the Geography of Health Across the U.S.

    November 28, 2023 @ 1:00 pm - 3:00 pm

    Presenter Lori Philip Tabb, PhD Associate Professor of Biostatistics Drexel University’s Dornsife School of Public Health About the Webinar Exploratory and inferential spatial statistical methods are the tools needed to […]

  • December 2023

  • Fri 1

    Grand Rounds Biostatistics Series December 1, 2023: Guidelines for Design and Analysis of Stepped-Wedge Trials (Jim Hughes, PhD; Moderator: Patrick Heagerty, PhD)

    December 1, 2023 @ 1:00 pm - 2:00 pm

    Speaker: James P. Hughes, PhD Professor Emeritus of Biostatistics, University of Washington Moderator: Patrick J. Heagerty, PhD Professor of Biostatistics, University of Washington Topic: Guidelines for Design and Analysis of Stepped-Wedge Trials Date: Friday, December 1, 2023, 1:00-2:00 p.m. ET To join the online meeting: Click the Zoom Meeting link below: https://duke.zoom.us/j/97816533886?pwd=MnRQUUVpTnpnZnF6MTFIdmRkazJpZz09 Meeting ID: 978 […]

  • Wed 6

    NIH Clinical Center Grand Rounds: “The Ethics Of ‘Other Motivations’ for Seeking Care and Enrolling in Research”

    December 6, 2023 @ 12:00 pm - 1:00 pm

    NIH Clinical Center Grand Rounds "The Ethics of 'Other Motivations' for Seeking Care and Enrolling in Research" William Gahl, MD, PhD Senior Investigator, National Human Genome Research Institute (NHGRI) https://videocast.nih.gov/watch=53801

  • Fri 8

    Grand Rounds December 8, 2023: A Pragmatic Randomized Trial of the Jumpstart Intervention to Promote Communication About Goals of Care for Hospitalized Patients with Serious Illness (Ruth Engelberg, PhD; Erin Kross, MD; Robert Lee, MD, MS)

    December 8, 2023 @ 1:00 pm - 2:00 pm

    Speakers: Ruth Engelberg PhD Research Professor of Medicine Division of Pulmonary, Critical Care and Sleep Medicine University of Washington Erin Kross MD, Associate Professor of Medicine, Division of Pulmonary, Critical […]

  • Fri 15

    Grand Rounds December 15, 2023: Diversifying Clinical Trials:  A Path Forward (Roxana Mehran, MD)

    December 15, 2023 @ 1:00 pm - 2:00 pm

    Speaker: Roxana Mehran, MD Icahn School of Medicine at Mount Sinai Title: Diversifying Clinical Trials:  A Path Forward Date: Friday, December 15, 2023, 1:00-2:00 p.m. ET To join the online […]

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