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Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

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  • September 2016

  • Fri 30

    Dig If You Will the Picture of the NIH Collaboratory

    September 30, 2016 @ 1:00 pm - 2:00 pm

    Presenter: Weinfurt, Kevin Slides: Slides Video: Grand-Rounds-09-30-16

  • October 2016

  • Fri 7

    Chlorthalidone versus Hydrochlorothiazide: A New Kind of VA Cooperative Study

    October 7, 2016 @ 1:00 pm - 2:00 pm

    Presenter: Lederle, Frank Slides: Slides Video: Grand-Rounds-10-07-16

  • Fri 14

    Multidisciplinary Chronic Pain Management in Primary Care: Paradox or Paradigm?

    October 14, 2016 @ 1:00 pm

    Presenter: Elder, Charles Slides: Slides Video: Grand-Rounds-10-14-16

  • Fri 21

    Demographics, Subgroup Analyses, and Statistical Considerations in Cluster-Randomized Trials

    October 21, 2016 @ 1:00 pm - 2:00 pm

    Presenter: Anderson, Monique Slides: Slides Video: Grand-Rounds-10-21-16

  • Fri 28

    Research on Medical Practices: Willingness to Participate and the Investigational Misconception

    October 28, 2016 @ 1:00 pm - 2:00 pm

    Presenter: Wilfond, Benjamin Slides: Slides Video: Grand-Rounds-10-28-16

  • November 2016

  • Fri 4

    Colorectal Cancer Screening in Primary Care: A Focus on STOP CRC

    November 4, 2016 @ 1:00 pm - 2:00 pm

    Presenter: Green, Beverly Slides: Slides Video: Grand-Rounds-11-04-16

  • Fri 11

    Recommendations from the Clinical Trials Transformation Initiative’s Data Monitoring Committee Project

    November 11, 2016 @ 1:00 pm - 2:00 pm

    Presenter: DeMets, Dave Slides: Slides Video: Grand-Rounds-11-11-16

  • Fri 18

    Lumbar Imaging with Reporting of Epidemiology (LIRE): The Beginning of the End (or The End of the Beginning?)

    November 18, 2016 @ 1:00 pm - 2:00 pm

    Presenter: Heagerty, Patrick Slides: Slides Video: Grand-Rounds-11-18-16

  • December 2016

  • Fri 2

    Lessons Learned from the NIH Collaboratory Biostatistics and Design Core

    December 2, 2016 @ 1:00 pm - 2:00 pm

    Presenter: Cook, Andrea Slides: Slides Video: Grand-Rounds-12-02-16

  • Fri 9

    Data Sharing in Pragmatic Trials: Balancing Transparency and Health System Privacy

    December 9, 2016 @ 1:00 pm - 2:00 pm

    Presenter: Simon, Gregory Slides: Slides Video: Grand-Rounds-12-09-16

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