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Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

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  • December 2016

  • Fri 16

    Comparison of Different Approaches for Notification and Authorization in Pragmatic Clinical Research Evaluating Commonly Used Medical Practices

    December 16, 2016 @ 1:00 pm - 2:00 pm

    Presenter: Weinfurt, Kevin Slides: Slides Video: Grand-Rounds-12-16-16

  • January 2017

  • Fri 6

    21st Century Cures Overview and Implications

    January 6, 2017 @ 1:00 pm - 2:00 pm

    Presenter: Daniel, Gregory Slides: Slides Video: Grand-Rounds-01-06-17

  • Fri 13

    What’s Next: People-Powered Knowledge Generation from Digital Health Data

    January 13, 2017 @ 1:00 pm - 2:00 pm

    Presenter: Krumholz, Harlan Slides: Slides Video: Grand-Rounds-01-13-17

  • Fri 20

    What “High Utilizers” Can Tell Us About Population Health

    January 20, 2017 @ 1:00 pm - 2:00 pm

    Presenter: Labby, David Slides: Slides Video: Grand-Rounds-01-20-17

  • Fri 27

    Connecting the Dots: Behavioral Economics and a Cluster Randomized Trial

    January 27, 2017 @ 1:00 pm - 2:00 pm

    Presenter: Hernandez, Adrian Slides: Slides Video: Grand-Rounds-01-27-17

  • February 2017

  • Fri 3

    A Tentative Introduction to the Revised Common Rule for the Protection of Human Subjects

    February 3, 2017 @ 1:00 pm - 2:00 pm

    Presenter: Sugarman, Jeremy Slides: Slides Audio: Grand-Rounds-02-03-17

  • Fri 10

    INVESTED Vanguard Year: What Did We Learn About SMART IRB?

    February 10, 2017 @ 1:00 pm - 2:00 pm

    Presenter: Cobb, Nichelle Slides: Slides Video: Grand-Rounds-02-10-17

  • Fri 17

    Healthier Together: Collaborative Networks of Patients, Clinicians and Researchers Creating Learning Health Systems

    February 17, 2017 @ 1:00 pm - 2:00 pm

    Presenter: Margolis, Peter Slides: Slides Video: Grand-Rounds-02-17-17

  • Fri 24

    Where Are We On Our Path to Digital Healthcare (And Why Is It So Hard?)

    February 24, 2017 @ 1:00 pm - 2:00 pm

    Presenter: Wachter, Robert Slides: Slides Video: Grand-Rounds-02-24-17

  • March 2017

  • Fri 3

    Showcasing Innovative Operational and Recruitment Approaches in the ADAPTABLE Trial

    March 3, 2017 @ 1:00 pm - 2:00 pm

    Presenter: Roe, Matthew Slides: Slides Video: Grand-Rounds-03-03-17

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