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Living Textbook of
Pragmatic Clinical Trials

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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Interpretation, Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Collaborating With Health System Partners to Review and Understand Trial Results
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
8 events found.

Events

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  • October 2026

  • Fri 2

    Grand Rounds October 2, 2026: Self-Directed Versus Clinician-Delivered Cognitive Behavioral Therapy for Chronic Pain: Results From the COPES ExTRA Pragmatic Trial (Alicia Heapy, PhD; Diana Higgins, PhD)

    October 2 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/98923781799?pwd=AqCbAOocnvKyCyXvEdXZPHd8D02SLn.1 Passcode: 305323 Title: Self-Directed Versus Clinician-Delivered Cognitive Behavioral Therapy for Chronic Pain: Results From the COPES ExTRA Pragmatic Trial Speakers: Alicia Heapy, PhD Associate Professor Yale […]

  • Fri 9

    Grand Rounds October 9, 2026: An End-to-End Agentic AI Platform to Automate Clinical Trials: A Proof-of-Concept and Evaluation Study (Christoph Hornik, MD, PhD, MPH; Moulik Shah)

    October 9 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/97443456904?pwd=a712IZGginKaNIkc2ENFublvtQx03G.1 Passcode: 982217 Title: An End-to-End Agentic AI Platform to Automate Clinical Trials: A Proof-of-Concept and Evaluation Study Speakers: Christoph Hornik, MD, PhD, MPH Duke Clinical Research […]

  • Fri 16

    Grand Rounds October 16, 2026: Catalyzing Change: How First-in-Patient Trials Can Fix US Clinical Trials (Adrian F. Hernandez, MD, MHS)

    October 16 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/95723385335?pwd=t3cjWSmG32m4iiBYSb7NrcgaqpEvWb.1 Passcode: 801123 Title: Catalyzing Change: How First-in-Patient Trials Can Fix US Clinical Trials Speaker: Adrian F. Hernandez, MD, MHS Vice Dean and Executive Director Duke Clinical […]

  • Fri 23

    Grand Rounds October 23, 2026: Agentic AI in Cardiovascular Care Delivery: UpDoc’s Approach to ARPA-H ADVOCATE (Daniel Yazdi, MD, MS)

    October 23 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/98160250296?pwd=x9NU9Gaa2OFB4wl6gjEAhlrWBtd113.1 Passcode: 821753 Title: Agentic AI in Cardiovascular Care Delivery: UpDoc’s Approach to ARPA-H ADVOCATE Speaker: Daniel Yazdi, MD, MS Clinical Product Lead, UpDoc Cardiologist Cedars-Sinai Date: […]

  • Fri 30

    Grand Rounds October 30, 2026: A Pragmatic Trial of Family-Focused Prevention in Pediatric Primary Care: Successes, Challenges, and Lessons Learned – Guiding Good Choices for Health (Margaret Kuklinski, PhD; Stacy Sterling, DrPH, MSW)

    October 30 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/93513391305?pwd=Fq6rh0gDCDrJpJNwUPcOmCQI8C87UZ.1 Passcode: 765343 Title: A Pragmatic Trial of Family-Focused Prevention in Pediatric Primary Care: Successes, Challenges, and Lessons Learned – Guiding Good Choices for Health Speakers: Margaret […]

  • November 2026

  • Fri 6

    Grand Rounds November 6, 2026: Boosting Peri-Operative Pain Care: Mixed Results (and Myriad Implications) From the NOHARM Pragmatic Trial (Andrea Cheville, MD; Jon Tilburt, MD)

    November 6 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/99709582501?pwd=gmjjG7to1pcmu0QunnFThnqiNAgwn6.1 Passcode: 667807 Title: Boosting Peri-Operative Pain Care: Mixed Results (and Myriad Implications) From the NOHARM Pragmatic Trial Speakers: Andrea Cheville, MD Physiatrist Mayo Clinic Jon Tilburt, […]

  • Fri 13

    Grand Rounds November 13, 2026: Physician Edits to AI-Drafted Patient Messages and Their Impact on Clinical Workload (Lily Poursoltan, MS, PhD)

    November 13 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/99843065000?pwd=wfMK8HjSbanr1q3wI8YA0OcgmidbYn.1  Passcode: 983393 Title: Physician Edits to AI-Drafted Patient Messages and Their Impact on Clinical Workload Speaker: Lily Poursoltan, MS, PhD PhD Candidate, UC San Diego Data […]

  • Fri 20

    Grand Rounds November 20, 2026: Ranking or Weighting? Rethinking the Analytic Approach by Incorporating the Patient’s Voice in the Composite Endpoint (Huiman Barnhart, PhD; Shelby Reed, PhD)

    November 20 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/98092317467?pwd=V6V3H9erBLh8TECady3rtadavNpDaQ.1 Passcode: 782922 Title: Ranking or Weighting? Rethinking the Analytic Approach by Incorporating the Patient’s Voice in the Composite Endpoint Speakers: Huiman Barnhart, PhD Duke Clinical Research […]

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