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NIH Collaboratory
Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
86 events found.

Events

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  • September 2020

  • Fri 25

    Grand Rounds September 25: Accelerating the Nation’s COVID-19 Testing Capacity: An Update from the NIH’s RADx Program

    September 25, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Rick Bright, PhD Senior Advisor to the NIH Director Rachael Fleurence, PhD Special Assistant to the NIH Director for COVID-19 Diagnostics Topic: Accelerating the Nation’s COVID-19 Testing Capacity: An Update from the NIH’s RADx Program Date: Friday, September 25, 2020, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed […]

  • October 2020

  • Fri 2

    Grand Rounds October 2: Driving Toward Health Impact: Our Journey and Path Forward

    October 2, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Nakela L. Cook, MD, MPH Executive Director PCORI Topic: Driving Toward Health Impact: Our Journey and Path Forward Date: Friday, October 2, 2020, 1:00-2:00 p.m. ET Meeting Info: To […]

  • Fri 9

    Grand Rounds October 9: Pragmatic Trial of Higher vs. Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis (HiLo)

    October 9, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Myles Wolf, MD, MMSc Division of Nephrology, Department of Medicine Duke Clinical Research Institute Duke University School of Medicine Topic: Pragmatic Trial of Higher vs. Lower Serum Phosphate Targets […]

  • Thu 15

    October 15, 2020: NIA IMPACT Collaboratory Grand Rounds: The AHRQ and Lancet Reports on Dementia Interventions: Interpretation and Implications for Embedded Pragmatic Trials

    October 15, 2020 @ 12:00 pm - 1:00 pm

    Presenters: Joe Gaugler, PhD Robert L. Kane Endowed Chair in Long-Term Care and Aging Professor, University of Minnesota Associate Core Leader, IMPACT Implementation Core Eric Larson, MD, MPH Vice President, […]

  • Fri 16

    Grand Rounds October 16: Back to School, It’s More Than Just a Trip to Target This Year: The ABC Science Collaborative

    October 16, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Danny Benjamin, MD, PhD Kiser-Arena Distinguished Professor of Pediatrics, Duke University Chair, Pediatric Trials Network Deputy Director, Duke Clinical Research Institute Topic: Back to School, It’s More Than Just […]

  • Fri 23

    Grand Rounds October 23: Outpatient Clinical Decision Support – An Evidence-Based Implementation Framework

    October 23, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Patrick O'Connor, MD, MA, MPH Senior Clinical Investigator HealthPartners Institute JoAnn Sperl-Hillen, MD Senior Clinical Investigator HealthPartners Institute Topic: Outpatient Clinical Decision Support - An Evidence Based Implementation Framework […]

  • Tue 27

    October 27-30: Simplifying Informed Consent – OHRP Virtual Workshop at the NIH Office of Extramural Research Fall Regional Seminar

    October 27, 2020 @ 8:00 am - October 30, 2020 @ 5:00 pm

    The NIH Office of Extramural Research (OER) will host its semi-annual regional seminar virtually this fall from October 27-30. Registration is required, and the event is free. Mark your calendars […]

  • Fri 30

    Grand Rounds October 30: Lessons from Virtual Trials in Time of a Pandemic: Minnesota Hydroxychloroquine Experience

    October 30, 2020 @ 1:00 pm - 2:00 pm

    Speaker: David R. Boulware MD, MPH Professor of Medicine Infectious Disease & International Medicine Department of Medicine University of Minnesota Topic: Lessons from Virtual Trials in Time of a Pandemic: Minnesota Hydroxychloroquine Experience Date: Friday, October 30, 2020, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal […]

  • November 2020

  • Fri 6

    Grand Rounds November 6: Appendectomy vs Antibiotics for Appendicitis-Early Results from the CODA trial

    November 6, 2020 @ 1:00 pm - 2:00 pm

    Speaker: David R. Flum, MD, MPH Professor, Surgery, Health Services, and Pharmacy Associate Chair for Research, Department of Surgery University of Washington Topic: Appendectomy vs Antibiotics for Appendicitis-Early Results from the CODA trial Date: Friday, November 6, 2020, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications […]

  • Fri 13

    Grand Rounds November 13: Pragmatic and Explanatory Attitudes to RCTs: Using the PRECIS-2 Tool to Describe the Design of the MyTEMP Trial

    November 13, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Ahmed Al-Jaishi, PhD (candidate) Health Research Methodology McMaster University Amit Garg, MD, PhD Professor, Department of Medicine Epidemiology & Biostatistics Western University, London, Canada Senior Core Scientist, Site Director, and Program Lead ICES Western Kidney Dialysis & Transplantation Research Program, London, Canada Nephrologist, London Health Sciences Centre Victoria Hospital, London, Canada Merrick Zwarenstein,  MBBCh, […]

  • Thu 19

    NIA IMPACT Collaboratory Grand Rounds: Implementation Outcomes: Their Role in Treatment Success

    November 19, 2020 @ 12:00 pm - 1:00 pm

    Presenter: Enola Proctor, PhD Shanti K. Khinduka Distinguished Professor Emeritus Brown School Washington University, St. Louis Zoom Details: Please click the link below to join the webinar: https://hebrewseniorlife.zoom.us/j/97344810673 Webinar ID: 973 4481 0673 International numbers available: https://hebrewseniorlife.zoom.us/u/ac4bYFtynq

  • Fri 20

    Grand Rounds November 20: Drug Development in Kidney Disease: Proceedings from a Multi-Stakeholder Panel

    November 20, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Daniel Edmonston, MD Medical Instructor Duke University School of Medicine Topic: Drug Development in Kidney Disease: Proceedings from a Multi-Stakeholder Panel Date: Friday, November 20, 2020, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files, go to https://dukemed.webex.com/dukemed/systemdiagnosis.php. To join the […]

  • December 2020

  • Fri 4

    Grand Rounds December 4: The Yale New Haven Health System as an Evidence Generation Ecosystem for Heart Failure

    December 4, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Tariq Ahmad, MD, MPH Director, Advanced Heart Failure Program Yale School of Medicine and Yale New Haven Health Topic: The Yale New Haven Health System as an Evidence Generation Ecosystem for Heart Failure Date: Friday, December 4, 2020, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF […]

  • Fri 11

    Grand Rounds December 11: PREVENTABLE: Starting a Pragmatic Trial in a Pandemic

    December 11, 2020 @ 1:00 pm - 2:00 pm

    Speakers: Karen P. Alexander, MD Professor of Medicine/Cardiology Duke University School of Medicine W. Schuyler Jones, MD Associate Professor of Medicine/Cardiology Duke University School of Medicine Topic: PREVENTABLE: Starting a Pragmatic Trial in a Pandemic Date: Friday, December 11, 2020, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for […]

  • Thu 17

    NIA IMPACT Collaboratory Grand Rounds: Improving Serious Illness Care Through Large Pragmatic Trials

    December 17, 2020 @ 12:00 pm - 1:00 pm

    Presenter: Scott Halpern, MD, PhD John M. Eisenberg Professor of Medicine, Epidemiology, and Medical Ethics and Health Policy University of Pennsylvania Zoom Details: Please click the link below to join the webinar: https://hebrewseniorlife.zoom.us/j/97344810673 Webinar ID: 973 4481 0673 International numbers available: https://hebrewseniorlife.zoom.us/u/ac4bYFtynq

  • Fri 18

    Grand Rounds December 18: The SAMSON Trial: An N-of-1 Trial of Statin, Placebo, and No Treatment to Assess Patient Symptoms

    December 18, 2020 @ 1:00 pm - 2:00 pm

    Speaker: Matthew Shun-Shin BMBCh, PhD Imperial College London Topic: The SAMSON Trial: An N-of-1 Trial of Statin, Placebo, and No Treatment to Assess Patient Symptoms Date: Friday, December 18, 2020, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files, go to https://dukemed.webex.com/dukemed/systemdiagnosis.php. […]

  • Fri 25

    Grand Rounds December 25: No Presentation (Holiday Break)

    December 25, 2020 @ 1:00 pm - 2:00 pm
  • January 2021

  • Fri 1

    Grand Rounds January 1: No Presentation (New Year’s Day)

    January 1, 2021 @ 1:00 pm - 2:00 pm
  • Fri 8

    Grand Rounds January 8: HERO-Together: Building Vaccine Confidence With Long-Term Outcomes Data

    January 8, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Emily O’Brien, PhD, FAHA Associate Professor Duke Clinical Research Institute Duke University School of Medicine Department of Population Health Sciences Topic: HERO-Together: Building Vaccine Confidence With Long-Term Outcomes Data […]

  • Wed 13

    National Advisory Council on Aging: “COVID in US Nursing Homes: The Power of Data”

    January 13, 2021 @ 12:15 pm - 12:45 pm

    Live videocast of Vince Mor, PhD presenting at the National Advisory Council on Aging: "COVID in US Nursing Homes: The Power of Data" Join the live videocast on Wednesday, January […]

  • Fri 15

    Grand Rounds January 15: How CTTI & the Clinical Trials Community Have Risen to Meet the Challenge of the COVID-19 Pandemic

    January 15, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Pamela Tenaerts, MD, MBA Executive Director Clinical Trials Transformation Initiative Topic: How CTTI & the Clinical Trials Community Have Risen to Meet the Challenge of the COVID-19 Pandemic Date: […]

  • Thu 21

    NIA IMPACT Collaboratory Grand Rounds January 21: Implementation in Ongoing AD/ADRD ePCTS in Different Health Care Settings Using Real Examples

    January 21, 2021 @ 12:00 pm - 1:00 pm

    Presenters: Ab Brody, PhD, RN, FAAN New York University Rory Meyers College of Nursing Ellen McCreedy, PhD, MPH Brown University School of Public Health Jessica Colburn, MD Johns Hopkins University […]

  • Fri 22

    Grand Rounds January 22: Is It Time to Embrace Preprints? A Conversation About the First 18 Months of medRxiv

    January 22, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Harlan M. Krumholz, MD, SM Harold H. Hines, Jr. Professor of Medicine and Public Health Yale University Joseph S. Ross, MD, MHS Professor of Medicine and Public Health Yale […]

  • Fri 29

    Grand Rounds January 29: The COVID-19 Citizen Science Study

    January 29, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Gregory M. Marcus, MD, MAS Professor of Medicine University of California, San Francisco Topic: The COVID-19 Citizen Science Study Date: Friday, January 29, 2021, 1:00-2:00 p.m. ET Meeting Info: […]

  • February 2021

  • Fri 5

    Grand Rounds February 5: Generating High-Quality Evidence During a Pandemic: The Brazilian COALITION Experience

    February 5, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Renato D. Lopes, MD, MHS, PhD Professor of Medicine Division of Cardiology Duke University Medical Center Duke Clinical Research Institute Brazilian Clinical Research Institute Topic: Generating High-Quality Evidence During […]

  • Fri 12

    Grand Rounds February 12: Leveraging RWD in a Multinational Trial: Results from the Other eHARMONY (HARMONY Outcomes EHR Ancillary Study)

    February 12, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Lesley Curtis, PhD Professor in Population Health Sciences Department of Population Health Sciences Duke University School of Medicine Brad Hammill, PhD Associate Professor in Population Health Sciences Department of […]

  • Thu 18

    NIA IMPACT Collaboratory Grand Rounds February 18: Ethical Challenges with Pragmatic RCTs – General Issues and Special Considerations in Dementia

    February 18, 2021 @ 12:00 pm - 1:00 pm

    Presenter: Stuart G. Nicholls, PhD Senior Clinical Research Associate Ottawa Hospital Research Institute Zoom Details: Please click the link below to join the webinar: https://hebrewseniorlife.zoom.us/j/97344810673 Webinar ID: 973 4481 0673 […]

  • Fri 19

    Grand Rounds February 19: Beyond Politics: Promoting COVID Vaccination in the US

    February 19, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Kevin A. Schulman, MD Professor of Medicine and Economics Stanford University Topic: Beyond Politics: Promoting COVID Vaccination in the US Date: Friday, February 19, 2021, 1:00-2:00 pm ET Meeting […]

  • Fri 26

    Grand Rounds February 26: Calibrating Real-World Evidence Against RCT Evidence: Early Learnings from RCT-DUPLICATE

    February 26, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Sebastian Schneeweiss, MD, ScD Chief, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital Professor of Medicine, Harvard Medical School Professor in Epidemiology, Harvard T.H. Chan School of Public Health Topic: Calibrating Real-World Evidence Against RCT Evidence: Early Learnings from RCT-DUPLICATE Date: Friday, February 26, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether […]

  • March 2021

  • Fri 5

    Grand Rounds March 5: Data and Safety Monitoring Boards for Trials of COVID-19 Vaccines: The Challenges

    March 5, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Susan S. Ellenberg, PhD Professor of Biostatistics, Medical Ethics, and Health Policy University of Pennsylvania Topic: Data and Safety Monitoring Boards for Trials of COVID-19 Vaccines: The Challenges Date: Friday, March 5, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media […]

  • Fri 12

    Grand Rounds March 12: Lessons Learned from the Gates MRI Virtual COVID-19 Trial

    March 12, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Mohamed Bassyouni, PharmD Product Development Program Leader Bill and Melinda Gates Medical Research Institute Cambridge, MA Jintanat Ananworanich, MD, PhD Clinical Development Leader Bill and Melinda Gates Medical Research Institute Cambridge, MA Topic: Lessons Learned from the Gates MRI Virtual COVID-19 Trial Date: Friday, March 12, 2021, 1:00-2:00 p.m. ET Meeting Info: To check […]

  • Thu 18

    NIA IMPACT Collaboratory Grand Rounds March 18: Updates on the IMPACT Pilot Studies

    March 18, 2021 @ 12:00 pm - 1:00 pm

    Presenters: Brent P. Forester, MD, MSc Chief, Center of Excellence in Geriatric Psychiatry McLean Hospital Medical Director, Behavioral Health, Evaluation, and Research Population Health Management Mass General Brigham Ula Hwang, […]

  • Fri 19

    Grand Rounds March 19: HERO–Learning Together about Vaccines for SARS-CoV-2

    March 19, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Emily O’Brien, PhD, FAHA Associate Professor Duke Clinical Research Institute Duke University School of Medicine Robert M. Califf, MD, MACC Head of Clinical Policy and Strategy Verily Life Sciences and Google Health Topic: HERO–Learning Together about Vaccines for SARS-CoV-2 Date: Friday, March 19, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you have […]

  • Fri 26

    Grand Rounds March 26: The Path to Preventive Genomics

    March 26, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Robert C. Green, MD, MPH Professor of Medicine (Genetics), Harvard Medical School Director, Genomes2People Research Program and Preventive Genomics Clinic Mass General Brigham, Ariadne Labs, Broad Institute Topic: The Path to Preventive Genomics Date: Friday, March 26, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal […]

  • April 2021

  • Fri 2

    Grand Rounds April 2: Lessons from COVID-19: The First Year of the REMAP-CAP Global Adaptive Platform Trial

    April 2, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Derek C. Angus, MD, MPH, FRCP Chief Healthcare Innovation Officer, UPMC Associate Vice Chancellor for Healthcare Innovation, University of Pittsburgh Schools of the Health Sciences Distinguished Professor and Mitchell P. Fink Endowed Chair Department of Critical Care Medicine, University of Pittsburgh and UPMC Topic: Lessons from COVID-19: The First Year of the REMAP-CAP Global […]

  • Fri 9

    Grand Rounds April 9: Taking Research to the Participant: Experiences with TREAT NOW, a No-Touch COVID-19 Trial

    April 9, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Adit Ginde, MD, MPH Professor and Vice Chair for Research, Department of Emergency Medicine Director of Clinical Research, Department of Anesthesiology Director, Colorado CTSI Trial Innovation Network Hub University of Colorado School of Medicine Topic: Taking Research to the Participant: Experiences with TREAT NOW, a No-Touch COVID-19 Trial Date: Friday, April 9, 2021, 1:00-2:00 […]

  • Thu 15

    NIA IMPACT Collaboratory Grand Rounds April 15: Inclusion, Diversity, and Equity in Pragmatic Clinical Trials

    April 15, 2021 @ 12:00 pm - 1:00 pm

    Presenters: Consuelo H. Wilkins, MD, MSCI Vice President for Health Equity Vanderbilt University Medical Center Professor of Medicine Vanderbilt School of Medicine Zoom Details: Please click the link below to […]

  • Fri 16

    Grand Rounds April 16: Minnesota EHR Consortium COVID-19 Project: A Statewide Collaboration to Inform Vaccine Equity

    April 16, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Paul E. Drawz, MD, MHS, MS Associate Professor Division of Renal Disease and Hypertension University of Minnesota Tyler N.A. Winkelman, MD, MSc Co-Director, Health, Homelessness, and Criminal Justice Lab Associate Director, Virtual Data Warehouse Hennepin Healthcare Research Institute Topic: Minnesota EHR Consortium COVID-19 Project: A Statewide Collaboration to Inform Vaccine Equity Date: Friday, April […]

  • Fri 23

    Grand Rounds April 23: COVID Clinical Trials: The Intermountain Healthcare Experience

    April 23, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Samuel M. Brown, MD, MS Associate Professor and Director of Pulmonary/Critical Care Research Intermountain Healthcare Associate Professor, University of Utah Topic: COVID Clinical Trials: The Intermountain Healthcare Experience Date: Friday, April 23, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media […]

  • Fri 30

    Grand Rounds April 30: ACTIV-6: A Direct-to-Participant Platform Trial of Repurposed Drugs for COVID-19 in Non-hospitalized Patients

    April 30, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Susanna Naggie, MD, MHS Associate Professor of Medicine Duke Clinical Research Institute Elizabeth Shenkman, PhD Chair, Department of Health Outcomes and Biomedical Informatics Co-Director, Clinical and Translational Science Institute […]

  • May 2021

  • Fri 7

    Grand Rounds May 7: Online Recruitment in the Era of COVID-19: Pitfalls and Progress

    May 7, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Megan L. Ranney, MD, MPH, FACEP Director, Brown-Lifespan Center for Digital Health Warren Alpert Endowed Associate Professor of Emergency Medicine, Brown University Associate Dean of Strategy and Innovation, School […]

  • Fri 14

    Grand Rounds Diversity Workshop Series May 14: Keynote Session: Diverse Representation Among Clinical Trial Participants: Why It Is Important and How Can We Improve

    May 14, 2021 @ 1:00 pm - 2:00 pm

    Guest Moderator: Kanecia Zimmerman, MD Associate Professor of Pediatrics Duke University School of Medicine Speaker: Clyde W. Yancy, MD, MSc, MACC, FAHA, MACP, FHFSA Vice Dean, Diversity and Inclusion Northwestern […]

  • Thu 20

    NIA IMPACT Collaboratory Grand Rounds May 20: Pilot and Feasibility Studies for Pragmatic Cluster Randomised Trials

    May 20, 2021 @ 12:00 pm - 1:00 pm

    Presenter: Claire Chan, MSc Statistician Institute of Population Health Sciences Queen Mary University of London Zoom Details: Please click the link below to join the webinar: https://hebrewseniorlife.zoom.us/j/97344810673 Webinar ID: 973 […]

  • Fri 21

    Grand Rounds May 21: The PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation in Trial Design and Delivery

    May 21, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Chris Butler, MD Nuffield Department of  Primary Care Health Sciences University of Oxford Ben Saville, PhD Berry Consultants Topic: The PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation […]

  • Fri 28

    Grand Rounds May 28: No Presentation (Memorial Day Holiday)

    May 28, 2021 @ 1:00 pm - 2:00 pm
  • June 2021

  • Fri 4

    Grand Rounds Diversity Workshop Series June 4: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Planning for Diversity – Stakeholder Engagement and Site Selection to Maximize Diversity

    June 4, 2021 @ 1:00 pm - 2:00 pm

    Guest Moderator: Wendy Weber, ND, PhD, MPH Chief, Clinical Research in Complementary and Integrative Health Branch Division of Extramural Research National Center for Complementary and Integrative Health (NCCIH) National Institutes […]

  • Fri 11

    Grand Rounds June 11: The TSOS Effectiveness-Implementation Hybrid Study: Health Care System Level Theoretical Considerations & Pragmatic Trial Results

    June 11, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Douglas Zatzick, MD Professor, Department of Psychiatry and Behavioral Sciences University of Washington School of Medicine Topic: The TSOS Effectiveness-Implementation Hybrid Study: Health Care System Level Theoretical Considerations & […]

  • Thu 17

    NIA IMPACT Collaboratory Grand Rounds June 17: Promises and Pitfalls of Existing Data in Nursing Homes

    June 17, 2021 @ 12:00 pm - 1:00 pm

    Presenters: Debra Saliba, MD, MPH Anna and Harry Borun Endowed Chair in Geriatrics and Gerontology at UCLA Director, UCLA/JH Borun Center for Gerontological Research Associate Director for Education, VA Los Angeles HSR&D Center of Innovation Senior Natural Scientist, RAND Corporation Joan M. Teno, MD, MS Professor of Medicine, Oregon Health & Science University Adjunct Professor […]

  • Fri 18

    Grand Rounds June 18: The MITIGATE Study: Insights from a Decentralized, Virtual, Electronic Health Record-Based Pragmatic Clinical Trial

    June 18, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Andrew P. Ambrosy, MD Research Scientist Cardiovascular and Metabolic Conditions Research Solution Through Technology and Advanced Analytic Research (STAR) Group Kaiser Permanente Northern California Division of Research Alan S. Go, MD Regional Medical Director, Clinical Trials Program Associate Director, Cardiovascular and Metabolic Conditions Research Director, Solutions Through Technology and Advanced Analytics Research (STAR) Group Topic: […]

  • Fri 25

    Grand Rounds Diversity Workshop Series June 25: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Meeting Participants Where They Are – Outreach, Trust, and Consent to Maximize Diversity

    June 25, 2021 @ 1:00 pm

    Guest Moderator: Emily O’Brien, PhD Associate Professor, Department of Population Health Sciences Duke Clinical Research Institute Duke University School of Medicine Panel: Jonathan Jackson, PhD Executive Director Community Access, Recruitment, and Engagement (CARE) Research Center Massachusetts General Hospital and Harvard Medical School Judith Schlaeger, PhD, CNM, LAc, FAAN Associate Professor, Department of Human Development Nursing […]

  • July 2021

  • Fri 2

    Grand Rounds July 2: No Presentation (Independence Day Holiday)

    July 2, 2021 @ 1:00 pm - 2:00 pm
  • Fri 9

    Grand Rounds July 9: COVID-19 Vaccine Efficacy Studies: Challenges and Successes

    July 9, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Hana El Sahly, MD Professor of Molecular Virology and Microbiology Baylor College of Medicine Houston, TX Topic: COVID-19 Vaccine Efficacy Studies: Challenges and Successes Date: Friday, July 9, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files, go to https://dukemed.webex.com/dukemed/systemdiagnosis.php. […]

  • Fri 16

    Grand Rounds Diversity Workshop Series July 16: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Maximizing Diversity in PCTs – What Can We Learn From Implementation Trials?

    July 16, 2021 @ 1:00 pm - 2:00 pm

    Guest Moderator: David Chambers, DPhil Deputy Director for Implementation Science Office of the Director in the Division of Cancer Control and Population Sciences (DCCPS) National Cancer Institute (NCI) National Institutes of Health (NIH) Panel: Amanda Midboe, PhD Center for Innovation to Implementation U.S. Department of Veterans Affairs Chair of the Implementation Science Work Group for […]

  • Fri 23

    Grand Rounds July 23: Long Term COVID Patient Engagement: Best Practices Informed By Patients’ Experiences Seeking Medical Care

    July 23, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Diana Berrent, JD Survivor Corps, Founder Natalie Lambert, PhD Associate Research Professor Indiana University School of Medicine Nick Guthe Survivor Corps Member and Advisor   Topic: Long Term COVID Patient Engagement: Best Practices Informed By Patients' Experiences Seeking Medical Care Date: Friday, July 23, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you […]

  • Fri 30

    Grand Rounds Diversity Workshop Series July 30: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Diversity in the PCT Ecosystem – How Do We Develop a Pipeline of Diverse Investigators and Leaders in PCTs?

    July 30, 2021 @ 1:00 pm - 2:00 pm

    Guest Moderator: Lesley Curtis, PhD Professor in Population Health Sciences Department of Population Health Sciences Duke University School of Medicine Panel: Marie A. Bernard, MD Acting NIH Chief Officer for Scientific Workforce Diversity Deputy Director, National Institute on Aging National Institutes of Health George A. Mensah, M.D., FACC Director, Center for Translation Research and Implementation […]

  • August 2021

  • Fri 6

    Grand Rounds August 6: The TOGETHER Early Treatment of COVID Trial: Building Platform Trial Infrastructure for Infectious Diseases

    August 6, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Edward Mills, PhD, FRCP Professor Department of Health Research Methods, Evidence & Impact McMaster University, Canada Topic: The TOGETHER Early Treatment of COVID Trial: Building Platform Trial Infrastructure for Infectious Diseases Date: Friday, August 6, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications […]

  • Fri 13

    Grand Rounds August 13: Got anything for this cough? Outpatient Treatment Trials in the Time of COVID

    August 13, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Davey Smith, MD Protocol Co-Chair ACTIV-2 Professor of Medicine, UC San Diego Topic: Got anything for this cough? Outpatient Treatment Trials in the Time of COVID Date: Friday, August 13, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files, go […]

  • Fri 20

    Grand Rounds August 20: Fluvoxamine for Early Treatment of COVID-19: The STOP COVID Clinical Trials

    August 20, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Eric Lenze, MD Wallace and Lucille K. Renard Professor of Psychiatry Washington University School of Medicine, St. Louis Topic: Fluvoxamine for Early Treatment of COVID-19: The STOP COVID Clinical Trials Date: Friday, August 20, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) […]

  • Fri 27

    Grand Rounds August 27: Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock: the DOREMI trial

    August 27, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Benjamin Hibbert, MD, PhD Clinician Scientist and Interventional Cardiologist University of Ottawa Heart Institute Topic: Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock: the DOREMI trial […]

  • September 2021

  • Fri 3

    Grand Rounds September 3: No Presentation (Labor Day Holiday)

    September 3, 2021 @ 1:00 pm - 2:00 pm
  • Fri 10

    Grand Rounds September 10: Effect of Salt Substitution on Cardiovascular Events and Death

    September 10, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Bruce Neal, MB ChB, PhD, FRCP, FAHA, FAHMS Executive Director, George Institute Australia Professor of Medicine, UNSW Sydney Honorary Professor, Sydney Medical School, University of Sydney Professor of Clinical […]

  • Fri 17

    Grand Rounds September 17: Population-based Outreach to Prevent Suicidal Behavior: A Pragmatic Randomized Trial

    September 17, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Gregory Simon, MD, MPH Senior Investigator Kaiser Permanente Washington Health Research Institute Susan M Shortreed, PhD Senior Investigator, Biostatistics Unit Kaiser Permanente Washington Health Research Institute Affiliate Professor, Department […]

  • Fri 24

    Grand Rounds September 24: Enabling Patient-Reported Outcome Measures in Clinical Trials, Exemplified by Cardiovascular Trials

    September 24, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Theresa Coles, PhD Assistant Professor Department of Population Health Sciences Duke University School of Medicine Kevin Weinfurt, PhD Professor and Vice Chair of Research Department of Population Health Sciences […]

  • October 2021

  • Fri 1

    Grand Rounds October 1: COVID-OUT: From Computer Modeling to a Phase III Trial of Early Outpatient Treatment for SARS-CoV-2 Infection

    October 1, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Carolyn Bramante, MD, MPH Division of General Internal Medicine Departments of Internal Medicine and Pediatrics Core faculty in the Program in Health Disparities Research and the Center for Pediatric […]

  • Fri 8

    Grand Rounds October 8: Lessons Learned and Patient Partnership in ADAPTABLE

    October 8, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Madelaine Faulkner Modrow, MPH Program Director Department of Epidemiology and Biostatistics University of California, San Francisco Schuyler Jones, MD Associate Professor of Medicine Duke University School of Medicine Topic: […]

  • Fri 15

    Grand Rounds October 15: The Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in Bangladesh

    October 15, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Jason Abaluck, PhD Professor of Economics Yale School of Management Topic: The Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in Bangladesh Date: Friday, October 15, 2021, 1:00-2:00 […]

  • Fri 22

    Grand Rounds October 22: The STAMP Trial: Increasing Engagement in Advance Care Planning and Lessons Learned from Partnering with Community Ambulatory Practices

    October 22, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Terri R. Fried, MD Section Chief, Geriatrics Professor of Medicine Yale School of Medicine Attending Physician VA Connecticut Healthcare System Topic: The STAMP Trial: Increasing Engagement in Advance Care […]

  • Fri 29

    Grand Rounds October 29: Embedding Pragmatic Trials into Emergency and Critical Care

    October 29, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Matthew W. Semler, MD, MSc Assistant Professor Vanderbilt University Medical Center Jonathan D. Casey, MD, MSc Assistant Professor Vanderbilt University Medical Center Topic: Embedding Pragmatic Trials into Emergency and […]

  • November 2021

  • Fri 5

    Grand Rounds November 5: Benefits of Stroke Treatment Delivered Using a Mobile Stroke Unit Compared to Standard Management by Emergency Medical Services: The BEST-MSU Study

    November 5, 2021 @ 1:00 pm - 2:00 pm

    Speaker: James C Grotta, MD Director Stroke Research and Mobile Stroke Unit Memorial Hermann Hospital-Texas Medical Center Houston, Texas Topic: Benefits of Stroke Treatment Delivered Using a Mobile Stroke Unit Compared to Standard Management by Emergency Medical Services: The BEST-MSU Study Date: Friday, November 5, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you […]

  • Fri 12

    Grand Rounds November 12: Using Financial Incentives to Increase COVID-19 Vaccine Uptake

    November 12, 2021 @ 1:00 pm - 2:00 pm

    Speakers: Charlene Wong, MD MSHP Associate Professor of Pediatrics and Public Policy Duke University School of Medicine Chief Health Policy Officer for COVID-19 North Carolina Department of Health and Human Services   Noel T. Brewer, PhD Gillings Distinguished Professor in Public Health Department of Health Behavior Gillings School of Global Public Health University of North […]

  • Fri 19

    Grand Rounds November 19: Exploring Approaches in Using Digital and Mobile Health in Patient-oriented Research: Pearls and Pitfalls

    November 19, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Anish K. Agarwal MD, MPH MS Assistant Professor of Emergency Medicine Clinical Innovation Manager, Penn Medicine Center for Health Care Innovation University of Pennsylvania, Perelman School of Medicine Topic: Exploring Approaches in Using Digital and Mobile Health in Patient-oriented Research: Pearls and Pitfalls Date: Friday, November 19, 2021, 1:00-2:00 p.m. ET Meeting Info: To […]

  • Fri 26

    Grand Rounds November 26: No Presentation (Thanksgiving Holiday)

    November 26, 2021 @ 1:00 pm - 2:00 pm
  • December 2021

  • Fri 3

    Grand Rounds December 3: Primary Care-Based Behavioral Treatment for Long Term Opioid Users with Chronic Pain: Primary Results and Lessons Learned from the PPACT Pragmatic Trial

    December 3, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Lynn DeBar, PhD MPH Senior Scientist Kaiser Permanente Washington Health Research Institute Seattle, WA Topic: Primary Care-Based Behavioral Treatment for Long Term Opioid Users with Chronic Pain: Primary Results and Lessons Learned from the PPACT Pragmatic Trial Date: Friday, December 3, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate […]

  • Fri 10

    Grand Round December 10: Decentralized Trials: Naughty or Nice?

    December 10, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Adrian F. Hernandez, MD, MHS Executive Director, Duke Clinical Research Institute Vice Dean, Duke University School of Medicine Topic: Decentralized Trials: Naughty or Nice? Date: Friday, December 10, 2021, 1:00-2:00 p.m. ET Meeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files, go to https://dukemed.webex.com/dukemed/systemdiagnosis.php. […]

  • Fri 17

    Grand Rounds December 17: Cyberthreat, Cybersecurity and Cyber Compliance in Clinical Research and Healthcare: One Size Fits None

    December 17, 2021 @ 1:00 pm - 2:00 pm

    Speaker: Eric Perakslis PhD Chief Science & Digital Officer Duke Clinical Research Institute Professor Department of Population Health Sciences Chief Research Technology Strategist Duke University School of Medicine Topic: Cyberthreat, Cybersecurity and Cyber Compliance in Clinical Research and Healthcare: One Size Fits None Date: Friday, December 17, 2021, 1:00-2:00 p.m. ET Meeting Info: To check […]

  • Fri 24

    Grand Rounds December 24: No Presentation (Holiday Break)

    December 24, 2021 @ 1:00 pm - 2:00 pm
  • Fri 31

    Grand Rounds December 31: No Presentation (Holiday Break)

    December 31, 2021 @ 1:00 pm - 2:00 pm
  • January 2022

  • Fri 7

    Grand Rounds January 7: D-PRESCRIBE-AD: A Pragmatic Trial to Educate and Sensitize Caregivers and Healthcare Providers to Reduce Inappropriate Prescription Burden in Persons Living with Dementia

    January 7, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Jerry H. Gurwitz, MD Chief, Division of Geriatric Medicine University of Massachusetts Medical School and UMass Memorial Medical Center Executive Director, Meyers Health Care Institute A joint endeavor of University of Massachusetts Medical School, Fallon Health, and Reliant Medical Group Richard Platt, M.D., M.Sc. President, Harvard Pilgrim Health Care Institute Topic: D-PRESCRIBE-AD: A Pragmatic […]

  • Fri 14

    Grand Rounds January 14: Searching for a Unicorn: Understanding Stakeholder Perspectives When Selecting Outcomes for Outpatient Trials

    January 14, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Christopher Lindsell, PhD Professor of Biostatistics and Biomedical Informatics Director, Vanderbilt Institute for Clinical and Translational Research (VICTR) Methods Program Codirector, Vanderbilt Health Data Science (HEADS) Center Topic: Searching […]

  • Fri 21

    Grand Rounds January 21: Primary Palliative Care for Emergency Medicine

    January 21, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Corita R. Grudzen, MD, MSHS, FACEP Professor, Emergency Medicine and Population Health Associate Dean, Clinical Sciences Deputy Director, Clinical and Translational Science Institute Vice Chair for Research, Emergency Medicine […]

  • Fri 28

    Grand Rounds January 28: EMBED Trial Results: Pragmatic Trial of User-Centered Clinical Decision Support to Implement Emergency Department-Initiated Buprenorphine for Opioid Use Disorder

    January 28, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Edward R Melnick, MD, MHS Associate Professor of Emergency Medicine, Yale School of Medicine Associate Professor of Biostatistics (Health Informatics), Yale School of Public Health Program Director, Yale-VA Clinical […]

  • February 2022

  • Fri 4

    Grand Rounds February 4: SPIRRIT-HFpEF: Opportunities and Challenges in a Large Registry-Based Randomized Clinical Trial

    February 4, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Adam DeVore, MD, MHS Associate Professor of Medicine Duke University Medical Center Duke Clinical Research Institute Lars Lund, MD, PhD Professor of Cardiology Karolinska Institutet Karolinska University Hospital Topic: […]

  • Fri 11

    Grand Rounds February 11: Great Power and Great Responsibility: Machine Learning in Clinical Research(E. Hope Weissler, MD, MHS; Erich Huang, MD, PhD)

    February 11, 2022 @ 1:00 pm - 2:00 pm

    Speakers: E. Hope Weissler, MD, MHS Resident, Vascular and Endovascular Surgery Duke University School of Medicine Erich Huang, MD, PhD Chief Science and Innovation Officer, Onduo Topic: Great Power and […]

  • Fri 18

    Grand Rounds February 18: Building a Resource: The Process of Developing a Trans-stakeholder Framework to Enable Pediatric Drug Development(Perdita Taylor-Zapata, MD)

    February 18, 2022 @ 1:00 pm - 2:00 pm

    Speaker: Perdita Taylor-Zapata, MD Best Pharmaceuticals for Children Act (BPCA) Program Lead and NICHD Program Officer Obstetric and Pediatric Pharmacology and Therapeutics Branch National Institute of Child Health and Human […]

  • Fri 25

    Grand Rounds February 25: The Next Generation of Patient-Centered Trials – No Site Visits, Home-delivery of Meds and Patient-reported Outcomes – The CHIEF-HF Trial(John Spertus MD MPH FACC FAHA)

    February 25, 2022 @ 1:00 pm - 2:00 pm

    Speaker: John Spertus, MD MPH FACC FAHA Daniel Lauer/Missouri Endowed Chair and Professor University of Missouri – Kansas City Clinical Director of Outcomes Research Saint Luke’s Mid America Heart Institute […]

  • March 2022

  • Fri 4

    Grand Rounds March 4: ACP COVID: A Trial to Evaluate an Advance Care Planning Video and Communication Skills Training Intervention for Older Adults During an Evolving Pandemic (Angelo E. Volandes, MD, MPH; James A. Tulsky, MD; Sophia N. Zupanc, BA)

    March 4, 2022 @ 1:00 pm - 2:00 pm

    Speakers: Angelo E. Volandes, MD, MPH Associate Professor, Harvard Medical School and Massachusetts General Hospital James A. Tulsky, MD Chair, Department of Psychosocial Oncology and Palliative Care Dana-Farber Cancer Institute […]

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