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Living Textbook of
Pragmatic Clinical Trials

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Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
13 events found.

Events

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  • November 2025

  • Fri 14

    Grand Rounds November 14, 2025: IMPACT-BP: A Community-Based Intervention for Sustainable Blood Pressure Control in Rural KwaZulu-Natal, South Africa (Mark Siedner, MD, MPH)

    November 14, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Mark Siedner, MD, MPH Professor of Medicine, Harvard Medical School Faculty, Africa Health Research Institute Title: IMPACT-BP: A Community-Based Intervention for Sustainable Blood Pressure Control in Rural KwaZulu-Natal, South […]

  • Fri 21

    Grand Rounds November 21, 2025: Insights Informing Strategies for Optimizing the Collection of Clinical Trial Data (Laura Galuchie, BS; Zak Smith, MA)

    November 21, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Laura Galuchie, BS Senior Director, Global Clinical Development Merck & Co, Inc. Zak Smith, MA Assistant Director, Data Sciences & Analytics Tufts Center for the Study of Drug Development […]

  • December 2025

  • Fri 5

    Grand Rounds December 5, 2025: Transcutaneous Electrical Nerve Stimulation Reduces Movement-Pain in People With Fibromyalgia: Results From FM-TIPS, a Cluster Randomized Pragmatic Trial (Leslie J. Crofford, MD; Dana Dailey, PT, PhD; Kathleen Sluka, PT, PhD, FAPTA)

    December 5, 2025 @ 1:00 am - 2:00 pm

    Speakers: Leslie J. Crofford, MD Wilson Family Chair in Medicine Professor of Medicine and Pathology, Microbiology & Immunology Vanderbilt University Medical Center Dana Dailey PT, PhD Assistant Research Scientist Physical […]

  • Fri 12

    Grand Rounds December 12, 2025: From Eligibility to Enrollment Without a Clinic Visit: The Eat Well Produce Prescription Trial for Patients with Diabetes at Risk of Food Insecurity (Connor Drake, PhD, MPA; Susan Spratt, MD)

    December 12, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Connor Drake, PhD, MPA Research Health Scientist Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT) Durham VA Health System HSR&D Assistant Professor Department of Population Health Sciences […]

  • Fri 19

    Grand Rounds December 19, 2025: Use of Ambient AI Scribes to Reduce Administrative Burden and Professional Burnout: Lessons Learned and Future Directions (Lee H. Schwamm, MD; Kristine Olson, MD, MSc; Daniella Meeker, PhD)

    December 19, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Lee H. Schwamm, MD Sr Vice President and Chief Digital Health Officer Yale New Haven Health System Associate Dean, Digital Strategy & Transformation Professor of Neurology and of Biomedical […]

  • January 2026

  • Fri 9

    Grand Rounds January 9, 2026: Pragmatic Care Embedded Randomization: Insights From the KP-VACCINATE Megatrial (Ankeet S. Bhatt, MD, MBA, ScM)

    January 9 @ 1:00 pm - 2:00 pm

    Speaker: Ankeet S. Bhatt, MD, MBA, ScM Cardiologist, Kaiser Permanente San Francisco Medical Center Research Scientist, Kaiser Permanente Northern California Division of Research Assistant Professor, Kaiser Permanente Bernard J. Tyson […]

  • Fri 16

    Grand Rounds January 16, 2026: Can Financial Incentives Increase Participation in a Memory Concerns Registry? (Mireille Jacobson, PhD)

    January 16 @ 1:00 pm - 2:00 pm

    Speaker: Mireille Jacobson, PhD Professor, University of Southern California Davis School of Gerontology and Schaeffer Institute Title: Can Financial Incentives Increase Participation in a Memory Concerns Registry? Date: Friday, January […]

  • Fri 23

    Grand Rounds January 23, 2026: DASH Groceries to Stop Hypertension: Results From the GoFresh Trial (Stephen P. Juraschek, MD, PhD, FAHA, AHSCP-CHS)

    January 23 @ 1:00 pm - 2:00 pm

    Speaker: Stephen P. Juraschek, MD, PhD, FAHA, AHSCP-CHS Associate Professor of Medicine HCA Hypertension Center Director & Beth Israel Deaconess Medical Center Title: DASH Groceries to Stop Hypertension: Results From […]

  • Fri 30

    Grand Rounds January 30, 2026: A Pragmatic Randomized Controlled Trial of Ambient Artificial Intelligence to Improve Health Practitioner Well-Being (Majid Afshar, MD, MS; Mary Ryan Baumann, PhD)

    January 30 @ 1:00 pm - 2:00 pm

    Speakers: Majid Afshar, MD, MS Associate Professor Director, Learning Health Systems Departments of Medicine and Biostatistics & Medical Informatics University of Wisconsin-Madison Mary Ryan Baumann, PhD Assistant Professor Departments of […]

  • February 2026

  • Fri 6

    Grand Rounds February 6, 2026: Spinal Manipulation and Clinician-Supported Biopsychosocial Self-Management for Acute Back Pain: The PACBACK Randomized Clinical Trial (Gert Bronfort, DC, PhD; Brent Leininger, DC, MS, PhD)

    February 6 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/98476157601?pwd=a2wr77PsUjnSUnlvCWZTp5Fgq85VoF.1 Passcode: 078960 Title: Spinal Manipulation and Clinician-Supported Biopsychosocial Self-Management for Acute Back Pain: The PACBACK Randomized Clinical Trial Speakers: Gert Bronfort, DC, PhD Research Professor Integrative […]

  • Fri 13

    Grand Rounds February 13, 2026: The Making of the PCORnet® COMPARE-Pediatric IBD Study (Michael D. Kappelman, MD, MPH)

    February 13 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/98504893560?pwd=eezPa5qorRupc7WnKHNQw24bjiicve.1 Passcode: 748803 Title: The Making of the PCORnet® COMPARE-Pediatric IBD Study Speaker: Michael D. Kappelman, MD, MPH Professor, Pediatric Gastroenterology University of North Carolina at Chapel […]

  • Fri 20

    Grand Rounds February 20, 2026: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention (RAMP): Early Progress and Lessons Learned (Diana Burgess, PhD; Roni Evans, DC, MS, PhD; Katie Hadlandsmyth, PhD)

    February 20 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/93501751057?pwd=Jha0pVbt6nNlTFw4wm2h6jei784VWV.1 Passcode: 691159 Title: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention (RAMP): Early Progress and Lessons Learned Speakers: Diana Burgess, PhD Professor of […]

  • Fri 27

    Grand Rounds February 27, 2026: Optimal Transfusion Strategy in High Cardiac Risk Patients After Major Surgery: Results of the TOP Trial (Panos Kougias, MD, MSc; Sherene Sharath, PhD, MPH)

    February 27 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/99531269455?pwd=KhlCK19gGyh1AM1lNpwaO8ZU4SBXlq.1 Passcode: 629631 Title: Optimal Transfusion Strategy in High Cardiac Risk Patients After Major Surgery: Results of the TOP Trial Speakers: Panos Kougias, MD, MSc Professor and […]

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