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Living Textbook of
Pragmatic Clinical Trials

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Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
11 events found.

Events

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  • February 2026

  • Fri 6

    Grand Rounds February 6, 2026: Spinal Manipulation and Clinician-Supported Biopsychosocial Self-Management for Acute Back Pain: The PACBACK Randomized Clinical Trial (Gert Bronfort, DC, PhD; Brent Leininger, DC, MS, PhD)

    February 6 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/98476157601?pwd=a2wr77PsUjnSUnlvCWZTp5Fgq85VoF.1 Passcode: 078960 Title: Spinal Manipulation and Clinician-Supported Biopsychosocial Self-Management for Acute Back Pain: The PACBACK Randomized Clinical Trial Speakers: Gert Bronfort, DC, PhD Research Professor Integrative […]

  • Fri 13

    Grand Rounds February 13, 2026: The Making of the PCORnet® COMPARE-Pediatric IBD Study (Michael D. Kappelman, MD, MPH)

    February 13 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/98504893560?pwd=eezPa5qorRupc7WnKHNQw24bjiicve.1 Passcode: 748803 Title: The Making of the PCORnet® COMPARE-Pediatric IBD Study Speaker: Michael D. Kappelman, MD, MPH Professor, Pediatric Gastroenterology University of North Carolina at Chapel […]

  • Fri 20

    Grand Rounds February 20, 2026: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention (RAMP): Early Progress and Lessons Learned (Diana Burgess, PhD; Roni Evans, DC, MS, PhD; Katie Hadlandsmyth, PhD)

    February 20 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/93501751057?pwd=Jha0pVbt6nNlTFw4wm2h6jei784VWV.1 Passcode: 691159 Title: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention (RAMP): Early Progress and Lessons Learned Speakers: Diana Burgess, PhD Professor of […]

  • Fri 27

    Grand Rounds February 27, 2026: Optimal Transfusion Strategy in High Cardiac Risk Patients After Major Surgery: Results of the TOP Trial (Panos Kougias, MD, MSc; Sherene Sharath, PhD, MPH)

    February 27 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/99531269455?pwd=KhlCK19gGyh1AM1lNpwaO8ZU4SBXlq.1 Passcode: 629631 Title: Optimal Transfusion Strategy in High Cardiac Risk Patients After Major Surgery: Results of the TOP Trial Speakers: Panos Kougias, MD, MSc Professor and […]

  • March 2026

  • Fri 6

    Grand Rounds March 6, 2026: Bringing Primary Care Clinical Trials Research Into the 21st Century: Lessons Learned and Developments From Large-Scale European Adaptive Platform Trials of Therapeutics for Acute Respiratory Infections (Christopher C. Butler, BA, MBChB, DCH, CCH, MD, FRCGP)

    March 6 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/94319236794?pwd=dlbIVzOxEnLnj5MG6gsd9bxPv4fE2s.1 Passcode: 319575 Title: Bringing Primary Care Clinical Trials Research Into the 21st Century: Lessons Learned and Developments From Large-Scale European Adaptive Platform Trials of Therapeutics for […]

  • Fri 13

    Grand Rounds March 13, 2026: Behavioral Economics and Medication Adherence for Hypertension: A Randomized Clinical Trial (John A. Dodson, MD, MPH)

    March 13 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/98174419562?pwd=N3fF3KQMBbvQNx58w0u3GJpEYY6bPI.1 Passcode: 371666 Title: Behavioral Economics and Medication Adherence for Hypertension: A Randomized Clinical Trial Speaker: John A. Dodson, MD, MPH Associate Professor of Medicine and Population […]

  • Fri 20

    Grand Rounds March 20, 2026: FLUID: A Cross-Over Trial of Hospital Wide Ringer’s Lactate vs Normal Saline (Lauralyn McIntyre, MD, FRCPC, MSc; Monica Taljaard, PhD)

    March 20 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/99552474559?pwd=FRcC8BqOgDLKwOnP7p3k1TeqOG3tuG.1 Passcode: 034815 Title: FLUID: A Cross-Over Trial of Hospital Wide Ringer’s Lactate vs Normal Saline Speakers: Lauralyn McIntyre, MD, FRCPC, MSc Senior Scientist, Acute Care Research […]

  • Fri 27

    Grand Rounds March 27, 2026: Text Messaging and Video Stories to Support Hypertension Self-Management in Black Veterans: A Randomized Clinical Trial (Sarah L. Cutrona, MD, MPH)

    March 27 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/98879362324?pwd=qYsmTt9OEyFG3EaL019QgsLVq3sYDn.1 Passcode: 436216 Title: Text Messaging and Video Stories to Support Hypertension Self-Management in Black Veterans: A Randomized Clinical Trial Speaker: Sarah L. Cutrona, MD, MPH Acting […]

  • April 2026

  • Fri 3

    Grand Rounds April 3, 2026: AI for Diabetes Prevention (Nestoras Mathioudakis, MD, MHS)

    April 3 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/95834413725?pwd=8rFVl3scmBRUabiz2JCrr5g1aIdIQH.1 Passcode: 457732 Title: AI for Diabetes Prevention Speaker: Nestoras Mathioudakis, MD, MHS Associate Professor of Medicine Johns Hopkins University School of Medicine Date: Friday, April 3, […]

  • Fri 10

    Grand Rounds April 10, 2026: Impact of Behavioral Science-Based Electronic Health Record Tools on Deprescribing for Older Adults (Julie Lauffenburger, PharmD, PhD)

    April 10 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/95737711530?pwd=WDHDhfijWQA58qgyegJEIPY3HmNmSv.1 Passcode: 931340 Title: Impact of Behavioral Science-Based Electronic Health Record Tools on Deprescribing for Older Adults Speaker: Julie Lauffenburger, PharmD, PhD Associate Professor of Medicine Brigham […]

  • Fri 17

    Grand Rounds April 17, 2026: Keeping a Human in the Loop: Scientific Publishing and AI (Roy Perlis, MD, MSc)

    April 17 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/93579352332?pwd=PHTSdxudlxVfFxztMNM3CwUb0Miykb.1 Passcode: 827623 Title: Keeping a Human in the Loop: Scientific Publishing and AI Speaker: Roy Perlis, MD MSc Editor in Chief, JAMA+ AI Director, MGH Center […]

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