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Living Textbook of
Pragmatic Clinical Trials

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Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
11 events found.

Events

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  • October 2025

  • Fri 10

    Grand Rounds October 10, 2025: Engaging Rural Communities in Pragmatic Clinical Trials: Leveraging the CARE for Health Initiative Hubs to Enhance Enrollment for BeatPain (Julie M. Fritz, PhD, PT, FAPTA; Sebastian Tong, MD, MPH)

    October 10, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Julie M. Fritz, PhD, PT, FAPTA Distinguished Professor Department of Physical Therapy & Athletic Training University of Utah Sebastian Tong, MD, MPH Associate Professor University of Washington Title: Engaging Rural Communities in Pragmatic Clinical Trials: Leveraging the CARE for Health Initiative Hubs to Enhance Enrollment for BeatPain Date: Friday, October 10, 2025, 1:00-2:00 p.m. […]

  • Fri 17

    Grand Rounds October 17, 2025: Making Effective Use of Data Infrastructure in PCORnet® (Charles Bailey, MD, PhD; Keith Marsolo, PhD)

    October 17, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Charles Bailey, MD, PhD Department of Pediatrics Perelman School of Medicine University of Pennsylvania Biomedical and Health Informatics Children’s Hospital of Philadelphia Keith Marsolo, PhD Associate Professor Department of Population Health Sciences Duke Clinical Research Institute Duke University School of Medicine Title: Making Effective Use of Data Infrastructure in PCORnet® Date: Friday, October 17, […]

  • Fri 24

    Grand Rounds October 24, 2025: Studying Neglected Diseases: Insights from the PARACHUTE-HF Trial (Renato Lopes MD, PhD)

    October 24, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Renato Lopes MD, PhD Professor of Medicine, Division of Cardiology Duke University Medical Center Duke Clinical Research Institute Title: Studying Neglected Diseases: Insights from the PARACHUTE-HF Trial Date: Friday, October 24, 2025, 1:00-2:00 p.m. ET Please click the link below to join the webinar: https://duke.zoom.us/j/95426638742?pwd=Tz702ByfCbfa3EDhUaajOpbsshq6xp.1 Passcode: 044731 One-Tap Mobile +16468769923,,95426638742#,,,,*044731# +16469313860,,95426638742#,,,,*044731# Audio Only Option […]

  • Fri 31

    Grand Rounds October 31, 2025: The LHS Shared Commitments — All Treats, No Tricks (Peter Margolis, MD, PhD; Sean C. Dowdy, MD, FACS, FACOG; Sarah Greene, MPH)

    October 31, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Peter Margolis, MD, PhD Adjunct Professor of Pediatrics Stanford University School of Medicine Emeritus Professor of Pediatrics University of Cincinnati School of Medicine Former Co-Director of the James M. […]

  • November 2025

  • Fri 7

    Grand Rounds November 7, 2025: EMMA – A Remote, Decentralized Clinical Trial to Evaluate the Effectiveness of a Migraine App (Daniel Pach, MD; Stefanie Lysk, MS)

    November 7, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Daniel Pach, MD Charité – Universitätsmedizin Berlin Stefanie Lysk, MS Charité – Universitätsmedizin Berlin Newsenselab GmbH (app manufacturer) Title: EMMA – A Remote, Decentralized Clinical Trial to Evaluate the […]

  • Fri 14

    Grand Rounds November 14, 2025: IMPACT-BP: A Community-Based Intervention for Sustainable Blood Pressure Control in Rural KwaZulu-Natal, South Africa (Mark Siedner, MD, MPH)

    November 14, 2025 @ 1:00 pm - 2:00 pm

    Speaker: Mark Siedner, MD, MPH Professor of Medicine, Harvard Medical School Faculty, Africa Health Research Institute Title: IMPACT-BP: A Community-Based Intervention for Sustainable Blood Pressure Control in Rural KwaZulu-Natal, South […]

  • Fri 21

    Grand Rounds November 21, 2025: Insights Informing Strategies for Optimizing the Collection of Clinical Trial Data (Laura Galuchie, BS; Zak Smith, MA)

    November 21, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Laura Galuchie, BS Senior Director, Global Clinical Development Merck & Co, Inc. Zak Smith, MA Assistant Director, Data Sciences & Analytics Tufts Center for the Study of Drug Development […]

  • December 2025

  • Fri 5

    Grand Rounds December 5, 2025: Transcutaneous Electrical Nerve Stimulation Reduces Movement-Pain in People With Fibromyalgia: Results From FM-TIPS, a Cluster Randomized Pragmatic Trial (Leslie J. Crofford, MD; Dana Dailey, PT, PhD; Kathleen Sluka, PT, PhD, FAPTA)

    December 5, 2025 @ 1:00 am - 2:00 pm

    Speakers: Leslie J. Crofford, MD Wilson Family Chair in Medicine Professor of Medicine and Pathology, Microbiology & Immunology Vanderbilt University Medical Center Dana Dailey PT, PhD Assistant Research Scientist Physical […]

  • Fri 12

    Grand Rounds December 12, 2025: From Eligibility to Enrollment Without a Clinic Visit: The Eat Well Produce Prescription Trial for Patients with Diabetes at Risk of Food Insecurity (Connor Drake, PhD, MPA; Susan Spratt, MD)

    December 12, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Connor Drake, PhD, MPA Research Health Scientist Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT) Durham VA Health System HSR&D Assistant Professor Department of Population Health Sciences […]

  • Fri 19

    Grand Rounds December 19, 2025: Use of Ambient AI Scribes to Reduce Administrative Burden and Professional Burnout: Lessons Learned and Future Directions (Lee H. Schwamm, MD; Kristine Olson, MD, MSc; Daniella Meeker, PhD)

    December 19, 2025 @ 1:00 pm - 2:00 pm

    Speakers: Lee H. Schwamm, MD Sr Vice President and Chief Digital Health Officer Yale New Haven Health System Associate Dean, Digital Strategy & Transformation Professor of Neurology and of Biomedical […]

  • January 2026

  • Fri 9

    Grand Rounds January 9, 2026: Pragmatic Care Embedded Randomization: Insights From the KP-VACCINATE Megatrial (Ankeet S. Bhatt, MD, MBA, ScM)

    January 9 @ 1:00 pm - 2:00 pm

    Speaker: Ankeet S. Bhatt, MD, MBA, ScM Cardiologist, Kaiser Permanente San Francisco Medical Center Research Scientist, Kaiser Permanente Northern California Division of Research Assistant Professor, Kaiser Permanente Bernard J. Tyson […]

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