Grand Rounds Series: Advances in the Design and Analysis of Pragmatic Clinical Trials

In 2023, the NIH Pragmatic Trials Collaboratory held a special Grand Rounds series to share advances in the design and analysis of pragmatic clinical trials. The presentations shared the latest best practices and explored emerging questions with experts from the program’s Biostatistics and Study Design Core.

Throughout the program's history, the Core has worked with investigators to fine-tune study designs, develop rigorous analysis plans, and offer guidance to the broader community of researchers who are planning pragmatic trials. With this Grand Rounds series, the Core brought together biostatisticians, clinical trials methodologists, and investigators to discuss challenges and share lessons learned in the design, implementation, and analysis of pragmatic trials. Sessions focused on a range of topics, including complex clustering, best practices in the design and analysis of stepped-wedge trials, and handling missing data in cluster randomized trials.

Access the recordings:

• October 6, 2023: Hybrid Studies Should Not Sacrifice Rigorous Methods 
  Speaker: David M. Murray, PhD
  Moderator: Jonathan Moyer, PhD
• November 3, 2023: The Perils and Pitfalls of Complex Clustering in Pragmatic Trials
  Speaker: Jonathan Moyer, PhD
  Moderator: Andrea Cook, PhD
• December 1, 2023: Guidelines for Design and Analysis of Stepped-Wedge Trials
  Speaker: Jim Hughes, PhD
  Moderator: Patrick Heagerty, PhD
• January 5, 2023: Methods for Handling Missing Data in Cluster Randomized Trials
  Speaker: Rui Wang, PhD
  Moderator: Fan Li, PhD