Skip to content

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
  • Home
  • About
    • NIH Collaboratory
      • Coordinating Center
      • NIH Collaboratory Trials
      • Core Working Groups
      • Steering Committee
      • Distributed Research Network
      • Our Impact
    • Living Textbook
      • Table of Contents
      • How to Use This Site
  • Resources
    • Data and Resource Sharing
    • Training Resources
    • Tools for Researchers
    • Publications
    • Knowledge Repository
  • Webinar
  • Podcast
  • News
    • News Feed
    • Calendar
    • Subscribe
return to home
Subscribe to Newsletter go to twitter feed go to linkedin go to blue sky feed
Search
NIH Collaboratory
Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
home button

Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Mobile Health
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures

Disseminating and Sharing CDS

CHAPTER SECTIONS

Real World Evidence: Clinical Decision Support


Section 6

Disseminating and Sharing CDS

Expand Contributors

Brian Douthit, MSN
Rachel Richesson, PhD, MPH
Keith Marsolo, PhD
Edward R. Melnick, MD, MHS
Corita R. Grudzen, MD
Lesley Curtis, PhD

Contributing Editor
Karen Staman, MS

Vision of the NIH Collaboratory

The goal of the NIH Collaboratory is to build a national infrastructure to support PCTs, including trials with positive results that can be adopted by any organization, regardless of size. When CDS is part of the intervention, it needs to be presented in a way to be easily adopted to local organizations. Researchers should include plans to share their CDS-based interventions; some options are outlined below.

Why and When to Disseminate

Data and resource sharing is fundamental to the mission of the NIH Collaboratory, and sharing details about CDS tools used in the NIH Collaboratory Trials is consistent with that.  Pragmatic trialists should plan to share details about effective CDS tools in order to disseminate their interventions beyond their organizations. This can be done through many media, including through publications and conferences. In addition to more established academic media, publishing the CDS tool itself can save potential implementers months of work and costs for local adoption, and this should be considered the gold standard of dissemination.

AHRQ has developed CDS Connect as a repository for CDS artifacts that identify and codify new evidence-based standards of care. Another such hosting platform is the SMART (Substitutable Medical Applications, Reusable Technologies) App Gallery, where different apps are hosted for use on the web, via smartphones, or the EHR. OpenCDS is a similar resource, where standards-based open source CDS tools are hosted. Both may require some work on the part of the adopting institution, as FHIR or certain terminology standards may differ from what is done locally, so extra work in mapping may be necessary. EHR vendors also maintain ways of sharing artifacts with and between their customers, and while this in not open source, it provides another mechanism for disseminating CDS tools.

Previous Section Next Section

SECTIONS

CHAPTER SECTIONS

sections

  1. Introduction
  2. Definitions and Uses
  3. Uses in PCTs: Experiences From the NIH Collaboratory Trials
  4. Designing and Building CDS Tools for Pragmatic Clinical Trials
  5. Evaluating CDS
  6. Disseminating and Sharing CDS
  7. Additional Resources

Resources

AHRQ CDS Initiatives
AHRQ initiatives that aim to promote evidence in practice through CDS.


Version History

December 3, 2025: Updated hyperlinks (changes made by G. Uhlenbrauck).

July 2, 2020: Minor corrections to layout and formatting (changes made by D. Seils).

Published May 30, 2020

current section :

Disseminating and Sharing CDS

  1. Introduction
  2. Definitions and Uses
  3. Uses in PCTs: Experiences From the NIH Collaboratory Trials
  4. Designing and Building CDS Tools for Pragmatic Clinical Trials
  5. Evaluating CDS
  6. Disseminating and Sharing CDS
  7. Additional Resources

Citation:

Douthit B, Richesson RL, Marsolo K, et al. Real World Evidence: Clinical Decision Support: Disseminating and Sharing CDS. In: Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials. Bethesda, MD: NIH Pragmatic Trials Collaboratory. Available at: https://rethinkingclinicaltrials.org/chapters/conduct/real-world-evidence-clinical-decision-support/cds-and-the-collaboratory/. Updated December 3, 2025. DOI: 10.28929/135.

Footer Menu

  • How to Use This Site
  • About NIH Collaboratory
  • Enrollment Reporting
  • Grand Rounds
  • Funding Statement
Link to Twitter Link to LinkedIn Link to Blue Sky Link to NIH Collaboratory email

Reference in this Web site to any specific commercial products, process, service, manufacturer, or company does not constitute its endorsement or recommendation by the U.S. Government or National Institutes of Health (NIH). NIH is not responsible for the contents of any “off-site” Web page referenced from this server.

Log in
Privacy Statement
WordPress is a content management system and should not be used to upload any PHI as it is not an environment for which we exercise oversight, meaning you the author are responsible for the content you post. Please use this system accordingly. Site Map