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Living Textbook of
Pragmatic Clinical Trials

COVID-19 Resources

Access the latest information on COVID-19 for clinical researchers
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Rethinking Clinical Trials

A Living Textbook of Pragmatic Clinical Trials

  • Design
    • What is a Pragmatic Clinical Trial?
    • Decentralized Pragmatic Clinical Trials
    • Developing a Compelling Grant Application
    • Experimental Designs and Randomization Schemes
    • Endpoints and Outcomes
    • Analysis Plan
    • Using Electronic Health Record Data
    • Building Partnerships and Teams to Ensure a Successful Trial
    • Intervention Delivery and Complexity
    • Patient Engagement
  • Data, Tools & Conduct
    • Assessing Feasibility
    • Acquiring Real-World Data
    • Assessing Fitness-for-Use of Real-World Data
    • Study Startup
    • Participant Recruitment
    • Monitoring Intervention Fidelity and Adaptations
    • Patient-Reported Outcomes
    • Clinical Decision Support
    • Electronic Health Records–Based Phenotyping
    • Navigating the Unknown
  • Interpretation, Dissemination & Implementation
    • Data Sharing and Embedded Research
    • Collaborating With Health System Partners to Review and Understand Trial Results
    • Dissemination Approaches for Different Audiences
    • Implementation
    • End-of-Trial Decision-Making
  • Ethics & Regulatory
    • Privacy Considerations
    • Identifying Those Engaged in Research
    • Collateral Findings
    • Consent, Disclosure, and Non-Disclosure
    • Data and Safety Monitoring
    • Ethical Considerations of Data Sharing in Pragmatic Clinical Trials
    • Ethics for AI and ML
    • IRB Responsibilities and Procedures
10 events found.

Events

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  • May 2026

  • Fri 15

    Grand Rounds May 15, 2026: The Importance of Choosing the Right Outcomes: How to Improve Interpretability of Randomized Trials (Anup Katheria, MD)

    May 15 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/99186302333?pwd=2fbXZUQDr81CKD45LHuzna5a2JtpqR.1 Passcode: 638865 Title: The Importance of Choosing the Right Outcomes: How to Improve Interpretability of Randomized Trials Speaker: Anup Katheria, MD Director of the Neonatal Research […]

  • Fri 29

    Grand Rounds May 29, 2026: Mobile Telemedicine for Treating Chronic Hepatitis C Among Rural People Who Inject Drugs: A Randomized Clinical Trial (Thomas J. Stopka, PhD, MHS)

    May 29 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/98190587674?pwd=DGSNhyiyrUIn0FOzWWiEnur9scp55t.1 Passcode: 572896 Title: Mobile Telemedicine for Treating Chronic Hepatitis C Among Rural People Who Inject Drugs: A Randomized Clinical Trial Speaker: Thomas J. Stopka, PhD, MHS […]

  • June 2026

  • Fri 5

    Grand Rounds June 5, 2026: Bringing Context and Clarity to Clinical Trial Research for Clinician and Public Health Audiences: JAMA+ Trials (Alison Huang, MD, MAS; Derek Angus, MD, MPH)

    June 5 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/91096841933?pwd=DbYMdQoU0oSWCwGXXrr6MYbPb7QHsb.1 Passcode: 727212 Title: Bringing Context and Clarity to Clinical Trial Research for Clinician and Public Health Audiences: JAMA+ Trials Speakers: Alison Huang, MD, MAS Editor-in-Chief of […]

  • Fri 12

    Grand Rounds June 12, 2026: The REVIVE-TOGETHER Trial: Findings From an Evaluation of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID (Jamie Forrest, PhD, MPH)

    June 12 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/95622250352?pwd=f2agJtS25deVbuPaqtTLiaPueQvi1A.1 Passcode: 557121 Title: The REVIVE-TOGETHER Trial: Findings From an Evaluation of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID Speaker: Jamie Forrest, PhD, MPH […]

  • Fri 26

    Grand Rounds June 26, 2026: Precision Engagement to Improve Population Health (Phillip D. Levy, MD, MPH)

    June 26 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/92966966418?pwd=1rhNFKp1XUbfoO6QalwNnB1Xk7WE7v.1 Passcode: 067559 Title: Precision Engagement to Improve Population Health Speaker: Phillip D. Levy, MD, MPH Professor of Emergency Medicine and Physiology Associate Vice President for Population […]

  • July 2026

  • Fri 10

    Grand Rounds July 10, 2026: A Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (Fran Balamuth, MD, PhD, MSCE; Scott L. Weiss, MD, MSCE)

    July 10 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/94892456308?pwd=H0Bov0uOsi2XeG5MRPp2e57r1ATMnl.1 Passcode: 079606 Title: A Pragmatic Pediatric Trial of Balanced versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS) Speakers: Fran Balamuth, MD, PhD, MSCE Division Chief, Emergency […]

  • Fri 17

    Grand Rounds July 17, 2026: Sodium Bicarbonate for Metabolic Acidosis in the Intensive Care Unit (Ary Serpa Neto, MD, MSc, PhD, FCICM)

    July 17 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/94233820007?pwd=KWJoaycVdhf9sFUT5GF03YaD48rMve.1 Passcode: 058750 Title: Sodium Bicarbonate for Metabolic Acidosis in the Intensive Care Unit (SODa-BIC Trial) Speaker: Ary Serpa Neto, MD, MSc, PhD, FCICM Associate Professor Co-Deputy […]

  • Fri 24

    Grand Rounds July 24, 2026: The Pediatric Trials Network: Innovating to Make Drugs Safe and Effective for Children (Rachel Greenberg, MD, MB, MHS; Danny Benjamin, MD, PhD, MPH)

    July 24 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/97663773340?pwd=2ae7AMJ0dJbCbWpbs9rC97Kbgjx34T.1 Passcode: 090988 Title: The Pediatric Trials Network: Innovating to Make Drugs Safe and Effective for Children Speakers: Rachel Greenberg, MD, MB, MHS Professor of Pediatrics Duke […]

  • Fri 31

    Grand Rounds July 31, 2026: Sequenced Care Pathway Versus Pain Navigator Pathway for Veterans With Low Back Pain: Results and Reflections From the AIM-Back Cluster Randomized Clinical Trial (Steven Z. George, PT, PhD; S. Nicole Hastings, MD, MHS)

    July 31 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/92815438229?pwd=B5W1avAyuCSfwpumvauMlfSqNSsL5c.1 Passcode: 263489 Title: Sequenced Care Pathway Versus Pain Navigator Pathway for Veterans With Low Back Pain: Results and Reflections From the AIM-Back Cluster Randomized Clinical Trial […]

  • August 2026

  • Fri 7

    Grand Rounds August 7, 2026: ADAPT-CEC: AI for Clinical Event Adjudication and Implications for Clinical Trials (Sreek Vemulapalli, MD; Ricardo Henao, PhD)

    August 7 @ 1:00 pm - 2:00 pm

    Join the webinar: https://duke.zoom.us/j/98104394470?pwd=sqW1LXaFl604IucOMHteMUWWwsRoCw.1 Passcode: 784253 Title: ADAPT-CEC: AI for Clinical Event Adjudication and Implications for Clinical Trials Speakers: Sreek Vemulapalli, MD Associate Professor of Medicine with Tenure Director, CV […]

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