In this Friday’s Rethinking Clinical Trials Grand Rounds, Margaret Kuklinski and Stacy Sterling will present their main outcomes in “A Pragmatic Trial of Family-Focused Prevention in Pediatric Primary Care: Successes, Challenges, and Lessons Learned – Guiding Good Choices for Health (GGC4H).” Congratulations to Drs. Kuklinski, Sterling, and the entire GGC4H study team!
The Grand Rounds session will be held on Friday, October 30, 2026, at 1:00 pm eastern.
GGC4H is a cluster-randomized trial that tested the feasibility and effectiveness of implementing Guiding Good Choices—a universal evidence-based anticipatory guidance curriculum for parents of early adolescents—in 3 large, integrated healthcare systems serving socioeconomically diverse families. In prior community trials, the Guiding Good Choices curriculum has been shown to prevent adolescent substance use, depressive symptoms, and delinquent behavior. This study offered an opportunity to test the intervention’s effectiveness with respect to improving adolescent behavioral health outcomes when implemented at scale in pediatric primary care within a pragmatic trial.
Kuklinski is the director of the Social Development Research Group and Center for Communities That Care as well as a professor at the University of Washington. Sterling is a senior scientist and co-director of the Center for Addiction and Mental Health Research at the Kaiser Permanente Division of Research as well as a professor at the Kaiser Permanente Bernard J. Tyson School of Medicine.
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