September 8-9, 2026: This 2-day workshop explored the factors involved in selecting endpoints and interpreting treatment effects in embedded pragmatic clinical trials (ePCTs) to best inform decision-making. A series of panels addressed considerations for selecting endpoints that reliably measure concepts of interest in ePCTs; influential factors in the analysis and interpretation of treatment effects; applications of multicomponent and hierarchical endpoints; and real-world examples of various endpoint strategies in ePCTs.
Agenda, Slides, and Recordings
Day 1: September 8
Welcome and Introduction
Wendy Weber, ND, PhD, MPH
David Shurtleff, PhD
Kevin Weinfurt, PhD
Opening Presentation: Defining the Endpoint: Where Evidence Begins
Kevin Weinfurt, PhD
Session 1: Aiming for Impact: What is the Right Concept to Target?
Moderator: Steven George, PT, PhD, FAPTA
Panel:
- Michael Ho, MD, PhD
- Frederick Masoudi, MD, MSPH, MACC, FAHA
- Miguel Vazquez, MD
- Tracy Wang, MD, MHS, MSc
- Wendy Weber, ND, PhD, MPH
Session 2: The Estimands Framework: Aligning Objectives, Endpoints, and Analyses
Moderator: Liz Turner, PhD
Panel:
- Elizabeth Colantuoni, PhD, ScM
- Fan Li, PhD
- Richard Skolasky, Jr, MA, ScD
- Hulin Wu, PhD
Session 3: Working With Multiple Outcomes: Multicomponent Endpoints and Beyond
Moderator: Emily O’Brien, PhD
Panel:
- Julie Fritz, PhD, PT
- Patrick Heagerty, PhD
- Eric Roseen, DC, PhD
- Pamela Shaw, PhD, MS
- Qilu Yu, PhD
Summary and Concluding Remarks
Steven George, PT, PhD, FAPTA
Emily O’Brien, PhD
Liz Turner, PhD
Kevin Weinfurt, PhD
Day 2: September 9
Welcome and Introduction
Wendy Weber, ND, PhD, MPH
David Shurtleff, PhD
Kevin Weinfurt, PhD
Opening Presentation: Moving From Measurement to Meaning
Kevin Weinfurt, PhD
Session 4: Unpacking Uncertainty, Meaningfulness, and Magnitude
Moderator: Greg Simon, MD, MPH
Panel:
- Devon Check, PhD
- Lynn DeBar, PhD, MPH
- Juan Marcos Gonzalez, PhD
- Laura Lee Johnson, PhD
- Natalia Morone, MD, MS
Session 5: Toward Best Practices for Interpretation of Endpoints
Moderators: Adrian Hernandez, MD, MHS; Kevin Weinfurt, PhD
Panel:
- Andrea Cook, PhD
- Corita Grudzen, MD, MSHS
- Liz Turner, PhD
- Kari Stephens, PhD
- Christy Zigler, PhD, MSEd
Summary and Concluding Remarks
Patrick Heagerty, PhD
Adrian Hernandez, MD, MHS
Greg Simon, MD, MPH
Kevin Weinfurt, PhD