Welcome to the Living Textbook

Welcome to the NIH Collaboratory’s Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials! The Living Textbook is designed to provide information on how to understand, design, conduct, analyze & disseminate pragmatic clinical trials (PCTs).

Rethinking Clinical Trials - Page for all topic chapter links


Topic Chapters provide detailed, textbook-like information on various aspects of pragmatic clinical trials, complete with citations and links to resources.

Introduction Conflict of Interest Informed Consent Patient-Reported Outcomes Regulatory Issues Learning Healthcare Systems EHR Phenotyping

Rethinking Clinical Trials - Page for all links for Tools for Research


Tools for Research encompasses practical guidance and "toolkits" for conducting different aspects of pragmatic clinical research.

Electronic Phenotyping Biostatistical Guidances Data QualityComputer-Adaptive Testing Patient-Reported Outcomes White Papers Writing for Clinical Research Intro to Pragmatic Clinical Trials

Link for front page of Living Textbook blog


The Living Textbook Blog offers news and updates related to pragmatic clinical research, as well as bulletins about new content available on Rethinking Clinical Trials and the NIH Collaboratory Knowledge Repository.

Blog Front Page RSS Feed Knowledge Repository Collaboratory Grand Rounds

Originally published on January 3, 2014.
Updated April 13, 2015.

  • RSS feed for the Living Textbook  Subscribe to news and updates from the Rethinking Clinical Trials.
  • Questions or comments about Rethinking Clinical Trials can be submitted via email. Please add "Living Textbook" to the Subject line of the email.
  • Follow the NIH Collaboratory on Twitter


Welcome to the Living Textbook: Welcome to the Living Textbook. In: Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials. Bethesda, MD: NIH Health Care Systems Research Collaboratory. Available at: https://rethinkingclinicaltrials.org/welcome-to-rethinking-clinical-trials/. Updated May 21, 2019.