Welcome to your source for training materials on how to design, conduct, and disseminate embedded pragmatic clinical trials (ePCTs). These materials reflect the knowledge, insight, and best practices acquired by the NIH Collaboratory program and its ePCT Demonstration Projects. The resources are being shared with the research community to provide guidance about building partnerships with health systems and overcoming the challenges of conducting pragmatic research. We hope you find this information useful in implementing ePCTs.
We encourage use of these training materials and ask that credit be given to the NIH Health Care Systems Research Collaboratory. For more information, visit the section on How to Cite the Living Textbook.
Drs. Lesley Curtis and Wendy Weber of the NIH Collaboratory discuss highlights from the inaugural ePCT Training Workshop and plans for making more training resources available in the future.
- Quick Start Guide March 25, 2020
Sign up to receive the The NIH Collaboratory Quick Start Guide for Investigators. This guide is designed for clinical investigators interested in learning how to conduct an embedded pragmatic clinical trial (ePCT).
- Intraclass Correlation Coefficient Cheat Sheet March 16, 2020
An introductory description of the intraclass correlation coefficient, a descriptive statistic that is important for the design and analysis of cluster-randomized trials
- ePCT Seminar: American Society of Nephrology December 13, 2019
A 2-hour seminar on conducting embedded PCTs with a focus on interventions that are relevant to the nephrology research community
- Essentials of ePCTs Seminar: AcademyHealth 2019 June 12, 2019
An electronic booklet from the June 1, 2019, full-day preconference seminar hosted by AcademyHealth in partnership with the NIH Collaboratory
- Introduction to ePCTs: Self-Paced Study January 17, 2019
Ten self-paced learning modules on how to design, conduct, and disseminate ePCTs
Upcoming Learning Opportunities
Grand Rounds April 10: Hydroxychloroquine for the Early Treatment of COVID-19 in Hospitalized Adults: A Multicenter Randomized Clinical TrialApril 10 @ 1:00 pm - 2:00 pm
Grand Rounds April 17: Using Real-World Data to Plan Eligibility Criteria and Enhance Recruitment: Actionable Recommendations and Resources from the Clinical Trials Transformation InitiativeApril 17 @ 1:00 pm - 2:00 pm
Living Textbook Grand Rounds Series May 1: Part 4-Choosing What to Measure and Making it Happen: Your Keys to Pragmatic Trial SuccessMay 1 @ 1:00 pm - 2:00 pm
Living Textbook Grand Rounds Series June 19: Part 5-Demystifying Biostatistical Concepts for Embedded Pragmatic Clinical TrialsJune 19 @ 1:00 pm - 2:00 pm
- April 6, 2020: Convening Pain Management Expertise in the Patient-Centered Outcomes Core: An Interview with Dr. Kevin Weinfurt The Collaboratory recently interviewed Kevin Weinfurt, PhD, co-chair of the Patient-Centered Outcomes Core working group, to hear about the Core’s plans for supporting the PRISM Demonstration Projects. In this video, ...
- April 2, 2020: EHR Core Seeks to Advance Routine Collection and Measurement of Pain Data: An Interview With Dr. Rachel Richesson and Dr. Keith Marsolo The NIH Collaboratory’s Electronic Health Records (EHR) Core Working Group supports the Demonstration Projects by facilitating multisite research collaborations between investigators and data stewards and by developing tools and approaches ...
- April 1, 2020: NIH Collaboratory Holds COVID-19 Grand Rounds Series, Promotes Resources for Research Community Using its popular Grand Rounds platform, the NIH Collaboratory Coordinating Center has launched a new effort to share late-breaking research and promote resources in support of clinical researchers affected by ...