Welcome to your source for training materials on how to design, conduct, and disseminate embedded pragmatic clinical trials (ePCTs). These materials reflect the knowledge, insight, and best practices acquired by the NIH Collaboratory program and its ePCT Demonstration Projects. The resources are being shared with the research community to provide guidance about building partnerships with health systems and overcoming the challenges of conducting pragmatic research. We hope you find this information useful in implementing ePCTs.
We encourage use of these training materials and ask that credit be given to the NIH Health Care Systems Research Collaboratory. For more information, visit the section on How to Cite the Living Textbook.
Drs. Lesley Curtis and Wendy Weber of the NIH Collaboratory discuss highlights from the inaugural ePCT Training Workshop and plans for making more training resources available in the future.
- Essentials of ePCTs Seminar Materials June 12, 2019
An electronic booklet from the June 1, 2019, full-day preconference seminar hosted by AcademyHealth in partnership with the NIH Collaboratory
- Introduction to ePCTs: Self-Paced Study January 17, 2019
Ten self-paced learning modules on how to design, conduct, and disseminate ePCTs
- NIH-Hosted ePCT Workshops January 17, 2019
Recordings and materials from NIH-hosted workshops with ePCT thought leaders and stakeholders
Upcoming Learning Opportunities
Grand Rounds November 15: PCORnet: Health Plan Research Network Data Linkage and Patient Engagement with Patient-Powered Research NetworksNovember 15 @ 1:00 pm - 2:00 pm
IMPACT Collaboratory: Are You Ready for a Pragmatic Trial? The RAPT Model and Implementation ConsiderationsNovember 21 @ 12:00 pm - 1:00 pm
- November 22 @ 1:00 pm - 2:00 pm
- November 29 @ 1:00 pm - 2:00 pm
- November 1, 2019: Collaboratory PIs Give Advice to New Pragmatic Trials The NIH Health Care Systems Research Collaboratory program is welcoming new embedded pragmatic clinical trials (ePCTs) on pain management and reducing opioid prescribing as part of the NIH’s Helping to ...
- October 30, 2019: Baseline Covariate Imbalance Influences Treatment Effect Bias in Cluster Randomized Trials In a study supported by the NIH Collaboratory, researchers found that imbalance in individual-level baseline covariates influences bias in the observed treatment effect in cluster randomized trials. Using race as ...
- October 28, 2019: Latest Ethics and Regulatory Updates from Demonstration Projects Available Six Collaboratory Demonstration Projects—ACP PEACE, EMBED, GGC4H, HiLo, Nudge, and PRIM-ER—have recently transitioned from the planning to implementation phase of their embedded pragmatic clinical trial (ePCT). During the transition, study ...