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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240403T120000
DTEND;TZID=America/New_York:20240403T130000
DTSTAMP:20260501T135715
CREATED:20240129T161419Z
LAST-MODIFIED:20240129T161419Z
UID:33058-1712145600-1712149200@rethinkingclinicaltrials.org
SUMMARY:NIH Clinical Center Grand Rounds: “How Can We Respect the Dead?”
DESCRIPTION:NIH Clinical Center Grand Rounds: “How Can We Respect the Dead?”\nDiscussant: Neal Dickert MD\, PhD\nThomas R. Williams Professor of Medicine\, Emory University\nhttps://videocast.nih.gov/
URL:https://rethinkingclinicaltrials.org/event/nih-clinical-center-grand-rounds-how-can-we-respect-the-dead/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240405T130000
DTEND;TZID=America/New_York:20240405T140000
DTSTAMP:20260501T135715
CREATED:20240305T144849Z
LAST-MODIFIED:20240305T144849Z
UID:33470-1712322000-1712325600@rethinkingclinicaltrials.org
SUMMARY:Grand Rounds April 5\, 2024: A New Look at P Values for Randomized Clinical Trials (Erik van Zwet\, PhD)
DESCRIPTION:Speaker: \nErik van Zwet\, PhD\nDepartment of Biomedical Data Sciences\nLeiden University Medical Center\, the Netherlands \nTitle: A New Look at P Values for Randomized Clinical Trials \nDate: Friday\, April 5\, 2024\, 1:00-2:00 p.m. ET \nTo join the online meeting: \nClick the Zoom Meeting link below: \nhttps://duke.zoom.us/j/98292370425?pwd=S05sOU42WXp3NXNjK0ZkczN0WXpHUT09 \nMeeting ID: 982 9237 0425 \nPasscode: 237056 \nOne Tap Mobile \n+13126266799\,\,98292370425#\,\,\,\,*237056# US (Chicago) \n+16468769923\,\,98292370425#\,\,\,\,*237056# US (New York) \nFind your local number: https://duke.zoom.us/u/acEzZCxM5z \nAudio Dial in Options \nUS:  +1 309 205 3325 US \nInternational: https://duke.zoom.us/u/acGjMcvNR6 \nMeeting ID: 982 9237 0425 \nPasscode: 237056
URL:https://rethinkingclinicaltrials.org/event/grand-rounds-april-5-2024-a-new-look-at-p-values-for-randomized-clinical-trials-erik-van-zwet-phd/
CATEGORIES:Grand Rounds Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240405T133000
DTEND;TZID=America/Toronto:20240405T143000
DTSTAMP:20260501T135715
CREATED:20240330T180113Z
LAST-MODIFIED:20240402T153921Z
UID:33649-1712323800-1712327400@rethinkingclinicaltrials.org
SUMMARY:2024 Allan Donner Lecture: The Unit of Inference in Cluster Randomized Trials
DESCRIPTION:2024 Allan Donner Lecture: Dr. Fan Li\nDate: Friday\, April 5\nTime: 1:30 pm – 2:30 pm\nLocation: PHFM 3015 (Western Centre for Public Health and Family Medicine) or Zoom (link may be requested at EpiBio@uwo.ca)\nLink: https://www.schulich.uwo.ca/epibio/about_us/events/2024/2024_Allan_Donner_Lecture.html \nThe unit of inference in cluster randomized trials\nFan Li\n\nAssistant Professor \nDepartment of Biostatistics\nYale School of Public Health\,\nYale Center for Methods in Implementation and Prevention Science \nShort Biography:\nFan Li is a tenure-track Assistant Professor in the Department of Biostatistics at Yale School of Public Health\, and Yale Center for Methods in Implementation and Prevention Science. He obtained his PhD in Biostatistics from Duke University in 2019 and joined the Yale faculty since 2019. His research aims to develop methods for designing and analyzing cluster randomized trials\, causal inference methods for estimand-aligned analyses of randomized experiments and observational studies. Dr. Li’s methodology research has been funded by multiple awards from the United States National Institutes of Health and Patient-Centered Outcome Research Institute as a principal investigator and a co-investigator. He has published over 120 peer-reviewed articles. He is Co-Editor in Chief of the journal\, Epidemiologic Methods\, and Associate Editor of several journals including Statistics in Medicine\, Clinical Trials\, and Implementation Science. \nAbstract: \nIn cluster randomized trials\, intact clusters of individuals rather than individuals themselves are randomly assigned to treatment conditions\, creating a two-level structure that complicates the design and analysis compared to individually randomized trials. While the need to address intracluster correlations has motivated a robust literature for designing and analyzing cluster randomized trials in the past two decades\, fewer efforts have integrated these developments in the context of treatment effect estimands. On page 13 of Donner and Klar (2000)\, it has already been suggested that “the target of inference in such studies (CRTs) could be at either the individual level or community level”\, but the philosophy around unit of inference seems to be lost in translation until recently. In this presentation\, we emphasize the difference between the unit of inference and the unit of analysis\, and use the potential outcomes notation to define estimands that represent the unit of inference\, regardless of the unit of analysis. In addition\, we explain how one can standardize the output from any familiar regression model to ensure estimand-aligned inference. A key take-away is that one does not need to forgo the conventional wisdom developed in the existing literature to obtain the right inferential target\, as long as the unit of inference is specified a priori\, and a robust standardization procedure is applied to process the regression model output. \nKeywords:\nCluster randomized trials; Stepped wedge designs; Causal inference; Estimands; Observational studies; Semiparametric methods. \nWebsite
URL:https://rethinkingclinicaltrials.org/event/2024-allan-donner-lecture-the-unit-of-inference-in-cluster-randomized-trials/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240412T130000
DTEND;TZID=America/New_York:20240412T140000
DTSTAMP:20260501T135715
CREATED:20240321T135410Z
LAST-MODIFIED:20240410T130515Z
UID:33582-1712926800-1712930400@rethinkingclinicaltrials.org
SUMMARY:Grand Rounds April 12\, 2024: Primary Palliative Care for Emergency Medicine\, a Cluster Randomized Stepped-Wedge Trial Across 33 Emergency Departments (Corita R. Grudzen\, MD\, MSHS\, FACEP)
DESCRIPTION:Speaker: \nCorita R. Grudzen\, MD\, MSHS\, FACEP\nFern Grayer Chair in Oncology Care and the Patient Experience\nDivision Head\, Supportive and Acute Care Services\nMemorial Sloan Kettering Cancer Center\nProfessor of Emergency Medicine\nWeill Cornell Medical College \nTitle: Primary Palliative Care for Emergency Medicine\, A Cluster Randomized Stepped-Wedge Trial Across 33 Emergency Departments \nDate: Friday\, April 12\, 2024\, 1:00-2:00 p.m. ET \nTo join the online meeting: \nClick the Zoom Meeting link below: \nhttps://duke.zoom.us/j/93950781119?pwd=SUhsTFJvbGIzYUozY0NpdTVZRFJBQT09 \nMeeting ID: 939 5078 1119 \nPasscode: 392858 \nOne tap mobile \n+13052241968\,\,93950781119#\,\,\,\,*392858# US \n+13092053325\,\,93950781119#\,\,\,\,*392858# US \nAudio only options:  \n\n+1 305 224 1968 US\n+1 309 205 3325 US\n\nMeeting ID: 939 5078 1119 \nPasscode: 392858
URL:https://rethinkingclinicaltrials.org/event/grand-rounds-april-12-2024-primary-palliative-care-for-emergency-medicine-a-clustered-randomized-stepped-wedge-trial-across-33-emergency-departments-corita-r-grudzen-md-mshs-facep/
CATEGORIES:Grand Rounds Event
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240419T130000
DTEND;TZID=America/New_York:20240419T140000
DTSTAMP:20260501T135715
CREATED:20240401T131907Z
LAST-MODIFIED:20240416T124605Z
UID:33655-1713531600-1713535200@rethinkingclinicaltrials.org
SUMMARY:Grand Rounds April 19\, 2024: The Yale Open Data Access (YODA) Project: 10 Years of Clinical Trial Data Sharing (Joseph S. Ross\, MD\, MHS)
DESCRIPTION:Speaker: \nJoseph S. Ross\, MD\, MHS\nProfessor of Medicine and Public Health\nYale University \nTitle: The Yale Open Data Access (YODA) Project: 10 Years of Clinical Trial Data Sharing \nDate: Friday\, April 19\, 2024\, 1:00-2:00 p.m. ET \nTo join the online meeting: \nClick the Zoom Meeting link below:\nhttps://duke.zoom.us/j/93696931854?pwd=dXUySnkzYkNwK1NQeHVHWjRKR1ptUT09\nMeeting ID: 936 9693 1854\nPasscode: 854800 \nOne tap mobile \n+13017158592\,\,93696931854#\,\,\,\,*854800# US +13052241968\,\,93696931854#\,\,\,\,*854800# US \nAudio Only Option: \n\n+1 301 715 8592 US\n\nMeeting ID: 936 9693 1854\nPasscode: 854800
URL:https://rethinkingclinicaltrials.org/event/grand-rounds-april-19-2024-the-yale-open-data-access-yoda-project-10-years-of-clinical-trial-data-sharing-joseph-s-ross-md-mhs/
CATEGORIES:Grand Rounds Event
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240426T130000
DTEND;TZID=America/New_York:20240426T140000
DTSTAMP:20260501T135715
CREATED:20240416T125012Z
LAST-MODIFIED:20240416T125012Z
UID:33821-1714136400-1714140000@rethinkingclinicaltrials.org
SUMMARY:Grand Rounds April 26\, 2024: Waiver or Alteration of Informed Consent for Minimal Risk Clinical Investigations – FDA Regulation Development and Research Landscape (Lauren Milner\, PhD; Jonathan Casey\, MD\, MSCI; Matthew Semler\, MD\, MSCI)
DESCRIPTION:Speakers: \nLauren Milner\, PhD\nOffice of Clinical Policy\nUS Food and Drug Administration  (FDA) \nJonathan Casey\, M.D.\, MSCI\nAssistant Professor\, Division of Pulmonary and Critical Care Medicine\nVanderbilt University Medical Center\nDirector\, Coordinating Center Pragmatic Critical Care Research Group \nMatthew Semler\, M.D.\, MSCI\nAssociate Professor\, Division of Pulmonary and Critical Care Medicine\nVanderbilt University Medical Center\nDirector\, Steering Committee Pragmatic Critical Care\nResearch Group\nCo-Director\, Vanderbilt Center for Learning Healthcare \nTitle: Waiver or Alteration of Informed Consent for Minimal Risk Clinical Investigations – FDA Regulation Development and Research Landscape \nDate: Friday\, April 26\, 2024\, 1:00-2:00 p.m. ET \nTo join the online meeting: \nClick the Zoom Meeting link below: \nhttps://duke.zoom.us/j/97193707495?pwd=U3VlMmVKUmRqWnRnRTBxL3p3MGNUdz09 \nMeeting ID: 971 9370 7495 \nPasscode: 947899 \nOne tap mobile: \n+16469313860\,\,97193707495#\,\,\,\,*947899# US \n+13017158592\,\,97193707495#\,\,\,\,*947899# US (Washington DC) \nAudio Option: \n\n+1 646 931 3860 US\n\nMeeting ID: 971 9370 7495 \nPasscode: 947899
URL:https://rethinkingclinicaltrials.org/event/grand-rounds-april-26-2024-waiver-or-alteration-of-informed-consent-for-minimal-risk-clinical-investigations-fda-regulation-development-and-research-landscape-lauren-milner-phd-jonathan/
CATEGORIES:Grand Rounds Event
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