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X-WR-CALDESC:Events for Rethinking Clinical Trials
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DTSTART;TZID=America/New_York:20221103T150000
DTEND;TZID=America/New_York:20221103T150000
DTSTAMP:20260613T114520
CREATED:20221019T200644Z
LAST-MODIFIED:20221019T200857Z
UID:28441-1667487600-1667487600@rethinkingclinicaltrials.org
SUMMARY:Toward Causal Inference in Cluster Randomized Trials: Estimands and Reflection on Current Practice
DESCRIPTION:Methods: Minds the Gap Webinar Series\n“Toward Causal Inference in Cluster Randomized Trials: Estimands and Reflection on Current Practice”\nFan Li\, PhD; Yale School of Public Health\nNational Institutes of Health\, Office of Disease Prevention \n\n\n\nCluster randomized trials (CRTs) involve randomizing groups of individuals to different interventions. While model-based methods are extensively studied for analyzing CRTs\, there has been little reflection around the treatment effect estimands at the outset. In the first part of this presentation\, we describe two relevant estimands that can be addressed through CRTs and point out that they can differ when the treatment effects vary according to cluster sizes. As a cautionary note\, we demonstrate how choices between different analytic approaches can impact the interpretation of results by fundamentally changing the question being asked. In the second part\, we revisit the linear mixed model as the most commonly used method for analyzing CRTs. The linear mixed model makes stringent assumptions\, including normality\, linearity\, and typically a compound symmetric correlation structure\, all of which may be challenging to verify. However\, under certain conditions\, we show that the linear mixed model consistently estimates the average causal effect under arbitrary misspecification of its working model. Under equal randomization\, its model-based variance estimator\, surprisingly\, remains consistent under model misspecification\, justifying the use of confidence intervals output by standard software. These results hold under both simple and stratified randomization\, and serve as an important causal inference justification for linear mixed models. Caveats and extensions of our findings will also be mentioned. \nFor more information\, visit https://prevention.nih.gov/education-training/methods-mind-gap/toward-causal-inference-cluster-randomized-trials-estimands-and-reflection-current-practice.
URL:https://rethinkingclinicaltrials.org/event/toward-causal-inference-in-cluster-randomized-trials-estimands-and-reflection-on-current-practice/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20221104T130000
DTEND;TZID=America/New_York:20221104T140000
DTSTAMP:20260613T114520
CREATED:20221014T144713Z
LAST-MODIFIED:20221102T114334Z
UID:28325-1667566800-1667570400@rethinkingclinicaltrials.org
SUMMARY:Grand Rounds November 4\, 2022: The CardioNerds Clinical Trials Network: Pairing Equitable Enrollment With Trainee Development (Amit Goyal\, MD\, MAS)
DESCRIPTION:Speaker: \nAmit Goyal\, MD\, MAS\nInterventional/Structural Fellow\, Cleveland Clinic\nCofounder of CardioNerds \nTopic: The CardioNerds Clinical Trials Network: Pairing Equitable Enrollment With Trainee Development \nDate: Friday\, November 4\, 2022\, 1:00-2:00 p.m. ET \n  \nMeeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files\, go to https://dukemed.webex.com/dukemed/systemdiagnosis.php. \nTo join the online meeting:\nGo to https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6 \nClick ‘Connect to Audio”\nChoose ‘Computer Audio’ or ‘I will call in’.\nIf using the ‘call in option’\, follow the information from the dialog box that appears.\nBe certain to use the Access Code AND the Attendee ID. \nTroubleshooting:\nIf the URL above does not work\, go to dukemed.webex.com and enter:\nMeeting Number: 2622 682 0537\nMeeting Password: 12345 \nFor Audio ONLY:\nCall-in toll number (US/Canada): 1-650-479-3207\nAccess code: 2622 682 0537 \nNOTE: For Toll-free users\, the call-back (call me) services are also available.
URL:https://rethinkingclinicaltrials.org/event/grand-rounds-november-4-2022-the-cardionerds-clinical-trials-network-pairing-equitable-enrollment-with-trainee-development-amit-goyal-md-mas/
CATEGORIES:Grand Rounds Event
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20221111T130000
DTEND;TZID=America/New_York:20221111T140000
DTSTAMP:20260613T114520
CREATED:20220809T191046Z
LAST-MODIFIED:20220809T191046Z
UID:27755-1668171600-1668175200@rethinkingclinicaltrials.org
SUMMARY:Grand Rounds Ethics and Regulatory Series November 11: Data Sharing and Pragmatic Clinical Trials: Law & Ethics Amidst a Changing Policy Landscape (Stephanie Morain\, PhD\, MPH; Kayte Spector-Bagdady\, JD\, MBioethics)
DESCRIPTION:Speaker: \nStephanie Morain\, PhD\, MPH\nAssistant Professor\nBerman Institute of Bioethics & Johns Hopkins Bloomberg School of Public Health \nKayte Spector-Bagdady\, JD\, MBioethics\nAssociate Director\, Center for Bioethics & Social Sciences in Medicine\nAssistant Professor of Obstetrics & Gynecology\nUniversity of Michigan Medical School \nTopic: Data Sharing and Pragmatic Clinical Trials: Law & Ethics Amidst a Changing Policy Landscape\nDate: Friday\, November 11\, 2022\, 1:00-2:00 p.m. ET \n  \nMeeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files\, go to https://dukemed.webex.com/dukemed/systemdiagnosis.php. \nTo join the online meeting:\nGo to https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6 \nClick ‘Connect to Audio”\nChoose ‘Computer Audio’ or ‘I will call in’.\nIf using the ‘call in option’\, follow the information from the dialog box that appears.\nBe certain to use the Access Code AND the Attendee ID. \nTroubleshooting:\nIf the URL above does not work\, go to dukemed.webex.com and enter:\nMeeting Number: 2622 682 0537\nMeeting Password: 12345 \nFor Audio ONLY:\nCall-in toll number (US/Canada): 1-650-479-3207\nAccess code: 2622 682 0537 \nNOTE: For Toll-free users\, the call-back (call me) services are also available.
URL:https://rethinkingclinicaltrials.org/event/grand-rounds-ethics-and-regulatory-series-november-11-data-sharing-and-pragmatic-clinical-trials-law-kayte-spector-bagdady-j/
CATEGORIES:Grand Rounds Event
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20221118T130000
DTEND;TZID=America/New_York:20221118T140000
DTSTAMP:20260613T114520
CREATED:20221019T211144Z
LAST-MODIFIED:20221019T211144Z
UID:28449-1668776400-1668780000@rethinkingclinicaltrials.org
SUMMARY:Grand Rounds November 18\, 2022: The FIRST-ABC Pragmatic Trials of Non-Invasive Respiratory Support In Children (Padmanabhan Ramnarayan\, MBBS\, MD\, FRCPCH\, FFICM)
DESCRIPTION:Speaker: \nPadmanabhan Ramnarayan (Ram)\, MBBS\, MD\, FRCPCH\, FFICM\nReader in Pediatric Critical Care\nImperial College London \nTopic: The FIRST-ABC Pragmatic Trials of Non-Invasive Respiratory Support In Children \nDate: Friday\, November 18\, 2022\, 1:00-2:00 p.m. ET \n  \nMeeting Info: To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files\, go to https://dukemed.webex.com/dukemed/systemdiagnosis.php. \nTo join the online meeting:\nGo to https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6 \nClick ‘Connect to Audio”\nChoose ‘Computer Audio’ or ‘I will call in’.\nIf using the ‘call in option’\, follow the information from the dialog box that appears.\nBe certain to use the Access Code AND the Attendee ID. \nTroubleshooting:\nIf the URL above does not work\, go to dukemed.webex.com and enter:\nMeeting Number: 2622 682 0537\nMeeting Password: 12345 \nFor Audio ONLY:\nCall-in toll number (US/Canada): 1-650-479-3207\nAccess code: 2622 682 0537 \nNOTE: For Toll-free users\, the call-back (call me) services are also available.
URL:https://rethinkingclinicaltrials.org/event/grand-rounds-november-18-2022-the-first-abc-pragmatic-trials-of-non-invasive-respiratory-support-in-children-padmanabhan-ramnarayan-mbbs-md-frcpch-fficm/
CATEGORIES:Grand Rounds Event
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