Rethinking Clinical Trials

Grand Rounds November 26: No Presentation (Thanksgiving Holiday)
2021-11-26 13:00 - 14:00 (America/New_York)

Grand Rounds December 3: Primary Care-Based Behavioral Treatment for Long Term Opioid Users with Chronic Pain: Primary Results and Lessons Learned from the PPACT Pragmatic Trial
2021-12-03 13:00 - 14:00
Speaker:
Lynn DeBar, PhD MPH
Senior Scientist
Kaiser Permanente Washington Health Research Institute
Seattle, WA
Topic: Primary Care-Based Behavioral Treatment for Long Term Opioid Users with Chronic Pain: Primary Results and Lessons Learned from the PPACT Pragmatic Trial
Date: Friday, December 3, 2021, 1:00-2:00 p.m. ET
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Grand Round December 10: Decentralized Trials: Naughty or Nice?
2021-12-10 13:00 - 14:00
Speaker:
Adrian F. Hernandez, MD, MHS
Executive Director, Duke Clinical Research Institute
Vice Dean, Duke University School of Medicine
Topic: Decentralized Trials: Naughty or Nice?
Date: Friday, December 10, 2021, 1:00-2:00 p.m. ET
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Grand Rounds December 17: Cyberthreat, Cybersecurity and Cyber Compliance in Clinical Research and Healthcare: One Size Fits None
2021-12-17 13:00 - 14:00
Speaker:
Eric Perakslis PhD
Chief Science & Digital Officer
Duke Clinical Research Institute
Professor
Department of Population Health Sciences
Chief Research Technology Strategist
Duke University School of Medicine
Topic: Cyberthreat, Cybersecurity and Cyber Compliance in Clinical Research and Healthcare: One Size Fits None
Date: Friday, December 17, 2021, 1:00-2:00 p.m. ET
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Grand Rounds December 24: No Presentation (Holiday Break)
2021-12-24 13:00 - 14:00

Grand Rounds December 31: No Presentation (Holiday Break)
2021-12-31 13:00 - 14:00

Grand Rounds January 7: D-PRESCRIBE-AD: A Pragmatic Trial to Educate and Sensitize Caregivers and Healthcare Providers to Reduce Inappropriate Prescription Burden in Persons Living with Dementia
2022-01-07 13:00 - 14:00
Speakers:
Jerry H. Gurwitz, MD
Chief, Division of Geriatric Medicine
University of Massachusetts Medical School and UMass Memorial Medical Center
Executive Director, Meyers Health Care Institute
A joint endeavor of University of Massachusetts Medical School, Fallon Health, and Reliant Medical Group
Richard Platt, M.D., M.Sc.
President, Harvard Pilgrim Health Care Institute
Topic: D-PRESCRIBE-AD: A Pragmatic Trial to Educate and Sensitize Caregivers and Healthcare Providers to Reduce Inappropriate Prescription Burden in Persons Living with Dementia
Date: Friday, January 7, 2022, 1:00-2:00 p.m. ET
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Grand Rounds January 14: Searching for a Unicorn: Understanding Stakeholder Perspectives When Selecting Outcomes for Outpatient Trials
2022-01-14 13:00 - 14:00
Speaker:
Christopher Lindsell, PhD
Professor of Biostatistics and Biomedical Informatics
Director, Vanderbilt Institute for Clinical and Translational Research (VICTR) Methods Program
Codirector, Vanderbilt Health Data Science (HEADS) Center
Topic: Searching for A Unicorn: Understanding Stakeholder Perspectives When Selecting Outcomes for Outpatient Trials
Date: Friday, January 14, 2022, 1:00-2:00 p.m. ET
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Grand Rounds January 21: Primary Palliative Care for Emergency Medicine
2022-01-21 13:00 - 14:00
Speaker:
Corita R. Grudzen, MD, MSHS, FACEP
Professor, Emergency Medicine and Population Health
Associate Dean, Clinical Sciences
Deputy Director, Clinical and Translational Science Institute
Vice Chair for Research, Emergency Medicine
Ronald O. Perelman Department of Emergency Medicine
NYU Grossman School of Medicine
Topic: Primary Palliative Care for Emergency Medicine
Date: Friday, January 21, 2022, 1:00-2:00 p.m. ET
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Grand Rounds January 28: EMBED Trial Results: Pragmatic Trial of User-Centered Clinical Decision Support to Implement Emergency Department-Initiated Buprenorphine for Opioid Use Disorder
2022-01-28 13:00 - 14:00
Speakers:
Edward R Melnick, MD, MHS
Associate Professor of Emergency Medicine, Yale School of Medicine
Associate Professor of Biostatistics (Health Informatics), Yale School of Public Health
Program Director, Yale-VA Clinical Informatics Fellowship Program
Gail D’Onofrio, MD, MS
Albert E. Kent Professor of Emergency Medicine
Yale School of Medicine
Professor of Public Health, Chronic Disease & Epidemiology
Yale School of Public Health
Topic: EMBED Trial Results: Pragmatic Trial of User-Centered Clinical Decision Support to Implement Emergency Department-Initiated Buprenorphine for Opioid Use Disorder
Date: Friday, January 28, 2022, 1:00-2:00 p.m. ET
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Grand Rounds February 4: SPIRRIT-HFpEF: Opportunities and Challenges in a Large Registry-Based Randomized Clinical Trial
2022-02-04 13:00 - 14:00
Speakers:
Adam DeVore, MD, MHS
Associate Professor of Medicine
Duke University Medical Center
Duke Clinical Research Institute
Lars Lund, MD, PhD
Professor of Cardiology
Karolinska Institutet
Karolinska University Hospital
Topic: SPIRRIT-HFpEF: Opportunities and Challenges in a Large Registry-based Randomized Clinical Trial
Date: Friday, February 4, 2022, 1:00-2:00 p.m. ET
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Grand Rounds February 11: Great Power and Great Responsibility: Machine Learning in Clinical Research(E. Hope Weissler, MD, MHS; Erich Huang, MD, PhD)
2022-02-11 13:00 - 14:00
Speakers:
E. Hope Weissler, MD, MHS
Resident, Vascular and Endovascular Surgery
Duke University School of Medicine
Erich Huang, MD, PhD
Chief Science and Innovation Officer, Onduo
Topic: Great Power and Great Responsibility: Machine Learning in Clinical Research
Date: Friday, February 11, 2022, 1:00-2:00 p.m. ET
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Grand Rounds February 18: Building a Resource: The Process of Developing a Trans-stakeholder Framework to Enable Pediatric Drug Development(Perdita Taylor-Zapata, MD)
2022-02-18 13:00 - 14:00
Speaker:
Perdita Taylor-Zapata, MD
Best Pharmaceuticals for Children Act (BPCA) Program Lead and NICHD Program Officer
Obstetric and Pediatric Pharmacology and Therapeutics Branch
National Institute of Child Health and Human Development
Topic: Building a Resource: The Process of Developing a Trans-stakeholder Framework to Enable Pediatric Drug Development
Date: Friday, February 18, 2022, 1:00-2:00 p.m. ET
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Grand Rounds February 25: The Next Generation of Patient-Centered Trials – No Site Visits, Home-delivery of Meds and Patient-reported Outcomes – The CHIEF-HF Trial(John Spertus MD MPH FACC FAHA)
2022-02-25 13:00 - 14:00
Speaker:
John Spertus, MD MPH FACC FAHA
Daniel Lauer/Missouri Endowed Chair and Professor
University of Missouri – Kansas City
Clinical Director of Outcomes Research
Saint Luke’s Mid America Heart Institute
Topic: The Next Generation of Patient-Centered Trials – No Site Visits, Home-delivery of Meds and Patient-reported Outcomes – The CHIEF-HF Trial
Date: Friday, February 25, 2022, 1:00-2:00 p.m. ET
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Grand Rounds March 4: ACP COVID: A Trial to Evaluate an Advance Care Planning Video and Communication Skills Training Intervention for Older Adults During an Evolving Pandemic (Angelo E. Volandes, MD, MPH; James A. Tulsky, MD; Sophia N. Zupanc, BA)
2022-03-04 13:00 - 14:00
Speakers:
Angelo E. Volandes, MD, MPH
Associate Professor, Harvard Medical School and Massachusetts General Hospital
James A. Tulsky, MD
Chair, Department of Psychosocial Oncology and Palliative Care
Dana-Farber Cancer Institute
Professor of Medicine, Harvard Medical School
Sophia N. Zupanc, BA
Dana-Farber Cancer Institute
Topic: ACP COVID: A Trial to Evaluate an Advance Care Planning Video and Communication Skills Training Intervention for Older Adults During an Evolving Pandemic
Date: Friday, March 4, 2022, 1:00-2:00 p.m. ET
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Grand Rounds March 11: Understanding a Patient’s Daily Experience Through Mobile Devices and Wearables: Lessons Learned From the 8,000 Patient MIPACT Study and Implementation in a National Pragmatic Trial (Sachin Kheterpal, MD, MBA; Jessica Golbus, MD; Nicole Pescatore, MPH)
2022-03-11 13:00 - 14:00
Speakers:
Sachin Kheterpal, MD, MBA
Professor of Anesthesiology
Associate Dean for Research IT
PI for MIPACT and Co-PI for THRIVE University of Michigan
Jessica Golbus, MD
Clinical Instructor, Cardiovascular Medicine
Co-I for MIPACT
University of Michigan
Nicole Pescatore, MPH
MIPACT Clinical Research Project Manager University of Michigan

Topic: Understanding a Patient’s Daily Experience Through Mobile Devices and Wearables: Lessons Learned From the 8,000 Patient MIPACT Study and Implementation in a National Pragmatic Trial
Date: Friday, March 11, 2022, 1:00-2:00 p.m. ET
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Grand Rounds March 18: Better Data on Ivermectin Is Finally Here: Results from the TOGETHER Trial (Edward Mills, PhD, FRCP; Craig Rayner, PharmD)
2022-03-18 13:00 - 14:00 | https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6
Speakers:
Edward Mills PhD, FRCP
Professor, McMaster University
Craig R Rayner FRCP Edin PharmD MBA
Certara Distinguished Scientist
Adjunct Associate Professor, Monash University

Topic: Better Data on Ivermectin Is Finally Here: Results from the TOGETHER Trial
Date: Friday, March 18, 2022, 1:00-2:00 p.m. ET
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Grand Rounds March 25: A Telehealth-Delivered Pragmatic Trial of Mindfulness for Persons with Chronic Low Back Pain (Natalia Morone, MD, MS)
2022-03-25 13:00 - 14:00
Speaker:
Natalia E. Morone, MD, MS
Associate Professor of Medicine
Boston University/Boston Medical Center

Topic: A Telehealth-Delivered Pragmatic Trial of Mindfulness for Persons with Chronic Low Back Pain
Date: Friday, March 25, 2022, 1:00-2:00 p.m. ET
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Grand Rounds April 1: ICD-Pieces: Improving Care for CKD, Diabetes and Hypertension in Health Systems (Miguel A. Vazquez, MD; George (Holt) Oliver, MD, PhD)
2022-04-01 13:00 - 14:00
Speakers:
Miguel A. Vazquez, MD
Professor of Medicine
University of Texas Southwestern Medical Center
Dallas, TX
George (Holt) Oliver, MD, PhD
Vice President Clinical Informatics
Parkland Center for Clinical Innovation
Dallas, TX

Topic: ICD-Pieces: Improving Care for CKD, Diabetes and Hypertension in Health Systems
Date: Friday, April 1, 2022, 1:00-2:00 p.m. ET
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Grand Rounds April 8: COVID-19 Surveillance in PCORnet: Year 2 Update (Jason Block, MD, MPH; Thomas W. Carton, PhD, MS)
2022-04-08 13:00 - 14:00 | https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6
Speaker:
Jason Block, MD, MPH
Associate Professor
Harvard Pilgrim Health Care Institute
Harvard Medical School
Thomas W. Carton, PhD, MS
Chief Data Officer
Louisiana Public Health Institute
Topic: COVID-19 Surveillance in PCORnet: Year 2 Update
Date: Friday, April 8, 2022, 1:00-2:00 pm ET
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Grand Rounds April 15: SODIUM-HF: Should Our Patients Consume Less Dietary Sodium? (Justin A. Ezekowitz, MBBCh, MSc)
2022-04-15 13:00 - 14:00 | https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6
Speaker:
Justin A. Ezekowitz, MBBCh, MSc
Professor of Medicine and Alberta Health Services Chair in Cardiac Sciences
Director, Cardiovascular Research
Co-Director, Canadian VIGOUR Centre
University of Alberta
Cardiologist, Mazankowski Alberta Heart Institute
Topic: SODIUM-HF: Should Our Patients Consume Less Dietary Sodium?
Date: Friday, April 15, 2022, 1:00-2:00 pm ET
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Grand Rounds April 22: Development of a Novel Research Collaboration with the Retail Industry (Dylan L. Steen, MD, MS; Sarah C. Couch, PhD, RDN)
2022-04-22 13:00 - 14:00
Speaker:
Dylan L. Steen, MD, MS
Adjunct Associate Professor, University of Cincinnati College of Medicine
Director, Clinical Trials and Population Health Research, UC Heart, Lung, and Vascular Institute
CEO, High Enroll LLC (research participant recruitment company)
Sarah C. Couch, PhD, RDN
Professor, Department of Rehabilitation, Exercise and Nutrition Sciences
University of Cincinnati College of Allied Health Sciences
Topic: Development of a Novel Research Collaboration with the Retail Industry
Date: Friday, April 22, 2022, 1:00-2:00 p.m. ET
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Meeting Number: 2622 682 0537
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Grand Rounds April 29: BP Track: National Surveillance for Blood Pressure Control and Related Process Metrics Using PCORnet (Mark J. Pletcher, MD, MPH; Rhonda Cooper-DeHoff, PharmD, MS; Alanna M. Chamberlain, PhD, MPH)
2022-04-29 13:00 - 14:00 | https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6
Speakers:
Mark J. Pletcher, MD, MPH
Professor of Epidemiology and Biostatistics and Medicine
University of California, San Francisco
Rhonda Cooper-DeHoff, PharmD, MS, FAHA, FACC, FCCP
Association Professor and Research Foundation Professor
University of Florida College of Pharmacy
Alanna M. Chamberlain, PhD, MPH
Associate Professor of Epidemiology
Mayo Clinic
Topic: BP Track: National Surveillance for Blood Pressure Control and Related Process Metrics Using PCORnet
Date: Friday, April 29, 2022, 1:00-2:00 p.m. ET
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Grand Rounds May 6: N-of-1 Randomized Trials: CRAVE and I-STOP-AFib as Examples (Gregory Marcus, MD, MAS)
2022-05-06 13:00 - 14:00
Speaker:
Gregory Marcus, MD, MAS
Professor of Medicine
University of California, San Francisco

Topic: N-of-1 Randomized Trials: CRAVE and I-STOP-AFib as Examples
Date: Friday, May 6, 2022, 1:00-2:00 p.m. ET
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Grand Rounds May 13: Ethics and Collateral Findings in Pragmatic Clinical Trials: Implications of a Multi-Method Exploration (Jeremy Sugarman, MD, MPH, MA; Stephanie Morain, PhD, MPH; Juli Bollinger, MS; Kevin P. Weinfurt, PhD)
2022-05-13 13:00 - 14:00
Speakers:
Jeremy Sugarman, MD, MPH, MA
Deputy Director for Medicine
Harvey M. Meyerhoff Professor of Bioethics and Medicine
Berman Institute of Bioethics
Johns Hopkins University
Stephanie Morain, PhD, MPH
Assistant Professor
Berman Institute of Bioethics
Johns Hopkins University
Juli Bollinger, MS
Research Scientist
Berman Institute of Bioethics
Johns Hopkins University
Kevin P. Weinfurt, PhD
Professor and Vice Chair of Research
Department of Population Health Sciences
Duke University School of Medicine

Topic: Ethics and Collateral Findings in Pragmatic Clinical Trials: Implications of a Multi-Method Exploration
Date: Friday, May 13, 2022, 1:00-2:00 p.m. ET
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Grand Rounds May 20: Long-COVID Studies Within the RECOVER Platform (Upinder Singh, MD)
2022-05-20 13:00 - 14:00 | https://dukemed.webex.com/dukemed/j.php?MTID=m4c6e3e4827442a92338a5649cee613e6
Speakers:
Upinder Singh, MD
Professor and Division Chief
Division of Infectious Diseases and Geographic Medicine
Stanford University School of Medicine

Topic:
Long-COVID Studies Within the RECOVER Platform
Date: Friday, May 20, 2022, 1:00-2:00 p.m. ET
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Grand Rounds June 3: Results of the MedSafer Study: Electronic Decision Support for Deprescribing in Hospitalized Older Adults (Emily McDonald MDCM, MSc, FRCPC)
2022-06-03 13:00 - 14:00
Speaker:
Emily G. McDonald MDCM, MSc, FRCPC
Scientific Director; Canadian Deprescribing Network
Associate Professor of Medicine; McGill University

Topic: Results of the MedSafer Study: Electronic Decision Support for Deprescribing in Hospitalized Older Adults
Date: Friday, June 3, 2022, 1:00-2:00 p.m. ET
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Grand Rounds June 10: Do We Really Need So Many Heart Failure Clinicians? (Tariq Ahmad, MD, MPH)
2022-06-10 13:00 - 14:00
Speaker:
Tariq Ahmad, MD, MPH
Director, Cardiac Transplant and MCS
Chief, Heart Failure Program
Yale School of Medicine, Yale New Haven Health

Topic: Do We Really Need So Many Heart Failure Clinicians?
Date: Friday, June 10, 2022, 1:00-2:00 p.m. ET
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Meeting Number: 2622 682 0537
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NIH Pragmatic Trials Collaboratory 2022 Annual Workshop Critical Questions for Pragmatic Clinical Trialists: Insights From the NIH Pragmatic Trials Collaboratory’s First Decade
2022-06-15 13:00 - 17:00
The NIH Pragmatic Trials Collaboratory will hold a virtual workshop June 15-16, 2022, to explore questions critical to designing and implementing pragmatic clinical trials conducted within healthcare systems. This workshop is an opportunity to glean the most salient lessons learned from an experienced group of the pragmatic trial investigators who will openly share the challenges they have encountered, solutions they have developed, and thoughts for the future.
The workshop, Critical Questions for Pragmatic Clinical Trialists: Insights From the NIH Pragmatic Trials Collaboratory’s First Decade, will take place from 1:00-5:00 p.m. ET each day, kicking off with a keynote presentation by Shannon N. Zenk, PhD, MPH, RN, FAAN, Director, National Institute of Nursing Research, National Institutes of Health, DHHS. All sessions are free and open to the public.
Register today.
See the full schedule.

NIH Pragmatic Trials Collaboratory 2022 Annual Workshop Critical Questions for Pragmatic Clinical Trialists: Insights From the NIH Pragmatic Trials Collaboratory’s First Decade
2022-06-16 13:00 - 17:00
The NIH Pragmatic Trials Collaboratory will hold a virtual workshop June 15-16, 2022, to explore questions critical to designing and implementing pragmatic clinical trials conducted within healthcare systems. This workshop is an opportunity to glean the most salient lessons learned from an experienced group of the pragmatic trial investigators who will openly share the challenges they have encountered, solutions they have developed, and thoughts for the future.
The workshop will include 4 moderated webinar discussions with panels of experts that will focus on changes and current best practices regarding the use of electronic health records for pragmatic research, considerations for pragmatic trial study design, how to optimize a 1-year planning phase for a pragmatic trial, and tips for implementing interventions in complex health systems.
All sessions are free and open to the public.
Register today.
See the full schedule.
