Grand Rounds July 18, 2025: State of Clinical Trials: An Analysis of ClinicalTrials.gov (Adrian F. Hernandez, MD, MHS; Rebecca D. Sullenger, MPH; Sara Bristol Calvert, PharmD; Karen Chiswell, PhD; Christopher J. Lindsell, PhD)
2025-07-18 13:00 - 14:00 (America/New_York)
Speakers:
Adrian F. Hernandez, MD, MHS
Executive Director
Duke Clinical Research Institute
Rebecca D. Sullenger, MPH
Duke University School of Medicine
MD Student | Class of 2026
Panelists:
Sara Bristol Calvert, PharmD
Director of Projects
Clinical Trials Transformation Initiative
Karen Chiswell, PhD
Statistical Scientist
Duke Clinical Research Institute
Christopher J. Lindsell, PhD
Director, Data Science and Biostatistics
Duke Clinical Research Institute
Title: State of Clinical Trials: An Analysis of ClinicalTrials.gov
Date: Friday, July 18, 2025, 1:00-2:00 pm ET
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Grand Rounds July 25, 2025: Initial Outcomes of the NOHARM Pragmatic Trial (Jon Tilburt, MD; Andrea Cheville, MD)
2025-07-25 13:00 - 14:00
Speakers:
Jon Tilburt, MD
Professor of Medicine
Mayo Clinic in Arizona
Andrea Cheville, MD
Professor of Physical Medicine and Rehabilitation
Mayo Clinic in Minnesota
Title: Initial Outcomes of the NOHARM Pragmatic Trial
Date: Friday, July 25, 2025, 1:00-2:00 pm ET
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Grand Rounds August 1, 2025: Clinical Trial Notifications Triggered by Artificial Intelligence–Detected Cancer Progression (Kenneth L. Kehl, MD, MPH)
2025-08-01 13:00 - 14:00
Speaker:
Kenneth L. Kehl, MD, MPH
Assistant Professor of Medicine and Physician
Dana-Farber Cancer Institute
Title: Clinical Trial Notifications Triggered by Artificial Intelligence–Detected Cancer Progression

Date: Friday, August 1, 2025, 1:00-2:00 p.m. ET
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Grand Rounds August 8, 2025: Varenicline for Youth Nicotine Vaping Cessation: A Randomized Clinical Trial (A. Eden Evins, MD, MPH)
2025-08-08 13:00 - 14:00
Speaker:
A. Eden Evins, MD, MPH
Cox Family Professor of Psychiatry, Harvard Medical School
Founding Director, MGH Center for Addiction Medicine
Director for Faculty Development, Mass General Hospital Department of Psychiatry
Title:Varenicline for Youth Nicotine Vaping Cessation: A Randomized Clinical Trial

Date: Friday, August 8, 2025, 1:00-2:00 p.m. ET
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Grand Rounds August 15, 2025: Dexmedetomidine or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial (Tim Walsh, MD, FFICM; Chris Weir, PhD; Richard Parker, MSc)
2025-08-15 13:00 - 14:00
Speakers:
Tim Walsh, MD, FFICM
Chair of Critical Care, Professor
Usher Institute
University of Edinburgh
Chris Weir, PhD
Chair of Medical Statistics, Professor
Edinburgh Clinical Trials Unit, Usher Institute
University of Edinburgh
Richard Parker, MSc
Research Fellow
Edinburgh Clinical Trials Unit, Usher Institute
University of Edinburgh
Title: Dexmedetomidine or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial

Date: Friday, August 15, 2025, 1:00-2:00 p.m. ET
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Grand Rounds August 22, 2025: The PCORnet Playbook: Avoiding the Fumble in Pragmatic Trials (Emily O'Brien, PhD, FAHA)
2025-08-22 13:00 - 14:00
Speaker:
Emily O’Brien, PhD, FAHA
Associate Professor
Duke Clinical Research Institute
Duke University School of Medicine
Department of Population Health Sciences
Title: The PCORnet Playbook: Avoiding the Fumble in Pragmatic Trials

Date: Friday, August 22, 2025, 1:00-2:00 p.m. ET
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Grand Rounds September 5, 2025: The Non-Learning Health System (Robert Califf, MD)
2025-09-05 13:00 - 14:00
Speaker:
Robert Califf, MD
Instructor in Medicine
Duke University Medical Center
Former Commissioner of Food and Drugs
Title: The Non-Learning Health System

Date: Friday, September 5, 2025, 1:00-2:00 p.m. ET
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Grand Rounds September 12, 2025: Initial Outcomes of the Optimizing Pain Treatment in Medical Settings Using Mindfulness (OPTIMUM) Pragmatic Trial (Natalia E. Morone, MD, MS; Carol M. Greco, PhD; Kim Faurot, PhD)
2025-09-12 13:00 - 14:00
Speakers:
Natalia E. Morone, MD, MS
Boston Medical Center/Boston University
Carol M. Greco, PhD
University of Pittsburgh
Kim Faurot, PhD
University of North Carolina at Chapel Hill
Title: Initial Outcomes of the Optimizing Pain Treatment in Medical Settings Using Mindfulness (OPTIMUM) Pragmatic Trial

Date: Friday, September 12, 2025, 1:00-2:00 p.m. ET
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Grand Rounds September 19, 2025: Hurdles for the Delivery of Trials: Insights From the Randomized Embedded Multifactorial Adaptive Platform Trial on Community-Acquired Pneumonia (REMAP-CAP) in Europe (Denise van Hout, MD, PhD)
2025-09-19 13:00 - 14:00
Speaker:
Denise van Hout, MD, PhD
Postdoctoral Researcher
Julius Center for Health Sciences and Primary Care
University Medical Center Utrecht, the Netherlands
Title: Hurdles for the Delivery of Trials: Insights From the Randomized Embedded Multifactorial Adaptive Platform Trial on Community-Acquired Pneumonia (REMAP-CAP) in Europe

Date: Friday, September 19, 2025, 1:00-2:00 p.m. ET
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Grand Rounds September 26, 2025: Significance in ePCTs: P Values vs Decision-Maker Perspectives (Gregory E. Simon, MD, MPH; Susan Huang, MD, MPH; Elizabeth Turner, PhD)
2025-09-26 13:00 - 14:00
Speakers:
Gregory E. Simon, MD, MPH
Kaiser Permanente Washington Health Research Institute
Susan Huang, MD, MPH
University of California Irvine
Elizabeth Turner, PhD
Duke University
Title: Significance in Pragmatic Clinical Trials: P Values vs Decision-Maker Perspectives

Date: Friday, September 26, 2025, 1:00-2:00 p.m. ET
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Grand Rounds October 3, 2025: Multi-Domain Rehabilitation for Older Patients With Myocardial Infarction: The PIpELINe Trial (Elisabetta Tonet, MD)
2025-10-03 13:00 - 14:00
Speaker:
Elisabetta Tonet, MD
Cardiology Consultant
Cardiology Unit
Azienda Ospedaliero–Universitaria di Ferrara, Italy
Title: Multi-Domain Rehabilitation for Older Patients With Myocardial Infarction: The PIpELINe Trial

Date: Friday, October 3, 2025, 1:00-2:00 p.m. ET
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Grand Rounds October 10, 2025: Engaging Rural Communities in Pragmatic Clinical Trials: Leveraging the CARE for Health Initiative Hubs to Enhance Enrollment for BeatPain (Julie M. Fritz, PhD, PT, FAPTA; Sebastian Tong, MD, MPH)
2025-10-10 13:00 - 14:00
Speakers:
Julie M. Fritz, PhD, PT, FAPTA
Distinguished Professor
Department of Physical Therapy & Athletic Training University of Utah
Sebastian Tong, MD, MPH
Associate Professor
University of Washington
Title: Engaging Rural Communities in Pragmatic Clinical Trials: Leveraging the CARE for Health Initiative Hubs to Enhance Enrollment for BeatPain
Date: Friday, October 10, 2025, 1:00-2:00 p.m. ET
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Grand Rounds October 17, 2025: Making Effective Use of Data Infrastructure in PCORnet® (Charles Bailey, MD, PhD; Keith Marsolo, PhD)
2025-10-17 13:00 - 14:00
Speakers:
Charles Bailey, MD, PhD
Department of Pediatrics
Perelman School of Medicine
University of Pennsylvania
Biomedical and Health Informatics
Children’s Hospital of Philadelphia
Keith Marsolo, PhD
Associate Professor
Department of Population Health Sciences
Duke Clinical Research Institute
Duke University School of Medicine
Title: Making Effective Use of Data Infrastructure in PCORnet®
Date: Friday, October 17, 2025, 1:00-2:00 p.m. ET
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Grand Rounds October 24, 2025: Studying Neglected Diseases: Insights from the PARACHUTE-HF Trial (Renato Lopes MD, PhD)
2025-10-24 13:00 - 14:00
Speaker:
Renato Lopes MD, PhD
Professor of Medicine, Division of Cardiology
Duke University Medical Center
Duke Clinical Research Institute
Title: Studying Neglected Diseases: Insights from the PARACHUTE-HF Trial

Date: Friday, October 24, 2025, 1:00-2:00 p.m. ET
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Grand Rounds October 31, 2025: The LHS Shared Commitments — All Treats, No Tricks (Peter Margolis, MD, PhD; Sean C. Dowdy, MD, FACS, FACOG; Sarah Greene, MPH)
2025-10-31 13:00 - 14:00
Speakers:
Peter Margolis, MD, PhD
Adjunct Professor of Pediatrics
Stanford University School of Medicine
Emeritus Professor of Pediatrics
University of Cincinnati School of Medicine
Former Co-Director of the James M. Anderson Center for Health Systems Excellence
Cincinnati Children’s Hospital Medical Center
Sean C. Dowdy, MD, FACS, FACOG
Chief Value Officer
Robert D. and Patricia E. Kern Associate Dean for Practice Transformation
Professor, Division of Gynecologic Oncology
Mayo Clinic
Sarah Greene, MPH
Consultant and Senior Advisor
The National Academy of Medicine
Title: The LHS Shared Commitments — All Treats, No Tricks
Date: Friday, October 31, 2025, 1:00-2:00 p.m. ET
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Grand Rounds November 7, 2025: EMMA – A Remote, Decentralized Clinical Trial to Evaluate the Effectiveness of a Migraine App (Daniel Pach, MD; Stefanie Lysk, MS)
2025-11-07 13:00 - 14:00
Speakers:
Daniel Pach, MD
Charité – Universitätsmedizin Berlin
Stefanie Lysk, MS
Charité – Universitätsmedizin Berlin
Newsenselab GmbH (app manufacturer)
Title: EMMA – A Remote, Decentralized Clinical Trial to Evaluate the Effectiveness of a Migraine App
Date: Friday, November 7, 2025, 1:00-2:00 p.m. ET
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Grand Rounds November 14, 2025: IMPACT-BP: A Community-Based Intervention for Sustainable Blood Pressure Control in Rural KwaZulu-Natal, South Africa (Mark Siedner, MD, MPH)
2025-11-14 13:00 - 14:00
Speaker:
Mark Siedner, MD, MPH
Professor of Medicine, Harvard Medical School
Faculty, Africa Health Research Institute
Title: IMPACT-BP: A Community-Based Intervention for Sustainable Blood Pressure Control in Rural KwaZulu-Natal, South Africa

Date: Friday, November 14, 2025, 1:00-2:00 p.m. ET
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Grand Rounds November 21, 2025: Insights Informing Strategies for Optimizing the Collection of Clinical Trial Data (Laura Galuchie, BS; Zak Smith, MA)
2025-11-21 13:00 - 14:00
Speakers:
Laura Galuchie, BS
Senior Director, Global Clinical Development
Merck & Co, Inc.
Zak Smith, MA
Assistant Director, Data Sciences & Analytics
Tufts Center for the Study of Drug Development
Tufts University School of Medicine
Title: Insights Informing Strategies for Optimizing the Collection of Clinical Trial Data
Date: Friday, November 21, 2025, 1:00-2:00 p.m. ET
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Grand Rounds December 5, 2025: Transcutaneous Electrical Nerve Stimulation Reduces Movement-Pain in People With Fibromyalgia: Results From FM-TIPS, a Cluster Randomized Pragmatic Trial (Leslie J. Crofford, MD; Dana Dailey, PT, PhD; Kathleen Sluka, PT, PhD, FAPTA)
2025-12-05 01:00 - 14:00
Speakers:
Leslie J. Crofford, MD
Wilson Family Chair in Medicine
Professor of Medicine and Pathology, Microbiology & Immunology
Vanderbilt University Medical Center
Dana Dailey PT, PhD
Assistant Research Scientist
Physical Therapy and Rehabilitation Science
University of Iowa
Kathleen Sluka, PT, PhD, FAPTA
Professor
University of Iowa
Title: Transcutaneous Electrical Nerve Stimulation Reduces Movement-Pain in People With Fibromyalgia: Results From FM-TIPS, a Cluster Randomized Pragmatic Trial

Date: Friday, December 5, 2025, 1:00-2:00 p.m. ET
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Grand Rounds December 12, 2025: From Eligibility to Enrollment Without a Clinic Visit: The Eat Well Produce Prescription Trial for Patients with Diabetes at Risk of Food Insecurity (Connor Drake, PhD, MPA; Susan Spratt, MD)
2025-12-12 13:00 - 14:00
Speakers:
Connor Drake, PhD, MPA
Research Health Scientist
Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT)
Durham VA Health System HSR&D
Assistant Professor
Department of Population Health Sciences
Duke University School of Medicine
Susan Spratt, MD
Department of Medicine
Division of Endocrinology, Metabolism, and Nutrition
Department of Family Medicine and Community Health
Duke University School of Medicine
Title: From Eligibility to Enrollment Without a Clinic Visit: The Eat Well Produce Prescription Trial for Patients with Diabetes at Risk of Food Insecurity
Date: Friday, December 12, 2025, 1:00-2:00 p.m. ET
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Grand Rounds December 19, 2025: Use of Ambient AI Scribes to Reduce Administrative Burden and Professional Burnout: Lessons Learned and Future Directions (Lee H. Schwamm, MD; Kristine Olson, MD, MSc; Daniella Meeker, PhD)
2025-12-19 13:00 - 14:00
Speakers:
Lee H. Schwamm, MD
Sr Vice President and Chief Digital Health Officer
Yale New Haven Health System
Associate Dean, Digital Strategy & Transformation
Professor of Neurology and of Biomedical Informatics and Data Sciences
Yale School of Medicine
Kristine Olson, MD, MSc
Assistant Clinical Professor
Department of Medicine
Yale School of Medicine
Daniella Meeker, PhD
Associate Professor of Biomedical Informatics and Data Science
Yale School of Medicine
Chief Research Information Officer
Yale New Haven Health System
Title: Use of Ambient AI Scribes to Reduce Administrative Burden and Professional Burnout: Lessons Learned and Future Directions
Date: Friday, December 19, 2025, 1:00-2:00 p.m. ET
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Grand Rounds January 9, 2026: Pragmatic Care Embedded Randomization: Insights From the KP-VACCINATE Megatrial (Ankeet S. Bhatt, MD, MBA, ScM)
2026-01-09 13:00 - 14:00
Speaker:
Ankeet S. Bhatt, MD, MBA, ScM
Cardiologist, Kaiser Permanente San Francisco Medical Center
Research Scientist, Kaiser Permanente Northern California Division of Research
Assistant Professor, Kaiser Permanente Bernard J. Tyson School of Medicine
Adjunct Professor, Stanford University School of Medicine
Title: Pragmatic Care Embedded Randomization: Insights From the KP-VACCINATE Megatrial

Date: Friday, January 9, 2026, 1:00-2:00 p.m. ET
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Webinar ID: 970 2299 5247
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Grand Rounds January 16, 2026: Can Financial Incentives Increase Participation in a Memory Concerns Registry? (Mireille Jacobson, PhD)
2026-01-16 13:00 - 14:00
Speaker:
Mireille Jacobson, PhD
Professor, University of Southern California Davis
School of Gerontology and Schaeffer Institute
Title: Can Financial Incentives Increase Participation in a Memory Concerns Registry?

Date: Friday, January 16, 2026, 1:00-2:00 p.m. ET
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Webinar ID: 951 5543 3564
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Grand Rounds January 23, 2026: DASH Groceries to Stop Hypertension: Results From the GoFresh Trial (Stephen P. Juraschek, MD, PhD, FAHA, AHSCP-CHS)
2026-01-23 13:00 - 14:00
Speaker:
Stephen P. Juraschek, MD, PhD, FAHA, AHSCP-CHS
Associate Professor of Medicine
HCA Hypertension Center Director & Beth Israel Deaconess Medical Center
Title: DASH Groceries to Stop Hypertension: Results From the GoFresh Trial

Date: Friday, January 23, 2026, 1:00-2:00 p.m. ET
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International numbers available: https://duke.zoom.us/u/ahdAZAvu5
Webinar ID: 914 8692 2120
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Grand Rounds January 30, 2026: A Pragmatic Randomized Controlled Trial of Ambient Artificial Intelligence to Improve Health Practitioner Well-Being (Majid Afshar, MD, MS; Mary Ryan Baumann, PhD)
2026-01-30 13:00 - 14:00
Speakers:
Majid Afshar, MD, MS
Associate Professor
Director, Learning Health Systems
Departments of Medicine and Biostatistics & Medical Informatics
University of Wisconsin-Madison
Mary Ryan Baumann, PhD
Assistant Professor
Departments of Population Health Sciences and Biostatistics & Medical Informatics
University of Wisconsin-Madison
Title: A Pragmatic Randomized Controlled Trial of Ambient Artificial Intelligence to Improve Health Practitioner Well-Being
Date: Friday, January 30, 2026, 1:00-2:00 p.m. ET
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International numbers available: https://duke.zoom.us/u/aebRZGrmJR
Webinar ID: 913 2623 1433
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Grand Rounds February 6, 2026: Spinal Manipulation and Clinician-Supported Biopsychosocial Self-Management for Acute Back Pain: The PACBACK Randomized Clinical Trial (Gert Bronfort, DC, PhD; Brent Leininger, DC, MS, PhD)
2026-02-06 13:00 - 14:00
Join the webinar: https://duke.zoom.us/j/98476157601?pwd=[REDACTED]
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Title: Spinal Manipulation and Clinician-Supported Biopsychosocial Self-Management for Acute Back Pain: The PACBACK Randomized Clinical Trial
Speakers:
Gert Bronfort, DC, PhD
Research Professor
Integrative Health & Wellbeing Research Program
University of Minnesota
Brent Leininger, DC, MS, PhD
Associate Professor
Integrative Health & Wellbeing Research Program
University of Minnesota
Date: Friday, February 6, 2026, 1:00-2:00 p.m. ET
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Webinar ID: 984 7615 7601
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Grand Rounds February 13, 2026: The Making of the PCORnet® COMPARE-Pediatric IBD Study (Michael D. Kappelman, MD, MPH)
2026-02-13 13:00 - 14:00
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Title: The Making of the PCORnet® COMPARE-Pediatric IBD Study
Speaker:
Michael D. Kappelman, MD, MPH
Professor, Pediatric Gastroenterology
University of North Carolina at Chapel Hill
Date: Friday, February 13, 2026, 1:00-2:00 p.m. ET
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Webinar ID: 985 0489 3560
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Grand Rounds February 20, 2026: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention (RAMP): Early Progress and Lessons Learned (Diana Burgess, PhD; Roni Evans, DC, MS, PhD; Katie Hadlandsmyth, PhD)
2026-02-20 13:00 - 14:00
Join the webinar: https://duke.zoom.us/j/93501751057?pwd=[REDACTED]
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Title: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention (RAMP): Early Progress and Lessons Learned
Speakers:
Diana Burgess, PhD
Professor of Medicine,
University of Minnesota
Director, VA Advanced Fellowship Program in Health Systems Research, Center for Care Delivery and Outcomes Research (CCDOR),
Minneapolis Veterans Affairs Healthcare System
Director, QUERI Complementary and Integrative Health Evaluation Center (CIHEC),
Veterans Affairs Healthcare System
Roni Evans, DC, MS, PhD
Research Professor
Director, Integrative Health & Wellbeing Research Program
Earl E. Bakken Center for Spirituality & Healing,
University of Minnesota
Katie Hadlandsmyth, PhD
Associate Professor
College of Nursing
University of Iowa
Date: Friday, January 20, 2026, 1:00-2:00 p.m. ET
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International numbers available: https://duke.zoom.us/u/adObz218II
Webinar ID: 935 0175 1057
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Grand Rounds February 27, 2026: Optimal Transfusion Strategy in High Cardiac Risk Patients After Major Surgery: Results of the TOP Trial (Panos Kougias, MD, MSc; Sherene Sharath, PhD, MPH)
2026-02-27 13:00 - 14:00
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Title: Optimal Transfusion Strategy in High Cardiac Risk Patients After Major Surgery: Results of the TOP Trial
Speakers:
Panos Kougias, MD, MSc
Professor and Chair
Department of Surgery, SUNY Downstate Health Sciences University
Sherene Sharath, PhD, MPH
Assistant Professor
Department of Surgery, SUNY Downstate Health Sciences University
Date: Friday, February 27, 2026, 1:00-2:00 p.m. ET
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Webinar ID: 995 3126 9455
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Grand Rounds March 6, 2026: Bringing Primary Care Clinical Trials Research Into the 21st Century: Lessons Learned and Developments From Large-Scale European Adaptive Platform Trials of Therapeutics for Acute Respiratory Infections (Christopher C. Butler, BA, MBChB, DCH, CCH, MD, FRCGP)
2026-03-06 13:00 - 14:00
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Title: Bringing Primary Care Clinical Trials Research Into the 21st Century: Lessons Learned and Developments From Large-Scale European Adaptive Platform Trials of Therapeutics for Acute Respiratory Infections
Speaker:
Christopher C. Butler, BA, MBChB, DCH, CCH, MD, FRCGP
Associate Head for Research
Professor of Primary Care
Professorial Fellow, Trinity College
Clinical Director, Primary Care Clinical Trials Unit
University of Oxford
Date: Friday, March 6, 2026, 1:00-2:00 p.m. ET
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Webinar ID: 943 1923 6794
Passcode: [REDACTED]
