Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials
Welcome to the Living Textbook of pragmatic clinical trials, a collection of knowledge from the NIH Pragmatic Trials Collaboratory. Pragmatic clinical trials present an opportunity to efficiently generate high-quality evidence to inform medical decision-making. However, these trials pose different challenges than traditional clinical trials. The Living Textbook reflects a collection of special considerations and best practices in the design, conduct, and reporting of pragmatic clinical trials.
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What is the
NIH Pragmatic Trials Collaboratory?
What is a
pragmatic clinical trial?
Training Resources
Featured
Registration Opens for Pragmatic Trials Workshop at SCT 45th Annual Meeting
The NIH Pragmatic Trials Collaboratory will offer a preconference workshop at the 45th Annual Meeting of the Society for Clinical Trials in Boston titled “Patient-Centered Research in Real-World Settings: Essentials of Embedded Pragmatic Clinical Trials.” Registration for the workshop is now open.
NIH Pragmatic Trials Collaboratory Launches New Online Training Resources
Check out the new training resources page, featuring a video library, learning modules, and workshop archives. Take a tour of the enhanced training resources webpages we built to help researchers learn about pragmatic trials.
NIH COLLABORATORY TRIALS
Pragmatic clinical trials that address questions of major public health importance and provide proof of concept for innovative pragmatic research designs.
CORES
Working groups that support the conduct of NIH Collaboratory Trials and generate guidance addressing implementation challenges.
DISTRIBUTED RESEARCH NETWORK
Network enabling investigators to collaborate in the use of electronic health data while safeguarding protected health information.
Upcoming Learning Opportunities
Grand Rounds April 19, 2024: The Yale Open Data Access (YODA) Project: 10 Years of Clinical Trial Data Sharing (Joseph S. Ross, MD, MHS)
April 19 @ 1:00 pm - 2:00 pmGrand Rounds April 26, 2024: Waiver or Alteration of Informed Consent for Minimal Risk Clinical Investigations – FDA Regulation Development and Research Landscape (Lauren Milner, PhD; Jonathan Casey, MD, MSCI; Matthew Semler, MD, MSCI)
April 26 @ 1:00 pm - 2:00 pmGrand Rounds May 3, 2024: Comparative Effectiveness of Kidney Stone Surgery in Pediatric Patients: The PKIDS Trial (Gregory Tasian, MD, MSc, MSCE)
May 3 @ 1:00 pm - 2:00 pm
NEWS
- April 18, 2024: New Living Textbook Chapter Articulates How Investigators Navigated Unexpected Challenges During Pragmatic Clinical TrialsDuring the course of the years-long pragmatic clinical trials supported by the NIH Pragmatic Trials Collaboratory, many unanticipated challenges have occurred, some of which have had profound effects on usual ...
- April 17, 2024: In This Week’s PCT Grand Rounds, 10 Years of the YODA ProjectIn this Friday’s PCT Grand Rounds, Joseph Ross of Yale University will present “The Yale Open Data Access (YODA) Project: 10 Years of Clinical Trial Data Sharing.” The Grand Rounds session ...
- April 10, 2024: Primary Results of PRIM-ER Trial to Be Featured in This Week’s PCT Grand RoundsIn this Friday’s PCT Grand Rounds, Corita Grudzen of the Memorial Sloan Kettering Cancer Center will present “Primary Palliative Care for Emergency Medicine, a Cluster Randomized Stepped-Wedge Trial Across 33 ...