A workshop focused on the inclusion of diverse participants in pragmatic clinical trials with insights about planning for diversity, engaging participants, learning from implementation science to maximize diversity, and developing a pipeline of diverse investigators
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ePCT Workshop: Health Care Systems Research Network
ePCT Workshop: Health Care Systems Research Network (Virtual, May 2021)
A workshop on the essentials of embedded PCTs (ePCTs) with a focus on methods relevant to health services researchers
Disseminating, Implementing, and Sustaining Evidence-Based Practices into Clinical Care: NIH-Hosted Workshop
Best practices for dissemination, implementation, and sustainability of ePCT findings
ePCTs of Therapeutic A vs. B Interventions: NIH-Hosted Workshop
ePCTs of Therapeutic A vs. B Interventions: NIH-Hosted Workshop (May 2018)
Explores challenges and strategies for planning and implementing ePCTs that compare two or more therapeutic medical regimens. Design and Analysis of ePCTs: NIH-Hosted Workshop
Design and Analysis of ePCTs: NIH-Hosted Workshop
Design and Analysis of ePCTs: NIH-Hosted Workshop (May 2019)
Panel discussions of challenges in the design and analysis of ePCTs
Advances at the Intersection of Digital Health, EHRs, and PCTs: NIH-Hosted Workshop
Advances at the Intersection of Digital Health, EHRs, and PCTs: NIH-Hosted Workshop (May-July 2020)
A workshop series highlighting advances in digital health, new approaches and evolving standards for EHRs, and implications for researchers conducting PCTs
Ethical and Regulatory Issues of Pragmatic Clinical Trials: NIH-Hosted Workshop
Ethical and Regulatory Issues of Pragmatic Clinical Trials: NIH-Hosted Workshop
Unique ethical and regulatory issues identified by the NIH Collaboratory Trials supported by the NIH Collaboratory
EHR Workshop Video Modules
EHR Video Modules
This selection of short educational videos is drawn from our 2020 EHR Workshop Grand Rounds Series, “Advances at the Intersection of Digital Health, Electronic Health Records and Pragmatic Clinical Trials.” The series highlighted advances in digital health, new approaches and evolving standards for electronic health records (EHRs), and implications for researchers conducting pragmatic trials.
Living Textbook Video Modules
Living Textbook Video Modules
This selection of short educational videos is drawn from our 2020 Living Textbook Grand Rounds Series. The series focused on the Living Textbook and featured expert speakers guiding the audience through the life cycle of an embedded pragmatic clinical trial—from idea to funding to implementation.
| Module | Description |
| What Are Pragmatic Clinical Trials? (4:51) | NIH Collaboratory investigator Dr. Lesley Curtis answers the question, "What do we mean when we talk about 'pragmatic clinical trials'?" |
| Designing Pragmatic Trials That Are Fit for Purpose (9:14) | NIH Collaboratory investigator Dr. Lesley Curtis uses the PRECIS-2 wheel to summarize important considerations in designing pragmatic clinical trials that are fit for purpose. |
| Engaging With Stakeholders in Pragmatic Clinical Trials (10:35) | NIH Collaboratory investigator Dr. Greg Simon discusses the importance of building partnerships and engaging with stakeholders throughout the life cycle of a pragmatic clinical trial. |
| Building a Study Team for a Pragmatic Clinical Trial (6:12) | NIH Collaboratory investigator Dr. Lesley Curtis shares tips for building effective study teams for pragmatic clinical trials. |
| Designing With Implementation in Mind (16:58) | NIH Collaboratory researchers Leah Tuzzio and Dr. Vince Mor discuss what it means to design a pragmatic trial with implementation in mind, and they share examples from 2 of the NIH Collaboratory Trials—ABATE Infection and PROVEN. |
| Pilot and Feasibility Testing: The LIRE Example (18:10) | NIH Collaboratory investigator Dr. Jerry Jarvik, principal investigator of the LIRE NIH Collaboratory Trial, discusses pilot and feasibility testing in pragmatic clinical trials. |
| Is a Pragmatic Trial Right for Your Research Question? (3:55) | Dr. Wendy Weber, the NIH project officer for the NIH Collaboratory, poses a fundamental question: Is a pragmatic clinical trial the right approach for your research question? |
| Finding the Right NIH Funding Opportunity (13:08) | Dr. Wendy Weber, the NIH project officer for the NIH Collaboratory, shares tips for finding the right NIH funding opportunity and program official for your grant application. |
| Writing a Successful Grant Application (14:08) | Dr. Wendy Weber, the NIH project officer for the NIH Collaboratory, offers advice for writing a successful grant application for a pragmatic clinical trial, including common pitfalls and application dos and don’ts. |
| Choosing the Right Study Design (18:34) | NIH Collaboratory investigator Dr. Liz Turner offers insights into choosing the right design for a pragmatic clinical trial, using examples from the NIH Collaboratory Trials. |
| Understanding Clustering in Cluster Randomized Trials (16:54) | NIH Collaboratory investigator Dr. Liz Turner explains outcome clustering in cluster randomized trials and how to account for it. |
| Choosing Endpoints and Outcomes in Pragmatic Clinical Trials (7:26) | NIH Collaboratory researcher Dr. Devon Check summarizes key questions for choosing endpoints and outcomes in pragmatic clinical trials. |
| Defining Outcomes With Electronic Health Record Data (7:09) | NIH Collaboratory researcher Dr. Rachel Richesson addresses the complexities of using electronic health record data to define outcomes in pragmatic clinical trials. |
| Assessing Data Quality (8:43) | NIH Collaboratory researcher Dr. Rachel Richesson discusses the importance of assessing data quality when using electronic health record data in pragmatic clinical trials. |
Quick Start Guides
Quick Start Guides
Sign up to receive the The NIH Collaboratory Quick Start Guides. These guides are designed for clinical investigators interested in learning how to conduct embedded pragmatic clinical trials (ePCTs) and successfully partner with health care systems leaders.