Podcast December 5: Validating a Computable Phenotype: Should Results Change a Trial’s Pre-Specified Primary Outcome? (Gregory E. Simon, MD, MPH, Susan M. Shortreed, PhD)

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Lesley Curtis speaks with Dr. Gregory Simon and Dr. Susan Shortreed of the Kaiser Permanente Washington Health Research Institute. In their conversation, Drs. Curtis, Simon, and Shortreed discuss computable phenotypes and if results should change a trial’s pre-specified primary outcome. Drs. Simon and Shortreed explain how they used the Suicide Prevention Outreach Trial (SPOT) to explore this question, the process they followed, and the lessons learned.

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Want to hear more from Dr. Gregory Simon and Dr. Susan Shortreed? View the full Grand Rounds presentation.

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Podcast November 20: Data Linkage Within, Across, and Beyond PCORnet (Thomas W. Carton, PhD, MS, Keith Marsolo, PhD)

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Lesley Curtis speaks with Dr. Tom Carton, of the REACHnet Clinical Data Research Network, and Dr. Keith Marsolo, of the Duke School of Medicine, regarding data linkage within, beyond, and across The National Patient-Centered Clinical Research Network (PCORnet). In their conversation with Dr. Curtis, Drs. Carton and Marsolo discuss the data linkage problem their trying to solve, specific steps taken, their developed action plan, and the associated challenges.

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Want to hear more from Renee Mitchell, Terrie Reed, and Roseann White? View the full Grand Rounds presentation.

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Podcast November 7, 2018: MDEpiNet RAPID and SPEED Projects: Leveraging Real World Evidence to Get Better, Faster, Cheaper Medical Devices for Physicians and Patients (Renee Mitchell, MT, CLS, Terrie Reed, MSIE, Roseann White, MA)

In this episode of the NIH Collaboratory Grand Rounds podcast, Renee Mitchell, Terrie Reed, and Roseann White discuss the MDEpiNet RAPID and SPEED Projects. In their conversation with Dr. Adrian Hernandez, Renee, Terrie, and Roseann discuss the concept behind the projects, the collaborative nature, associated challenges, next phases, and the future.

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Want to hear more from Renee Mitchell, Terrie Reed, and Roseann White? View the full Grand Rounds presentation.

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Podcast October 1, 2018: Returning Individual Research Results to Participants: Guidance for a New Research Paradigm (Jeffrey Botkin, MD, MPH, Consuelo Wilkins, MD, MSCI)

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Jeffrey Botkin and Dr. Consuelo Wilkins discuss returning individual research results to participants. In their conversation with Dr. Adrian Hernandez, Drs. Botkin and Wilkins emphasize the importance of returning results to participants, the present challenges, and hopes for the process in the next five years.

For more information, view the NASEM consensus report.

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Want to hear more from Drs. Botkin and Wilkins? View the full Grand Rounds presentation.

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Podcast August 7, 2018: A Digital Pragmatic Direct-to-Participant Clinical Trial for Identifying Underdiagnosed Atrial Fibrillation in a Large Health Plan Population (Steven Steinhubl, MD)

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Steven Steinhubl discusses a digital and pragmatic clinical trial, mSToPS, that explores underdiagnosed atrial fibrillation in a large health plan population. In his conversation with Dr. Lesley Curtis, Dr. Steinhubl discusses what lessons were learned through the study, what he found most surprising, and the role that patient engagement played.

Read more about mStops in a recent JAMA article.

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Want to hear more from Dr. Steinhubl? View the full Grand Rounds presentation.

Tune in for our next episode with Grand Rounds speakers Dr. Jeffrey Botkin and Dr. Consuelo Wilkins and their presentation “Returning Individual Research Results to Participants: Guidance for a New Research Paradigm” which will be posted the week of September 24.  

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Podcast July 17, 2018: Clinical Trial Participants’ Views of the Risks and Benefits of Data Sharing (Michelle Mello, JD, PhD)

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Michelle Mello discusses a study she and Dr. Steven Goodman recently conducted to determine how clinical trial participants think about having their participant-level data widely shared. In her discussion with Dr. Lesley Curtis, Dr. Mello discusses study results, what she found most surprising, and how the study revealed takeaways for researchers and clinical trial sponsors.

Study results are published in “Clinical Trial Participants’ Views of the Risks and Benefits of Data Sharing” in the New England Journal of Medicine.

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Want to hear more from Dr. Mello? View the full Grand Rounds presentation.

Tune in for our next episode with Grand Rounds speaker Dr. Steven Steinhubl and his presentation “A Digital Pragmatic Direct-to-Participant Clinical Trial for Identifying Underdiagnosed Atrial Fibrillation in a Large Health Plan Population” which will be posted the week of August 6. 

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Podcast July 3, 2018: Policy & Priorities: Rethinking University Research with State Data (Aaron McKethan, PhD)

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Aaron McKethan discusses the idea of rethinking research with state-level data. Dr. McKethan serves as a faculty member in the Department of Population Health Sciences at Duke University and is the Chief Data and Analytics Officer for the NC Department of Health and Human Services. With his unique perspective, Dr. McKethan provides insight into how universities and local governments can best work together to improve data quality, reduce inefficiencies, and improve collaborations.

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Want to hear more from Dr. McKethan? View the full Grand Rounds presentation.

Tune in for our next episode with Grand Rounds speaker Dr. Michelle Mello and her presentation “Clinical Trial Participants’ Views of the Risks and Benefits of Data Sharing” which will be posted the week of July 16.

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Podcast June 22, 2018: Research at Scale – Exploring What is Possible with High-Quality Real-World Data. Examples from Flatiron Health. (Amy Abernethy, MD, PhD)

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Amy Abernethy discusses research at scale, with examples from Flatiron Health. In her discussion with moderator Adrian Hernandez, Dr. Abernethy focuses on the goals of Flatiron Health, approaches for building data-sets and underlying infrastructure, what’s next on the horizon for Flatiron Health, and more.

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Want to hear more from Dr. Abernethy? View the full Grand Rounds presentation.

Tune in for our next episode with Grand Rounds speaker Dr. Aaron McKethan and his presentation “Policy & Priorities: Rethinking University Research with State Data” which will be posted the week of July 2.

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Podcast May 23, 2018: Launching the NESTcc Data Network to Improve the use of Real-World Evidence in the Medical Device Ecosystem (Rachael Fleurence, PhD)

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Rachael Fleurence, Executive Director of the National Evaluation System for health Technology Coordinating Center (NESTcc) and the Medical Device Innovation Consortium (MDIC), discusses the mission, challenges, and long term goals of NESTcc with moderator Dr. Adrian Hernandez. Rachael describes how NESTcc is working to accelerate the development and translation of new and safe health technologies, and explains where she hopes the program will be in the next three years. 

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Want to hear more from Dr. Fleurence? View the full Grand Rounds presentation.

Tune in for our next episode with Grand Rounds speaker Dr. Amy Abernathy and her presentation “Research at Scale – Exploring What is Possible with High-Quality Real-World Data. Examples from Flatiron Health” which will be posted the week of June 25.

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Podcast April 17, 2018: OHDSI: Drawing Reproducible Conclusions From Observational Clinical Data (George Hripcsak, MD, MS)

George Hripcsak

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. George Hripcsak, Chair of the Bioinformatics Department at Columbia University, discusses the Observational Health Data Sciences and Informatics (OHDSI) Program with moderator Dr. Adrian Hernandez. He describes the program’s vision to create accessible and reliable clinical evidence by analyzing the clinical data of millions of patients globally. Dr. Hripcsak also talks about how listeners can “Join the Journey” and become part of the OHDSI research network, helping to generate high-quality evidence needed to inform medical decision-making.

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Want to hear more from Dr. Hripcsak? View the full Grand Rounds presentation.

Tune in for our next episode with Grand Rounds speaker Dr. Rachael Fleurence and her presentation “Launching the NESTcc Data Network to Improve the Use of Real-World Evidence in the Medical Device Ecosystem,” which will be posted the week of May 14.

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