Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials
Welcome to the Living Textbook of pragmatic clinical trials, a collection of knowledge from the NIH Pragmatic Trials Collaboratory. Pragmatic clinical trials present an opportunity to efficiently generate high-quality evidence to inform medical decision-making. However, these trials pose different challenges than traditional clinical trials. The Living Textbook reflects a collection of special considerations and best practices in the design, conduct, and reporting of pragmatic clinical trials.
Get Started
What is the
NIH Pragmatic Trials Collaboratory?
What is a
pragmatic clinical trial?
Training Resources
Featured
Registration Opens for Pragmatic Trials Workshop at SCT 45th Annual Meeting
The NIH Pragmatic Trials Collaboratory will offer a preconference workshop at the 45th Annual Meeting of the Society for Clinical Trials in Boston titled “Patient-Centered Research in Real-World Settings: Essentials of Embedded Pragmatic Clinical Trials.” Registration for the workshop is now open.
NIH Pragmatic Trials Collaboratory Launches New Online Training Resources
Check out the new training resources page, featuring a video library, learning modules, and workshop archives. Take a tour of the enhanced training resources webpages we built to help researchers learn about pragmatic trials.
NIH COLLABORATORY TRIALS
Pragmatic clinical trials that address questions of major public health importance and provide proof of concept for innovative pragmatic research designs.
CORES
Working groups that support the conduct of NIH Collaboratory Trials and generate guidance addressing implementation challenges.
DISTRIBUTED RESEARCH NETWORK
Network enabling investigators to collaborate in the use of electronic health data while safeguarding protected health information.
Upcoming Learning Opportunities
Mind the Gap Webinar Series: Deconstruction of the Type 2 Hybrid Effectiveness-Implementation Study Design that Uses Two Randomized Controlled Trials
March 20 @ 12:00 pm - 1:00 pmGrand Rounds March 22, 2024: Early Diagnosis and Assessment of Autism Via Objective Measurements of Social Visual Engagement (Warren Jones, PhD)
March 22 @ 1:00 pm - 2:00 pmPrevention in Focus Webinar Series: Is It More than PMS? Learn About PMDD
March 27 @ 1:00 pm - 2:00 pmGrand Rounds March 29, 2024: Effect Of A Multicomponent Intervention to Improve Patient Access to Kidney Transplant and Living Kidney Donation: A Pragmatic, Cluster-Randomized Trial (Amit Garg, MD, MA, FRCPC, FACP, PhD; Stephanie N. Dixon, PhD, MSc)
March 29 @ 1:00 pm - 2:00 pm
NEWS
- March 14, 2024: IMPACT Collaboratory Announces New Statistical Tools for Pragmatic TrialsThe NIA IMPACT Collaboratory, a program to advance pragmatic clinical trials of interventions for people living with dementia and their care partners, announced a new collection of statistical tools for ...
- March 13, 2024: In This Friday’s PCT Grand Rounds, a Pragmatic Trial of Antibiotic Choice on Renal OutcomesIn this Friday’s PCT Grand Rounds, Edward Qian of Vanderbilt University will present “The Effect of Antibiotic Choice on Renal Outcomes: The ACORN Trial.” The Grand Rounds session will be held ...
- March 7, 2024: New Report Sets Out Posttrial Responsibilities in Pragmatic Clinical TrialsIn a new report from the NIH Pragmatic Trials Collaboratory, a team of bioethicists and implementation scientists argue for a “presumptive default” that the results of pragmatic clinical trials should ...