NIH Collaboratory Rethinking Clinical Trials – The Living Textbook

Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials

Welcome to the Living Textbook of pragmatic clinical trials, a collection of knowledge from the NIH Pragmatic Trials Collaboratory. Pragmatic clinical trials present an opportunity to efficiently generate high-quality evidence to inform medical decision-making. However, these trials pose different challenges than traditional clinical trials. The Living Textbook reflects a collection of special considerations and best practices in the design, conduct, and reporting of pragmatic clinical trials.

NIH Collaboratory

NIH COLLABORATORY TRIALS

Pragmatic clinical trials that address questions of major public health importance and provide proof of concept for innovative pragmatic research designs.

CORES

Working groups that support the conduct of NIH Collaboratory Trials and generate guidance addressing implementation challenges.

DISTRIBUTED RESEARCH NETWORK

Network enabling investigators to collaborate in the use of electronic health data while safeguarding protected health information.

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Promoting PRAGMATIC RESEARCH to increase the availability of high-quality medical evidence and IMPROVE patient care.

Citation:

NIH Collaboratory Rethinking Clinical Trials – The Living Textbook: NIH Collaboratory Rethinking Clinical Trials – The Living Textbook. In: Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials. Bethesda, MD: NIH Pragmatic Trials Collaboratory. Available at: https://rethinkingclinicaltrials.org/. Updated March 5, 2024.