Podcast April 17, 2018: OHDSI: Drawing Reproducible Conclusions From Observational Clinical Data (George Hripcsak, MD, MS)

George Hripcsak

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. George Hripcsak, Chair of the Bioinformatics Department at Columbia University, discusses the Observational Health Data Sciences and Informatics (OHDSI) Program with moderator Dr. Adrian Hernandez. He describes the program’s vision to create accessible and reliable clinical evidence by analyzing the clinical data of millions of patients globally. Dr. Hripcsak also talks about how listeners can “Join the Journey” and become part of the OHDSI research network, helping to generate high-quality evidence needed to inform medical decision-making.

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Want to hear more from Dr. Hripcsak? View the full Grand Rounds presentation.

Tune in for our next episode with Grand Rounds speaker Dr. Rachael Fleurence and her presentation “Launching the NESTcc Data Network to Improve the Use of Real-World Evidence in the Medical Device Ecosystem,” which will be posted the week of May 14.

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Podcast April 9, 2018: Data Science in the Era of Data Ubiquity (Robert Califf, MD)

In this episode of the NIH Collaboratory Grand Rounds podcast, moderator Dr. Adrian Hernandez speaks with former FDA Commissioner and current Duke Forge Director Dr. Robert Califf about the opportunities and challenges for data science in an era where data are everywhere. Now that mobile phones and other portable electronic devices provide people with access to large amounts of data day or night, Dr. Califf addresses how researchers and health systems can ensure that accurate health information is reaching these audiences.  He shares his hope that technology and access to health resources will help to bridge gaps in health related to geography, race, and educational background, allowing all Americans to lead healthier lives.

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Want to hear more from Dr. Califf? View the full Grand Rounds presentation.

Tune in for our next episode with Grand Rounds speaker Dr. George Hripcsak and his presentation “OHDSI: Drawing Reproducible Conclusions from Observational Clinical Data,” which will be posted the week of April 16.

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Podcast March 22, 2018: Straight from the Source: Clinicians’ Views on Participating in CER/PCOR (Sean Tunis, MD, MSc; Ellen Tambor, MA)

Sean TunisEllen Tambor

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Sean Tunis and Ellen Tambor of the Center for Medical Technology Policy (CMTP) speak with moderator Dr. Kevin Weinfurt about their findings on clinician attitudes on comparative effective research (CER) and patient-centered outcomes research (PCOR). The speakers discuss their findings on clinician attitudes towards research participation, and how and when to best engage them. They describe the need for involving clinicians in the planning of study design, and in closing feedback loops after studies are completed, in order to build clinicians’ trust that research does lead to quality improvement for their patients.

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Want to hear more from Sean Tunis and Ellen Tambor, and their colleague Rachael Moloney? View the full Grand Rounds presentation.

Tune in for our next episode with Grand Rounds speaker Dr. Robert Califf and his presentation “Data Science in the Era of Data Ubiquity,” which will be posted the week of April 2.

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Podcast February 16, 2018: Considerations for the Return of Genomic Results (Andrew Faucett, MS, LGC)

Dr. Andrew Faucett

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Andrew Faucett of Geisinger speaks with moderator Dr. Lesley Curtis about the return of genomic results. A key consideration for returning results of this type of research to patients and clinicians is how to scale it, as there can be issues with technical validity and sample identity in genetic variants. He describes the need to appropriately define what we can and cannot interpret from the information, and do a better job of making tools for patient use of raw data. 

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Want to hear more from Dr. Faucett and his colleague, Dr. Heidi Rehm? View the full Grand Rounds presentation.

We encourage you to share this podcast with your colleagues and tune in for our next episode with Grand Rounds speakers Drs. Sean Tunis and Ellen Tambor and their presentation “Straight from the Source: Clinicians’ Views on Participating in CER/PCOR,” which will be posted the week of March 26.

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Podcast December 8, 2017: Data and Safety Monitoring in Pragmatic Clinical Trials (Greg Simon, MD, MPH, and Susan Ellenberg, PhD)

Dr. Greg Simon Dr. Susan Ellenberg

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Greg Simon, principal investigator of the Suicide Prevention Outreach Trial (SPOT), and Susan Ellenberg, a member of the Collaboratory Regulatory/Ethics Core, speak with moderator Dr. Adrian Hernandez about the factors that determine the need for a Data and Safety Monitoring Board (DSMB) in pragmatic trials.

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Want to hear more from Drs. Simon and Ellenberg, with their colleague Dr. Sugarman? View the full Grand Rounds presentation. 

We encourage you to share this podcast with your colleagues and tune in for our next episode with Grand Rounds speakers Drs. Richard Platt and Christopher Granger, who will discuss “IMPACT-AFib: An 80,000 person Randomized Trial Using the Sentinel Initiative Platform.”

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Podcast November 14, 2017: Moderators’ Edition: Discussion of the Future of the NIH Collaboratory

Dr. Adrian Hernandez

Dr. Kevin Weinfurt

In this episode of the NIH Collaboratory Grand Rounds podcast, Drs. Adrian Hernandez and Kevin Weinfurt, two NIH Collaboratory Co-PIs and podcast moderators, discuss their predictions and hopes for the NIH Collaboratory in the next year.

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We encourage you to share this podcast with your colleagues and tune in for our next edition with Dr. Susan Ellenberg on “Data and Safety Monitoring in Pragmatic Clinical Trials.”

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Podcast October 27, 2017: Bringing Machine Learning to the Point of Care to Improve Suicide Prevention (Greg Simon, MD, MPH)

Dr. Greg Simon

In this episode of the NIH Collaboratory Grand Rounds podcast, Dr. Greg Simon of the Kaiser Permanente Washington Health Research Institute speaks with the NIH Collaboratory’s Dr. Lesley Curtis about the integration of machine learning into suicide prevention.

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Want to hear more from Dr. Simon and his colleagues? View the full Grand Rounds presentation.

Read the transcript here.

We encourage you to share this podcast with your colleagues and tune in for our special “Moderators’ Edition” episode of the podcast with Grand Rounds moderators Dr. Adrian Hernandez and Dr. Kevin Weinfurt.  It will be posted the week of November 13th.

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Podcast October 6, 2017: Health Is More Than Healthcare (Karen DeSalvo, MD, MPH, MSc)

Dr. Karen DeSalvo

In this second episode of the NIH Collaboratory Grand Rounds podcast, Dr. Karen DeSalvo, former acting Assistant Secretary for Health and Human Services, speaks with the NIH Collaboratory’s Dr. Kevin Weinfurt about the factors other than healthcare systems than impact the health of our communities.

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Want to hear more from Dr. DeSalvo? View the full Grand Rounds presentation. 

We encourage you to share this podcast with your colleagues and tune in for our next episode with Grand Rounds speakers Drs. Greg Simon, Susan Shortreed, and Don Mordecai, who will discuss “Bringing Machine Learning to the Point of Care to Improve Suicide Prevention.”

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Podcast September 29, 2017: Preprints: What, Why Not, and How (Harlan Krumholz, MD)

Dr. Harlan Krumholz

In this first episode of the NIH Collaboratory Grand Rounds podcast, Dr. Harlan Krumholz of Yale University Medical Center speaks with the NIH Collaboratory’s Dr. Adrian Hernandez about the ways preprint servers can help accelerate scientific progress through greater access to research results.

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Want to hear more from Dr. Krumholz? View the full Grand Rounds presentation. 

We encourage you to share this podcast with your colleagues and tune in for our next episode with Grand Rounds speaker Dr. Karen DeSalvo, who will discuss “Health Is More Than Healthcare.”

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August 11, 2017: Embedding Clinical Trials Into Care Delivery: The Vanderbilt Experience

Speaker

Gordon R. Bernard, MD, Melinda Owen Bass Professor of Medicine, Executive Vice President for Research, and Director, Vanderbilt Institute for Clinical and Translational Research at the Vanderbilt University Medical Center

Topic

Embedding Clinical Trials Into Care Delivery: The Vanderbilt Experience

Keywords

Pragmatic clinical trials; CTSA; Clinical and Translational Science Award; Learning healthcare system; Translational science; Study design

Key Points

  • Vanderbilt’s CTSA program serves as a reusable platform to foster a learning healthcare system. The platform consists of study-specific tailoring for protocol customization and endpoint selection, as well as a reusable fixed infrastructure for institutional and regulatory policy, master protocols, clinical decision support, clinical registries, real-time EHR data capture, expert cores, and a standing data and safety monitoring board.
  • In a learning healthcare system, clinical operations are integrated with clinical research to support research endeavors that answer real-world questions in clinical settings. Novel study structures permit informatics-enhanced interventions and data collection.

Discussion Themes

Are there data to demonstrate the “value” of combining learning (research) with operations?

How do you present the idea of having a partnership between research and clinical care to the hospital? How do you get buy-in?

Is there concern that you will stifle evolving technologies that would work if done after a year or two of learning how to do it?

Prioritize study questions by evaluating how quickly it will take to get an answer, how important the question is, or whether there will be clear benefit to patient outcomes.

For More Information

Read more about Vanderbilt’s CTSA program at https://victr.vanderbilt.edu/pub/vuctsa/index.html.

Tags
#pctGR, #LearningHealthSystem
@PCTGrandRounds, @Collaboratory1, @PCORnetwork