Archived Grand Rounds
For a searchable database of all archived Grand Rounds, see the NIH Collaboratory's Knowledge Repository.
2024 Grand Rounds Archive
- Grand Rounds April 5, 2024: A New Look at P Values for Randomized Clinical Trials (Erik van Zwet, PhD)
- Grand Rounds March 29, 2024: Effect Of A Multicomponent Intervention to Improve Patient Access to Kidney Transplant and Living Kidney Donation: A Pragmatic, Cluster-Randomized Trial (Amit Garg, MD, MA, FRCPC, FACP, PhD; Stephanie N. Dixon, PhD, MSc)
- Grand Rounds March 22, 2024: Early Diagnosis and Assessment of Autism Via Objective Measurements of Social Visual Engagement (Warren Jones, PhD)
- Grand Rounds March 15, 2024: Antibiotic Choice on Renal Outcomes – The ACORN Trial (Edward Qian, MD, MSc)
- Grand Rounds March 8, 2024: Public-Private Partnerships in the Trustworthy Health AI Ecosystem (Michael Pencina, PhD; Brian Anderson, MD)
- Grand Rounds March 1, 2024: Effect of an Intensive Food-As-Medicine Program on Health and Health Care Use: Evidence from a Randomized Clinical Trial (Joseph Doyle, PhD)
- Grand Rounds February 23, 2024: Virtual Vigilance: Monitoring of Decentralized Clinical Trials (Adrian Hernandez, MD; Christopher J. Lindsell, PhD)
- Grand Rounds February 16, 2024: Clinical Implications of the MINT Trial: p=0.07 (Jeffrey Carson, MD, MACP)
- Grand Rounds February 9, 2024: Pragmatic Recruitment of Underrepresented Groups – Experience From the Diuretic Comparison Project (Cynthia Hau, MPH)
- Grand Rounds February 2, 2024: Strategies for Improving Public Understanding of FDA and the Products It Regulates…Why Should We Care, and What Might We Do? (Susan C. Winckler, RPh, Esq)
- Grand Rounds January 26, 2024: Advancing the Safe, Effective and Equitable Use of AI in Healthcare (Mark Sendak, MD, MPP; Suresh Balu, MD, MBA)
- Grand Rounds January 19, 2024: Why Are Imaging RCTs Different? Lessons From Chest Pain Evaluation Trials (Pamela S. Douglas, MD, MACC, FASE, FAHA)
- Grand Rounds January 12, 2024: Design and Implementation of a Weighted Lottery to Equitably Allocate Scarce Covid-19 Resources (Erin K. McCreary, PharmD, BCIDP)
- Grand Rounds Biostatistics Series January 5, 2024: Methods for Handling Missing Data in Cluster Randomized Trials (Rui Wang, PhD; Moderator: Fan Li, PhD)
2023 Grand Rounds Archive
- Grand Rounds December 15, 2023: Diversifying Clinical Trials: A Path Forward (Roxana Mehran, MD, FACC, FAHA, MSCAI, FESC)
- Grand Rounds December 8, 2023: A Pragmatic Randomized Trial of the Jumpstart Intervention to Promote Communication about Goals of Care for Hospitalized Patients with Serious Illness (Ruth Engelberg, PhD; Erin Kross, MD; Robert Lee, MD, MS)
- Grand Rounds December 1, 2023: Guidelines for Design and Analysis of Stepped-Wedge Trials (James P. Hughes, PhD)
- Grand Rounds November 17, 2023: Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results from the Nudge Study (Michael Ho, MD, PhD; Sheana Bull, PhD)
- Grand Rounds November 3, 2023: The Perils and Pitfalls of Complex Clustering in Pragmatic Trials (Jonathan Moyer, PhD; Moderator: Andrea Cook, PhD)
- Grand Rounds October 27, 2023: Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial (Harlan M. Krumholz, MD, SM)
- Grand Rounds October 20, 2023: A National Initiative to Eliminate Hepatitis C in the United States – Why This Matters to Clinical Trialists (Rachael L. Fleurence, PhD, MSc; Joshua M. Sharfstein, MD)
- Grand Rounds August 11, 2023: The REMAP-CAP Adaptive Platform Trial: Recent Insights and Future Directions (Patrick Lawler, MD, MPH)
- Grand Rounds October 13, 2023: Incorporating Social Determinants of Health Into PCORnet (Keith Marsolo, PhD)
- Grand Rounds October 6, 2023: Hybrid Studies Should Not Sacrifice Rigorous Methods (David M. Murray, PhD; Moderator: Jonathan Moyer, PhD)
- Grand Rounds September 29, 2023: Navigating the Use of Patient-Reported Outcomes in Research and Practice: The PROTEUS Consortium (Claire Snyder, PhD; Norah Crossnohere, PhD; Anne Schuster, PhD)
- Grand Rounds September 22, 2023: Integrating Community Health Workers into Team-Based, Early Childhood Preventative Care (Tumaini Rucker Coker, MD, MBA)
- Grand Rounds September 15, 2023: Effect of Financial Incentives and Default Options on Food Choices of Adults With Low Income in Online Retail Settings (Pasquale Rummo, PhD, MPH)
- Grand Rounds September 8, 2023: The DEVICE Trial: An Embedded, Pragmatic Trial of Emergency Airway Management (Matthew Prekker, MD, MPH; Jonathan Casey, MD, MSc)
- Grand Rounds August 25, 2023: Pragmatic Trial of an EHR Application to Display Real-time PRO Data: Successes and Challenges (Gabriela Schmajuk, MD, MS)
- Grand Rounds August 18, 2023: Opportunities to Improve Clinical Trials: Draft Revision of the ICH Good Clinical Practice Guideline (E6R3) (Prof Sir Martin Landray, FMedSci; M. Khair ElZarrad, PhD, MPH)
- Grand Rounds July 21, 2023: Implementing New Care Pathways for Low Back Pain in Academic Healthcare Systems: Early Lessons from IMPACt-LBP (Christine Goertz, DC, PhD; Adam Goode, DPT, PhD)
- Grand Rounds August 4, 2023: AI & ML: Want to Play a Game? (Eric Perakslis, PhD)
- Grand Rounds July 28, 2023: How Can Researchers Fight Misinformation About Medicine? (Carl T. Bergstrom, PhD)
- Grand Rounds July 14, 2023: Lessons From the COORDINATE-Diabetes Trial (Christopher B. Granger, MD; Neha J. Pagidipati, MD, MPH)
- Grand Rounds March 3, 2023: Adoption, Implementation and Sustainment of Family-focused Prevention in Health Care Systems: How Do We Get There? (Margaret Kuklinski, PhD; Stacy Sterling, DrPH, MSW)
- Grand Rounds July 7, 2023: Implementing Virtual Strategies Across an Integrated Healthcare System: The IMPLEMENT-HF Study (Ankeet S. Bhatt, MD, MBA, ScM)
- Grand Rounds June 16, 2023: BeatPain Utah: Partnering With Community Health Centers Within a Socio-Technical Framework (Julie Fritz, PT, PhD, FAPTA; Guilherme Del Fiol, MD, PhD)
- Grand Rounds June 30, 2023: Decentralized Trials – From Guidance to Reality & What’s Left (Adrian Hernandez, MD, MHS; Pamela Tenaerts, MD, MPH; Craig Lipset, MPH)
- Grand Rounds June 23, 2023: Improving Delivery of Care for Chronic Kidney Disease, Diabetes and Hypertension (Miguel A. Vazquez, MD and George Oliver, MD, PhD)
- Grand Rounds June 9, 2023: Emulating Randomized Clinical Trials with Non-randomized Real-world Evidence Studies: Results From The RCT DUPLICATE Initiative (Shirley V. Wang, PhD)
- Grand Rounds June 2, 2023: PROACT Xa and The Wizard of Oz: Behind the Curtain of a Pragmatic Decentralized Clinical Trial (John Alexander, MD, MHS)
- Grand Rounds May 19, 2023: Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis After a Fracture (Robert O’Toole, MD)
- Grand Rounds May 12, 2023: Design and Pragmatic Trial of COACH: A Patient Portal/EHR Information System for Home Blood Pressure Monitoring in Hypertension (Richelle J. Koopman, MD, MS)
- Grand Rounds May 5, 2023: All of Us Research Program: Improving Health Through Diverse Technology, Huge Cohorts, and Precision Medicine (Joshua C. Denny, MD, MS)
- Grand Rounds April 28, 2023: Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation: An Embedded Cluster-crossover Trial (Matthew W. Semler, MD, MSc)
- Grand Rounds April 21, 2023: Personalised Cooler Dialysate for Patients Receiving Maintenance Haemodialysis (MyTEMP): A Pragmatic, Cluster-randomised Trial (Amit Garg, MD, MA, FRCPC, FACP, PhD; Stephanie N. Dixon, PhD MSc)
- Grand Rounds April 14, 2023: RECOVER in Action – Status of Clinical Trial Protocols (Kanecia Zimmerman, PhD, MD, MPH)
- Grand Rounds April 7, 2023: A Nudge Towards Cardiovascular Health: Incorporating Insights From Behavioral Science to Improve Cardiovascular Care Delivery (Srinath Adusumalli, MD, MSHP, MBMI, FACC)
- Grand Rounds March 24, 2023: From Observational Studies to Pragmatic Clinical Trials: (Almost) A Decade of Research in PCORnet® (Erin Holve, PhD, MPH, MPP; Russell Rothman, MD, MPP; Schuyler Jones, MD; Neha Pagidipati, MD, MPH)
- Grand Rounds March 17, 2023: Remote Symptom Monitoring with Electronic Patient-Reported Outcomes (ePROs) in Oncology (Ethan Basch, MD, MSc)
- Grand Rounds March 10, 2023: Estimands in Cluster-Randomized Trials: Choosing Analyses that Answer the Right Question (Brennan Kahan, PhD)
- Grand Rounds February 24, 2023: S2302 Pragmatica-Lung: New Directions for Decreasing Burden and Increasing Inclusion in NCTN Clinical Trials (Konstantin Dragnev, MD; Karen Reckamp, MD, MS)
- Grand Rounds February 17, 2023: The Heartline Trial: A New Paradigm in Conducting Virtual Clinical Trials (C. Michael Gibson, MS, MD)
- Grand Rounds Ethics and Regulatory Series February 10, 2023: Informing and Consenting: What Are the Goals? (P. Pearl O’Rourke, MD; David S. Wendler, PhD, MA; Miguel Vazquez, MD; P. Michael Ho, MD, PhD)
- Grand Rounds February 3, 2023: Pragmatic Trials For Children With Congenital Heart Disease – Insights From The NITRIC Trial (Luregn Schlapbach, PhD, FCICM)
- Grand Rounds January 27, 2023: The PREPARE II Trial: Embedding a Pragmatic Trial Into Clinical Care During an Emergency Procedure (Derek W. Russell, MD; Matthew W. Semler, MD, MSc)
- Grand Rounds January 20, 2023: Collaborative Pragmatic Trials in Action: EVOLVE-MI (Mikhail Kosiborod, MD)
- Grand Rounds Ethics and Regulatory Series January 13, 2023: Ethical Considerations When Vulnerable Populations are Subjects in Pragmatic Trials (Emily A. Largent, JD, PhD, RN)
- Grand Rounds January 6, 2023: Outpatient Treatment of COVID-19 With Metformin, Ivermectin, or Fluvoxamine: 10-Month Follow-up and Effects on Developing Long COVID (Carolyn Bramante, MD, MPH; Thomas Murray, PhD)
2022 Grand Rounds Archive
- Grand Rounds December 16, 2022: The Use of EHR-Agnostic Clinical Decision Support to Prevent Thromboembolism in Hospitalized Medically Ill Patients (Alex C. Spyropoulos, MD, FACP, FCCP, FRCPC; Jeffrey Solomon, BFA)
- Grand Rounds Ethics and Regulatory Series December 9, 2022: The Stepped Wedge Cluster Randomized Trial: Friend or Foe? (Monica Taljaard, PhD; David Magnus, PhD)
- Grand Rounds December 2, 2022: A Randomized Controlled Trial of Mobile Health Intervention in Heart Failure and Diabetes: Lessons Learned (G. Michael Felker, MD, MHS)
- Grand Rounds November 18, 2022: The FIRST-ABC Pragmatic Trials of Non-Invasive Respiratory Support In Children (Padmanabhan Ramnarayan, MBBS, MD, FRCPCH, FFICM)
- Grand Rounds Ethics and Regulatory Series November 11, 2022: Data Sharing and Pragmatic Clinical Trials: Law & Ethics Amidst a Changing Policy Landscape (Stephanie Morain, PhD, MPH; Kayte Spector-Bagdady, JD, MBioethics)
- Grand Rounds November 4, 2022: The CardioNerds Clinical Trials Network: Pairing Equitable Enrollment with Trainee Development (Amit Goyal, MD, MAS)
- Grand Rounds October 28, 2022: The HERO (Healthcare Worker Exposure Response & Outcomes) Program: An Online Community to Support Observational Studies, Randomized Trials, and Long-Term Safety Surveillance (Emily O’Brien, PhD, FAHA; Russell Rothman, MD, MPP)
- Grand Rounds October 21, 2022: Disinformation, Cyberthreat, and Choice: Protecting Patients and Clinical Research From the Digital Triple Threat (Eric Perakslis, PhD; Andrea Downing)
- Grand Rounds Ethics and Regulatory Series October 14, 2022: Responding (or Not) to Signals of Potential Clinical Significance in Pragmatic Clinical Trials (Joseph Ali, JD; Tanya Matthews, PhD; Leslie J. Crofford, MD)
- Grand Rounds October 7, 2022: Impact Of Handovers Of Anesthesia Care On Morbidity And Mortality (Melanie Meersch-Dini, MD)
- Grand Rounds September 30, 2022: CTTI’s Digital Health Trials Hub Recommendations and Resources to Run Your Digital Health Trial (Marianne Chase, MGH, CTTI Team Lead, Jörg Goldhahn, ETH Zurich, CTTI Team Lead)
- Grand Rounds September 23, 2022: Effect Of An Intensive Nurse Home Visiting Program On Adverse Birth Outcomes In A Medicaid-Eligible Population (Margaret McConnell, PhD)
- Grand Rounds September 16, 2022: Using Nationwide Registries to Conduct Pragmatic Randomized Trials: The DANFLU Program (Tor Biering-Sørensen, MD, PhD, MPH)
- Grand Rounds Ethics and Regulatory Series September 9, 2022: Building An Academic Learning Health System: Why Is It So Hard? (Steven Joffe, MD, MPH)
- Grand Rounds August 26, 2022: The Diuretic Comparison Project: A Large Pragmatic Clinical Trial (Areef Ishani, MD, MS)
- Grand Rounds August 19, 2022: Inclusion and Diversity in Clinical Trials: Actionable Steps to Drive Lasting Change (Gerald Bloomfield, MD, MPH; Michelle Kelsey, MD)
- Grand Rounds July 8, 2022: Results From the COVID-OUT Trial, A Phase-3 Trial of Outpatient Treatment for Covid-19 Using Metformin, Ivermectin, and Fluvoxamine (Carolyn Bramante, MD, MPH; Thomas Murray, PhD; Jared Huling, PhD)
- Grand Rounds August 12, 2022: Equitably Including Diverse Participants in Pragmatic Clinical Trials (Consuelo H. Wilkins, MD, MSCI)
- Grand Rounds August 5, 2022: Economic Evaluation of Platform Trial Designs (Jay JH Park, PhD, MSc)
- August 10, 2022: NIH Pragmatic Trials Collaboratory Announces Grand Rounds Series on Ethical and Regulatory Challenges in Pragmatic Trials
- Grand Rounds July 29, 2022: Effect of Early Treatment With Single-Dose Pegylated Interferon Lambda Among Patients With COVID-19: Results From The TOGETHER Trial (Edward Mills, PhD, FRCP; Jeffrey S. Glenn, MD, PhD)
- Grand Rounds July 22, 2022: ACTIV-6: 1-Year Later and Trial Results for Ivermectin-400 and Inhaled Fluticasone (Susanna Naggie, MD, MHS)
- Grand Rounds July 15, 2022: Overview of Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) Public-Private Partnership and Lessons Learned (Stacey J. Adam, PhD)
- June 24, 2022: FDA Draft Guidance on Real-World Evidence (John Concato, MD, MS, MPH)
- June 17, 2022: PREPARE: A Successful, Primarily Remote Pragmatic Trial in Black and Latinx Population with Asthma: Challenges and Successes (Elliot Israel, MD)
- June 10, 2022: Do We Really Need So Many Heart Failure Clinicians? (Tariq Ahmad, MD, MPH)
- June 3, 2022: Results of the MedSafer Study: Electronic Decision Support for Deprescribing in Hospitalized Older Adults (Emily G. McDonald MDCM, MSc, FRCPC)
- May 20, 2022: Long-COVID Studies Within the RECOVER Platform (Upinder Singh, MD)
- May 13, 2022: Ethics and Collateral Findings in Pragmatic Clinical Trials: Implications of a Multi-Method Exploration
- May 6, 2022: N-of-1 Randomized Trials: CRAVE and I-STOP-AFib as Examples (Gregory Marcus, MD, MAS)
- April 29, 2022: BP Track: National Surveillance for Blood Pressure Control and Related Process Metrics Using PCORnet (Mark J. Pletcher, MD, MPH; Rhonda Cooper-DeHoff, PharmD, MS; Alanna M. Chamberlain, PhD, MPH)
- April 15, 2022: SODIUM-HF: Should Our Patients Consume Less Dietary Sodium? (Justin A. Ezekowitz, MBBCh, MSc)
- April 8, 2022: COVID-19 Surveillance in PCORnet: Year 2 Update (Jason Block, MD, MPH; Thomas W. Carton, PhD, MS)
- January 21, 2022: Primary Palliative Care for Emergency Medicine (Corita R. Grudzen, MD, MSHS, FACEP)
- April 1, 2022: ICD-Pieces: Improving Care for CKD, Diabetes and Hypertension in Health Systems (Miguel A. Vazquez, MD; George (Holt) Oliver, MD, PhD)
- March 25, 2022: A Telehealth-Delivered Pragmatic Trial of Mindfulness for Persons with Chronic Low Back Pain (Natalia Morone, MD, MS)
- March 18, 2022: Early Treatment of COVID-19: The TOGETHER Adaptive Platform Trial (Edward Mills, PhD, FRCP; Craig Rayner, PharmD)
- March 11, 2022: Understanding a Patient’s Daily Experience Through Mobile Devices and Wearables: Lessons Learned From the 8,000 Patient MIPACT Study and Implementation in a National Pragmatic Trial (Sachin Kheterpal, MD, MBA; Jessica Golbus, MD; Nicole Pescatore, MPH)
- March 4, 2022: ACP COVID: A Trial to Evaluate an Advance Care Planning Video and Communication Skills Training Intervention for Older Adults During an Evolving Pandemic (Angelo E. Volandes, MD, MPH; James A. Tulsky, MD; Sophia N. Zupanc, BA)
- February 25, 2022: The Next Generation of Patient-Centered Trials – No Site Visits, Home-delivery of Meds and Patient-reported Outcomes – The CHIEF-HF Trial (John Spertus, MD, MPH, FACC, FAHA)
- February 18, 2022: Building a Resource: The Process of Developing a Trans-stakeholder Framework to Enable Pediatric Drug Development (Perdita Taylor-Zapata, MD)
- February 11, 2022: Great Power and Great Responsibility: Machine Learning in Clinical Research (E. Hope Weissler, MD, MHS; Erich Huang, MD, PhD)
- February 4, 2022: SPIRRIT-HFpEF: Opportunities and Challenges in a Large Registry-Based Randomized Clinical Trial(Adam DeVore, MD, MHS; Lars Lund, MD, PhD)
- January 28, 2022: EMBED Trial Results: Pragmatic Trial of User-Centered Clinical Decision Support to Implement Emergency Department-Initiated Buprenorphine for Opioid Use Disorder
- January 14, 2022: Searching for a Unicorn: Understanding Stakeholder Perspectives When Selecting Outcomes for Outpatient Trials (Christopher Lindsell, PhD)
- January 7, 2022: D-PRESCRIBE-AD: A Pragmatic Trial to Educate and Sensitize Caregivers and Healthcare Providers to Reduce Inappropriate Prescription Burden in Persons Living with Dementia (Jerry H. Gurwitz, MD; Richard Platt, MD, MSc)
- December 17, 2021: Cyberthreat, Cybersecurity and Cyber Compliance in Clinical Research and Healthcare: One Size Fits None (Eric Perakslis, PhD)
2021 Grand Rounds Archive
- December 10, 2021: Decentralized Trials: Naughty or Nice? (Adrian F. Hernandez, MD, MHS)
- December 3, 2021: Primary Care-Based Behavioral Treatment for Long Term Opioid Users with Chronic Pain: Primary Results and Lessons Learned from the PPACT Pragmatic Trial (Lynn DeBar, PhD MPH)
- November 19, 2021: Exploring Approaches in Using Digital and Mobile Health in Patient-oriented Research: Pearls and Pitfalls (Anish K. Agarwal MD, MPH MS)
- November 12, 2021: Using Financial Incentives to Increase COVID-19 Vaccine Uptake (Charlene Wong, MD MSHP; Noel T. Brewer, PhD)
- November 5, 2021: Benefits of Stroke Treatment Delivered Using a Mobile Stroke Unit Compared to Standard Management by Emergency Medical Services: The BEST-MSU Study (James C Grotta, MD)
- October 29, 2021: Embedding Pragmatic Trials into Emergency and Critical Care (Matthew W. Semler, MD, MSc; Jonathan D. Casey, MD, MSc)
- October 22, 2021: The STAMP Trial: Increasing Engagement in Advance Care Planning and Lessons Learned from Partnering with Community Ambulatory Practices (Terri R. Fried, MD)
- October 15, 2021: The Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in Bangladesh (Jason Abaluck, PhD)
- October 8, 2021: Lessons Learned and Patient Partnership in ADAPTABLE (Schuyler Jones, MD; Madelaine Faulkner Modrow, MPH)
- October 1, 2021: COVID-OUT: From Computer Modeling to a Phase III Trial of Early Outpatient Treatment for SARS-CoV-2 Infection (Carolyn Bramante, MD, MPH; Thomas Murray, PhD; Jared Huling, PhD)
- September 24, 2021: Enabling Patient-Reported Outcome Measures (PROMs) in Clinical Trials, Exemplified by Cardiovascular Trials (Theresa Coles, PhD; Kevin Weinfurt, PhD)
- September 17, 2021: Population-based Outreach to Prevent Suicidal Behavior: A Pragmatic Randomized Trial (Gregory Simon, MD, MPH; Susan M Shortreed, PhD)
- September 10, 2021: Effect of Salt Substitution on Cardiovascular Events and Death (Bruce Neal, MB ChB, PhD, FRCP, FAHA, FAHMS)
- August 27, 2021: Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock: the DOREMI trial (Benjamin Hibbert, MD, PhD)
- August 20, 2021: Fluvoxamine for Early Treatment of COVID-19: The STOP COVID Clinical Trials (Eric Lenze, MD)
- August 13, 2021: Got anything for this cough? Outpatient Treatment Trials in the Time of COVID (Davey Smith MD)
- August 6, 2021: Early Treatment of COVID-19 with Repurposed Therapies: The TOGETHER Adaptive Platform Trial (Edward Mills, PhD, FRCP)
- July 30, 2021: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Diversity in the PCT Ecosystem – How Do We Develop a Pipeline of Diverse Investigators and Leaders in PCTs? (Lesley Curtis, PhD; Marie A. Bernard, MD; George A. Mensah, MD, FACC; Natalia Morone, MD, MS)
- July 23, 2021: Long Term COVID Patient Engagement: Best Practices Informed By Patients’ Experiences Seeking Medical Care (Diana Berrent, JD; Natalie Lambert, PhD; Nick Guthe)
- July 16, 2021: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Maximizing Diversity in PCTs – What Can We Learn From Implementation Trials? (David Chambers, DPhil; Amanda Midboe, PhD; Anne Trontell, MD, MPH)
- July 9, 2021: COVID-19 Vaccine Efficacy Studies: Challenges and Successes (Hana El Sahly, MD)
- June 25, 2021: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Meeting Participants Where They Are – Outreach, Trust, and Consent to Maximize Diversity (Emily O’Brien, PhD; Jonathan Jackson, PhD; Judith Schlaeger, PhD; Stacy Sterling, DrPH)
- June 18, 2021: The MITIGATE Study: Insights from a Decentralized, Virtual, Electronic Health Record-Based Pragmatic Clinical Trial (Andrew Ambrosy, MD; Alan Go, MD)
- June 11, 2021: The TSOS Effectiveness-Implementation Hybrid Study: Health Care System Level Theoretical Considerations & Pragmatic Trial Results (Douglas Zatzick, MD)
- June 4, 2021: Inclusion of Diverse Participants in Pragmatic Clinical Trials: Planning for Diversity – Stakeholder Engagement and Site Selection to Maximize Diversity (Wendy Weber, ND, PhD, MPH; Julie Fritz, PhD, PT; David Wetter, PhD, MS; Gloria Coronado, PhD; Amanda Petrik, MS)
- May 21, 2021: The PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation in Trial Design and Delivery (Chris Butler, MD; Ben Saville, PhD)
- May 14, 2021: Keynote Session: Diverse Representation Among Clinical Trial Participants: Why It Is Important and How Can We Improve (Clyde W. Yancy, MD, MSc)
- May 7, 2021: Online Recruitment in the Era of COVID-19: Pitfalls and Progress (Megan L. Ranney, MD, MPH)
- April 30, 2021: ACTIV-6: COVID-19 Outpatient Randomized Trial to Evaluate Efficacy of Repurposed Medications (Susanna Naggie, MD, MHS; Elizabeth Shenkman, PhD)
- April 23, 2021: COVID Clinical Trials: The Intermountain Healthcare Experience (Samuel M. Brown, MD, MS)
- April 16, 2021: Minnesota EHR Consortium COVID-19 Project: A Statewide Collaboration to Inform Vaccine Equity (Paul E. Drawz, MD, MHS, MS; Tyler Winkelman, MD, MSc)
- April 9, 2021: Taking Research to the Participant: Experiences with TREAT NOW, a No-Touch COVID-19 Trial (Adit Ginde, MD, MPH)
- April 2, 2021: Lessons from COVID-19: The First Year of the REMAP-CAP Global Adaptive Platform Trial (Derek Angus, MD, MPH)
- March 26, 2021: The Path to Preventive Genomics (Robert C. Green, MD, MPH)
- March 19, 2021: HERO-Learning Together about Vaccines for SARS-CoV-2 (Emily O’Brien, PhD; Robert Califf, MD)
- March 12, 2021: Lessons Learned from the Gates MRI Virtual COVID-19 Trial (Mohamed Bassyouni, PharmD; Jintanat Ananworanich, MD, PhD)
- March 5, 2021: Data and Safety Monitoring Boards for Trials of COVID-19 Vaccines: The Challenges (Susan S. Ellenberg, PhD)
- February 26, 2021: Calibrating Real-World Evidence Against RCT Evidence: Early Learnings from RCT-DUPLICATE (Sebastian Schneeweiss, MD, ScD)
- February 19, 2021: Beyond Politics: Promoting COVID Vaccination in the United States (Kevin A. Schulman, MD)
- February 12, 2021: Leveraging RWD in a Multinational Trial: Results from the Other eHARMONY [HARMONY Outcomes EHR Ancillary Study] (Lesley Curtis, PhD, Bradley Hammill, PhD, Sudha Raman, PhD)
- February 5, 2021: Generating High-Quality Evidence During a Pandemic: The Brazilian COALITION Experience (Renato Lopes, MD, MHS, PhD)
- January 29, 2021: The COVID-19 Citizen Science Study (Gregory M. Marcus, MD, MAS)
- January 22, 2021: Is It Time to Embrace Preprints? A Conversation About the First 18 Months of medRxiv (Harlan Krumholz, MD, SM; Joseph Ross, MD, MHS)
- January 15, 2021: How CTTI & the Clinical Trials Community Have Risen to Meet the Challenge of the COVID-19 Pandemic (Pamela Tenaerts, MD, MBA; Sara Calvert, PharmD; Leanne Madre, JD, MHA)
- January 8, 2021: HERO-TOGETHER: Building Vaccine Confidence With Long-Term Outcomes Data (Emily O’Brien, PhD)
2020 Grand Rounds Archive
- December 18, 2020: The SAMSON Trial: An N-of-1 Trial of Statin, Placebo, and No Treatment to Assess Patient Symptoms (Matthew Shun-Shin, BMBCh, PhD)
- December 11, 2020: PREVENTABLE: Starting a Pragmatic Trial in a Pandemic (Karen Alexander, MD; Schuyler Jones, MD)
- December 4, 2020: The Yale New Haven Health System as an Evidence Generation Ecosystem for Heart Failure (Tariq Ahmad, MD, MPH)
- November 20, 2020: Drug Development in Kidney Disease: Proceedings from a Multi-Stakeholder Panel (Daniel Edmonston, MD)
- November 13, 2020: Pragmatic and Explanatory Attitudes to RCTs: Using the PRECIS-2 Tool to Describe the Design of the MyTEMP Trial (Ahmed Al-Jaishi, PhD; Amit Garg, MD, PhD, Merrick Zwarenstein, MBBCh, MSc, PhD)
- November 6, 2020: Appendectomy Versus Antibiotics for Appendicitis–Early Results from the CODA Trial (David R. Flum, MD, MPH)
- October 30, 2020: Lessons from Virtual Trials in Time of a Pandemic: Minnesota Hydroxychloroquine Experience (David Boulware, MD, MPH)
- October 23, 2020: Outpatient Clinical Decision Support – An Evidence-Based Implementation Framework (Patrick O’Connor, MD, MA, MPH; JoAnn Sperl-Hillen, MD)
- October 16, 2020: Back to School, It’s More Than Just a Trip to Target This Year: The ABC Science Collaborative (Danny Benjamin, MD, PhD; Kanecia Zimmerman, MD, MPH)
- October 9, 2020: Pragmatic Trial of Higher vs. Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis (HiLo) (Myles Wolf, MD)
- October 2, 2020: Driving Toward Health Impact: Our Journey and Path Forward (Nakela Cook, MD, MPH)
- September 25, 2020: Accelerating the Nation’s COVID-19 Testing Capacity: An Update from the NIH’s RADx Program (Rick Bright, PhD; Rachael Fleurence, PhD)
- September 11, 2020: Launching CONNECTS: Collaborating Network of Networks for Evaluating COVID-19 and Therapeutic Strategies (Gordon Bernard, MD; Sonia Thomas, DrPH)
- August 28, 2020: Designing, Conducting, Monitoring, and Analyzing Data from Pragmatic Clinical Trials: Proceedings from a Multi-Stakeholder Think Tank Meeting (Trevor Lentz, PT, PhD, MHA; Lesley Curtis, PhD; Frank Rockhold, PhD)
- August 21, 2020: Adaptive Platform Trials: Scalable from Breast Cancer to COVID (Laura Esserman, MD, MBA)
- August 14, 2020: Learning While Sprinting: A One-Year Retrospective from the NOHARM Pragmatic Trial (Jon Tilburt, MD; Andrea Cheville, MD)
- August 7, 2020: The Democratization of Medicine: Open Access, Social Media, AI, Apps, and Empowering the Patient as the Future of Clinical Research (C. Michael Gibson, MS, MD)
- July 31, 2020: Using Real-World Data to Plan Eligibility Criteria and Enhance Recruitment: Actionable Recommendations and Resources from the Clinical Trials Transformation Initiative (Sudha Raman, PhD, MA; John Sheehan, PhD, MBA, RPh)
- July 24, 2020: TENS in Fibromyalgia: From Fundamental Neurobiology to Pragmatic Trial (Leslie J. Crofford, MD; Kathleen Sluka, PT, PhD)
- July 17, 2020: Living Textbook Grand Rounds Series: Choosing What to Measure and Making it Happen: Your Keys to Pragmatic Trial Success (Devon Check, PhD; Rachel Richesson, PhD)
- July 10, 2020: COVID Open Science Collaborative Analytics Platform: National COVID Cohort Collaborative (N3C) (Ken Gersing, MD; Robert Star, MD)
- June 26, 2020: Advances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials: Keys to Success in the Evolving EHR Environment (Keith Marsolo, PhD; Teresa Zayas-Cabán, PhD; George (Holt) Oliver, MD, PhD; Christopher A. Longhurst, MD, MS; Rachel Richesson, PhD, MPH)
- June 19, 2020: Living Textbook Grand Rounds Series: Part 4-Demystifying Biostatistical Concepts for Embedded Pragmatic Clinical Trials (Elizabeth Turner, PhD; Patrick Heagerty, PhD; David Murray, PhD)
- June 12, 2020: A Cluster Randomized Pragmatic Trial of an Advance Care Planning Video Intervention in Long-Stay Nursing Home Residents: Main Findings from the PROVEN Trial (Susan Mitchell, MD, MPH)
- June 5, 2020: PCORnet COVID-19 Common Data Model Design and Results (Thomas Carton, PhD, MS; Keith Marsolo, PhD; Jason Perry Block, MD, MPH)
- May 29, 2020: Advances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials: Experiences from the Collaboratory PCTs (Wendy Weber, ND, PhD, MPH; Jerry Jarvik, MD, MPH; Lynn DeBar, PhD, MPH; Doug Zatzick, MD; Vince Mor, PhD)
- May 15, 2020: Optimized Learning While Doing: The REMAP-CAP Adaptive Platform Trial (Derek Angus, MD, MPH)
- May 8, 2020: Advances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials: Real World Evidence: Contemporary Experience and Future Directions (Patrick Heagerty, PhD, Jacqueline Corrigan-Curay, JD, MD, Joshua C. Denny, MD, MS)
- May 1, 2020: Advances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials: Keynote-Can the COVID-19 Crisis Lead to Reformation of the Evidence Generation Ecosystem? (Robert Califf, MD, MACC)
- April 24, 2020: The RECOVERY Trial: A UK National Platform Trial of Potential Treatments for Patients Hospitalised with COVID-19 (Martin Landray, PhD, FRCP)
- April 17, 2020: The HERO Program: PCORnet® at Work to Create a Healthcare Worker Community for Rapid Cycle Evidence (Nakela Cook, MD, MPH; Josie Briggs, MD; Susanna Naggie, MD; Emily O’Brien, PhD; Russell Rothman, MD; Chris Forrest, MD, PhD)
- April 10, 2020: Hydroxychloroquine for the Early Treatment of COVID-19 in Hospitalized Adults: A Multicenter Randomized Clinical Trial (Sean Collins, MD, MSc)
- April 3, 2020: Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): Participant-Centered, Rapidly-Deployed, Digitally-Enabled Research (Harlan Krumholz, MD; Bala Hota, MD, MPH; Graham Nichol, MD, MPH)
- March 27, 2020: Living Textbook Grand Rounds Series: Part 3-Tips for Putting Together a Successful PCT Grant Application (Wendy Weber, ND, PhD, MPH)
- March 20, 2020: Clinical Trials in the Time of COVID-19 (Susanna Naggie, MD; Adrian Hernandez, MD, MHS; Eric Perakslis, PhD)
- March 13, 2020: Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus–Lessons Learned and Future Directions (Abhinav Sharma, MD, PhD; Christopher Granger, MD)
- March 6, 2020: Creating a Learning Health System Through Randomization (Leora Horwitz, MD, MHS)
- February 28, 2020: Preparing for the Unknown: Conducting Pragmatic Research in Real-World Contexts
- February 21, 2020: Nudge Study Updates (Michael Ho, MD, PhD; Sheana Bull, PhD, MPH)
- February 14, 2020: Do Our Current Research Models Meet the Needs of a Learning Health Care System? (David Atkins, MD, MPH)
- February 7, 2020: Using Nudges to Improve the Delivery of Health Care (Mitesh S. Patel, MD, MBA)
- January 31, 2020: Living Textbook Grand Rounds Series Part 1: Pragmatic Clinical Trials: How Do I Start? (Lesley H. Curtis, PhD, Greg Simon, MD, MPH)
- January 24, 2020: Cardiovascular Trials Over 2 Decades: Progress on Pragmatism? (Justin A. Ezekowitz, MBBCh, MSc)
- January 17, 2020: Assessment of the Human Systemic Absorption of Sunscreen Active Ingredients: FDA-Sponsored Randomized Clinical Trial (Murali Matta, MPharm, PhD)
- January 10, 2020: Pragmatic Trials of Behavioral Economic Interventions to Increase Colorectal Cancer Screening (Shivan Mehta, MD, MBA)
2019 Grand Rounds Archive
- December 13, 2019: EMBED Update: Challenges and Solutions (Edward Melnick, MD, Gail D’Onofrio, MD)
- December 6, 2019: Millions More People, Stronger Collaborations: The New and Improved NIH Collaboratory Distributed Research Network (Richard Platt, MD, Kevin Haynes, PharmD, Denise Boudreau, PhD, Jerry Gurwitz, MD, Christopher Granger, MD)
- November 22, 2019: It’s Time to Learn From Patients Like Mine (Nigam H. Shah, MBBS, PhD)
- November 15, 2019: PCORnet: Health Plan Research Network Data Linkage and Patient Engagement with Patient-Powered Research Networks (Kevin Haynes, PharmD, MSCE)
- November 8, 2019: Lumbar Imaging with Reporting of Epidemiology: Initial Results and Some Lessons Learned (Jeffrey Jarvik, MD, MPH, Patrick Heagerty, PhD)
- November 1, 2019: NIH Collaboratory: Looking Back, Looking Forward (Adrian Hernandez, MD, MHS, Lesley Curtis, PhD, Kevin Weinfurt, PhD)
- October 25, 2019: Real-World Evidence for Drug Effectiveness Evaluation: Addressing the Credibility Gap (Richard Willke, PhD)
- October 18, 2019: Playing with FHIR–Innovative Use Cases for the New REDCap EHR Integration Module (Paul Harris, PhD)
- October 11, 2019: Objecting to Experiments that Compare Two Unobjectionable Policies or Treatments: Implications for Comparative Effectiveness and Other Pragmatic Clinical Trials (Michelle Meyer, PhD, JD)
- October 4, 2019: Ascertaining Death and Hospitalization Endpoints: The TRANSFORM-HF Experience (Eric Eisenstein, DBA, Kevin Anstrom, PhD)
- September 27, 2019: Preparing for Clinical Trial Data Sharing and Re-use: The New Reality for Researchers (Rebecca Li, PhD, Frank Rockhold, PhD)
- September 20, 2019: Designing & Testing the Future of Home-based Cervical Cancer Screening: Results from a Collaborative Academic-Embedded Delivery System Pragmatic Randomized Trial (Rachel L. Winer, PhD; Diana S.M. Buist, PhD, MPH)
- September 13, 2019: ADAPTABLE Recruitment and Follow-up: Health Plan Research Network Engagement (Kevin Haynes, PharmD, MSCE)
- September 6, 2019: Transforming Medical Evidence Generation with Technology-Enabled Trials (Matthew T. Roe, MD MHS)
- August 23, 2019: Oh Yes, We Have Tons of Patients Who Can Do This Study! (Vanita R. Aroda, MD)
- August 16, 2019: Introducing the Digital Medicine Society (Andy Coravos, MBA, Jen Goldsack, MS, MBA)
- August 9, 2019: Open Science: Are we there yet? (Adrian Hernandez, MD)
- August 2, 2019: AI and the Future of Psychiatry (Murali Doraiswamy, MBBS)
- July 26, 2019: Digital in Trials: Improving Participation and Enabling Novel Endpoints (Craig H. Lipset)
- July 19, 2019: Misinformation as a Source of Complication for Clinical Trials (Brian Southwell, PhD)
- July 12, 2019: medRxiv: A Paradigm Shift in Disseminating Clinical and Public Health Research (Harlan Krumholz, MD, SM, Joseph Ross, MD, MHS)
- June 28, 2019: Moving Beyond Return of Research Results to Return of Value (Consuelo Wilkins, MD, MSCI)
- June 21, 2019: A Polypill Strategy for Cardiovascular Prevention in Underserved Populations–Can We Bridge the Gap? (Daniel Munoz, MD, MPA, Thomas Wang, MD)
- June 14, 2019: Good Clinical Practice Guidance and Pragmatic Trials: Balancing the Best of Both Worlds in the Learning Health System (Robert Mentz, MD)
- June 7, 2019: In Dreams Begin Responsibilities: Data Science as a Service—Using AI to Risk Stratify a Medicare Population and Build a Culture (Erich Huang, MD, PhD)
- May 31, 2019: Adapting Clinical Trial Design to Meet the Needs of Learning Health Systems (Harriette Van Spall, MD, MPH)
- May 17, 2019: The VITamin D and OmegA-3 TriaL (VITAL): Design and Results of a Large Pragmatic Trial (JoAnn E. Manson, MD, DrPH)
- May 10, 2019: Treating Data as an Asset: Data Entrepreneurship in the Service of Patients (Eric Perakslis, PhD)
- May 3, 2019: Effect of Financial Bonus Sizes, Loss Aversion, and Increased Social Pressure on Physician Pay-for-Performance: A Randomized Trial and Cohort Study (Amol Navathe, MD, PhD)
- April 26, 2019: The VERITAS Trial: Virtual Exercise Rehabilitation at the Intersection of Evidence, Implementation, and Policy (Janet Prvu Bettger, ScD)
- April 19, 2019: Trauma Survivors Outcomes & Support (TSOS) Pragmatic Trial: Revisiting Effectiveness & Implementation Aims (Doug Zatzick, MD)
- April 12, 2019: Development of Harmonized Outcome Measures for Use in Research and Clinical Practice (Richard Gliklich, MD, Michelle Leavy, MPH, Elise Berliner, PhD)
- April 5, 2019: The ENGAGES Pragmatic Trial and the Power of Negative Thinking (Michael S. Avidan, MBBCh)
- March 29, 2019: ICD-Pieces: Lessons Learned in an Ongoing Trial (Miguel Vazquez, MD, George (Holt) Oliver, MD, PhD)
- March 22, 2019: Envisioning Data Liquidity – The Pew Data Interoperability Project (James E. Tcheng, MD)
- March 15, 2019: Leveraging RWE to Support Regulatory Decisions–An Update on Efforts to Inform Policy (Gregory W. Daniel, PhD, MPH, RPh)
- March 8, 2019: Dietary Trials in Heart Failure: SODIUM-HF (Justin Ezekowitz, MBBCh, MSc)
- March 1, 2019: Approaches to Patient Follow-Up for Clinical Trials: What’s the Right Choice for Your Study? (Keith Marsolo, PhD)
- February 22, 2019: Going from a Learning Health System to Learning Health Units: Opportunities and Challenges (Adrian Hernandez, MD, MHS)
- February 15, 2019: Improving Qualification of Investigators: Recommendations from the Clinical Trials Transformation Initiative (Christine M. Hildebrand, PA-C, Janette Panhuis)
- February 8, 2019: Paramedic Airway Management in Out-of-Hospital Cardiac Arrest – The Pragmatic Airway Resuscitation Trial (PART) (Henry Wang, MD, MS)
- February 1, 2019: Promoting Effective Advance Care Planning Communication in the Elderly: The ACP-PEACE Trial (James Tulsky, MD, Angelo Volandes, MD, MPH)
- January 25, 2019: A Learning Health System Story: Perinatal Outcomes Associated with a Major Change in Gestational Diabetes Screening (Sascha Dublin, MD, PhD, Gaia Pocobelli, PhD)
- January 18, 2019: Pragmatic Trials in End-stage Renal Disease (ESRD): HiLo (Myles Wolf, MD, MMSc)
- January 11, 2019: Nudge: Text Messaging at Scale in Diverse Health Systems to Support Adherence to Cardiac Medication (Sheana Bull, PhD, MPH, Michael Ho, MD, PhD)
- January 4, 2019: TRANSFORMing Research for Patients With Heart Failure (Robert Mentz, MD, Kevin Anstrom, PhD, Eric Eisenstein, DBA, Stephen Greene, MD, Eric Velazquez, MD)
2018 Grand Rounds Archive
- December 14, 2018: Guiding Good Choices for Health (GGC4H): Testing Feasibility and Effectiveness of Universal Parent-Focused Prevention in Three Healthcare Systems (Richard F. Catalano, PhD, Margaret Kuklinski, PhD, Stacy Sterling, DrPH, MSW)
- December 7, 2018: Cluster Randomized Trials in Health Care Delivery Systems: Lessons from STIC2IT (Niteesh K. Choudhry, MD, PhD)
- November 30, 2018: Validating a Computable Phenotype: Should Results Change a Trial’s Pre-Specified Primary Outcome? (Gregory E. Simon, MD, MPH, Susan M. Shortreed, PhD)
- November 16, 2018: Primary Palliative Care for Emergency Medicine (PRIM-ER) (Corita Grudzen, MD, MSHS)
- November 9, 2018: Data Linkage Within, Across, and Beyond PCORnet (Thomas W. Carton, PhD, MS, Keith Marsolo, PhD)
- November 2, 2018: EMBED Pragmatic Trial of User-Centered Clinical Decision Support to Implement Emergency Department-Initiated Buprenorphine for Opioid Use Disorder (Ted Melnick, MD, Gail D’Onofrio, MD)
- October 26, 2018: Making Measurements Meaningful (Brian J. Zikmund-Fisher, PhD)
- October 19, 2018: A New Path Forward for Using Decentralized Clinical Trials (Jeffry Florian, PhD, Annemarie Forrest, Penny Randall, MD, MBA)
- October 12, 2018: MDEpiNet RAPID and SPEED Projects: Leveraging Real World Evidence to Get Better, Faster, Cheaper Medical Devices for Physicians and Patients (Renee Mitchell, MT, CLS, Terrie Reed, MSIE, Roseann White, MA)
- September 28, 2018: Assessing and Reducing Risk of Re-identification When Sharing Sensitive Research Datasets (Greg Simon, MD, MPH, Deven McGraw, JD, MPH, Khaled El Emam, PhD)
- September 21, 2018: Returning Individual Research Results to Participants: Guidance for a New Research Paradigm (Jeffrey Botkin, MD, MPH, Consuelo Wilkins, MD, MSCI)
- September 14, 2018: Advancing the Use of Mobile Technologies for Data Capture & Improved Clinical Trials (John Hubbard, PhD, Barry Peterson, PhD, Cheryl Grandinetti, PharmD)
- September 7, 2018: NIH Collaboratory: Research Transformation in Progress (Adrian Hernandez MD, MHS, Kevin Weinfurt, PhD, Lesley Curtis, PhD)
- August 24, 2018: FoodSwitch USA: A Mobile Platform for Packaged Food Surveillance and Behavioral Research (Mark Huffman, MD, MPH)
- August 17, 2018: The PCORnet Bariatric Study: Preliminary Results from a Large PCORnet NIH Collaboratory (David Arterburn, MD, MPH, Kathleen McTigue, MD, MPH, Neely Williams, Mdiv, Laura Rasmussen-Torvik, PhD)
- August 10, 2018: Using a Novel mHealth Platform to Obtain Real-World Data for Post-Market Surveillance: A NEST NIH Collaboratory Trial (Sanket Dhruva, MD, MHS)
- August 3, 2018: A Digital Pragmatic Direct-to-Participant Clinical Trial for Identifying Underdiagnosed Atrial Fibrillation in a Large Health Plan Population (Steven Steinhubl, MD)
- July 27, 2018: Pilot Study for a Pragmatic Trial Comparing Chlorthalidone and Hydrochlorothiazide: Results and Lessons Learned (Karen Margolis, MD, MPH, Steven Fortmann, MD)
- July 20, 2018: Developing Technology-Derived Novel Endpoints for Use in Clinical Trials: Recommendations and Case Examples from the Clinical Trials Transformation Initiative (Will Herrington, MA, MBBS, MD, MRCP, Rob DiCicco, PharmD, Jen Goldsack, MA, MBA, OLY)
- July 13, 2018: Clinical Trial Data Sharing: Perspectives from Participants and PCORI (Michelle M. Mello, JD, PhD, Steven Goodman, MD, MHS, PhD)
- June 29, 2018: Policy & Priorities: Rethinking University Research with State Data (Aaron McKethan, PhD)
- June 22, 2018: Pragmatic Trial Design to Study Health Policy Interventions: Lessons Learned From ARTEMIS (Tracy Wang, MD, MHS, MSc)
- June 15, 2018: Research at Scale – Exploring What is Possible with High-Quality Real-World Data. Examples from Flatiron Health. (Amy P. Abernethy MD, MPH)
- June 8, 2018: Implementation in the PROVEN Trial: Challenges of Conducting PCTs in Nursing Home Health Care Systems (Susan Mitchell, MD, MPH; Angelo Volandes, MD, MPH)
- June 1, 2018: How Would You Build an Academic Medical System to Bridge Research and Care if You Could Start from Scratch?
- May 18, 2018: The PCORnet Antibiotics and Childhood Growth Study: Using PCORnet Data for Longitudinal Observational Research
- May 11, 2018: Launching the NESTcc Data Network to Improve the use of Real-World Evidence in the Medical Device Ecosystem
- May 4, 2018: Leveraging Community Engagement and Informatics-Based Tools to Increase Participant Recruitment and Retention
- April 27, 2018: Expanding Use of Real-World Evidence: A National Academies Workshop Series
- April 20, 2018: The Trauma Survivors Outcomes and Support (TSOS) Trial as an ePCT Training Case Study
- April 13, 2018: OHDSI: Drawing Reproducible Conclusions from Observational Clinical Data
- April 6, 2018: Legal and Ethical Architecture for PCOR Data
- March 30, 2018: HHS-DoD-VA Pain Management Collaboratory
- March 23, 2018: Data Science in the Era of Data Ubiquity
- March 16, 2018: Straight from the Source: Clinicians’ Views on Participating in CER/PCOR
- March 9, 2018: Closing the Loop in Research/Care-Delivery Partnerships: Communication and Dissemination in Learning Health Systems
- March 2, 2018: Distributed Research Network Querying: A Status Report
- February 23, 2018: Direct Mail Programs Work… But Will Health Centers Implement Them? Findings from STOP CRC
- February 16, 2018: Considerations for the Return of Genomic Results
- February 9, 2018: Linking Design to Analysis of Cluster Randomized Trials: Covariate Balancing Strategies
- February 2, 2018: Early Progress on the All of Us Research Program
- January 26, 2018: The Lumbar Imaging with Reporting of Epidemiology (LIRE) Trial: Subsequent Cross-Sectional Imaging Through 90 Days—Preliminary Results
- January 19, 2018: The Healthcare Pivot: Technology and Transformation of Healthcare
- January 12, 2018: Behavioral Economic Principles to Understand and Change Clinician Behavior
- January 5, 2018: IMPACT-AFib: An 80,000 Person Randomized Trial Using the Sentinel Initiative Platform
2017 Grand Rounds Archive
- December 15, 2017: Does Machine Learning Have a Place in a Learning Health System?
- December 8, 2017: Data and Safety Monitoring in Pragmatic Clinical Trials
- December 1, 2017: Providing a Shared Repository of Detailed Clinical Models for All of Health and Healthcare
- November 17, 2017: ICD-Pieces: From Planning to Performance
- October 27, 2017: Bringing Machine Learning to the Point of Care to Improve Suicide Prevention
- October 20, 2017: Automated Public Health Surveillance Using Electronic Health Record Data
- October 13, 2017: Users’ Guide for Integrating Patient-Reported Outcomes in Electronic Health Records
- October 6, 2017: Health Is More Than Healthcare
- September 29, 2017: Preprints: What, Why Not, and How
- September 22, 2017: Improving Evidence Generation for Medical Devices: The New National Evaluation System for Health Technology (NEST)
- September 15, 2017: Who to Include in a Pragmatic Trial? It Depends
- September 8, 2017: Leveraging Informatics in Pragmatic Research: Initial Experience in PCORnet
- August 25, 2017: Thoughts From the Phenotypes, Data Standards & Data Quality Core
- August 18, 2017: Behavioral Economics: A Versatile Tool for Clinical Research – From Interventions to Participant Engagement
- August 11, 2017: Embedding Clinical Trials Into Care Delivery: The Vanderbilt Experience
- August 4, 2017: PCORnet Research Innovations: Engagement, Dissemination, and (Hopefully) Tech Transfer Pilots
- July 28, 2017: The DSMB Role in Pragmatic Trials: NIMH Progress and Challenges
- July 21, 2017: CTTI Registry Trials Project: Evaluation and Design of Registries for Conducting Clinical Trials
- July 14, 2017: Leveraging Electronic Health Data in a Multinational Clinical Trial: Early Learnings from the HARMONY-Outcomes EHR Ancillary Study
- July 7, 2017: Ethics and the Precision Medicine Initiative: Reflections from Working on the Central PMI IRB
- June 30, 2017: The Yale Open Data Access (YODA) Project: Lessons Learned in Data Sharing
- June 23, 2017: The Sentinel System: A Case for Analysis Ready Data
- June 16, 2017: Project Baseline: Rationale, Design, and Progress
- June 9, 2017: ADAPTABLE, the Aspirin Study: Embracing Patient-Partnered Research
- June 2, 2017: PCORnet Health Plan Research Networks (HPRN): Data Linkage Activities to Facilitate Longitudinal Pragmatic and Observational CER
- May 19, 2017: Trial Innovation Network and PCORnet: Collaborations and Synergies
- May 12, 2017: Pragmatic Clinical Trials and Learning Health Care Systems: Strategies to Facilitate Implementation of Results into Clinical Care
- May 5, 2017: The SUPPORT, BOOST II, and COT Trials
- April 28, 2017: Perspective on the Boundary Between Quality Improvement Studies and Research
- April 21, 2017: Testing New Models of Research Funding
- April 14, 2017: Toward National Trauma Care Practice Change for PTSD and Comorbidity
- April 7, 2017: Healthy Hearts Northwest
- March 31, 2017: FDA and Pragmatic Trials
- March 24, 2017: Patient-Reported Outcomes
- March 17, 2017: Establishing the National Evaluation System for Health Technology (NEST) Coordinating Center
- March 10, 2017: Implementing PROVEN (Pragmatic Trial of Video Education in Nursing Homes)
- March 3, 2017: Showcasing Innovative Operational and Recruitment Approaches in the ADAPTABLE Trial
- February 24, 2017: Where Are We On Our Path to Digital Healthcare (And Why Is It So Hard?)
- February 17, 2017: Healthier Together
- February 10, 2017: INVESTED Vanguard Year
- February 3, 2017: A Tentative Introduction to the Revised Common Rule for the Protection of Human Subjects
- January 27, 2017: Connecting the Dots
- January 20, 2017: What “High Utilizers” Can Tell Us About Population Health
- January 13, 2017: What’s Next: People-Powered Knowledge Generation from Digital Data
- January 6, 2017: 21st Century Cures Overview and Implications
2016 Grand Rounds Archive
- December 16, 2016: Comparison of Different Approaches for Notification and Authorization in Pragmatic Clinical Research Evaluating Commonly Used Medical Practices
- December 9, 2016: Data Sharing in Pragmatic Trials
- December 2, 2016: Lessons Learned from the NIH Collaboratory Biostatistics and Design Core
- November 18, 2016: Lumbar Imaging with Reporting of Epidemiology (LIRE)
- November 11, 2016: Recommendations from the Clinical Trials Transformation Initiative’s Data Monitoring Committee Project
- November 4, 2016: Colorectal Cancer Screening in Primary Care: A Focus on STOP CRC
- October 28, 2016: Research on Medical Practices
- October 21, 2016: Demographics, Subgroup Analyses, and Statistical Considerations in Cluster-Randomized Trials
- October 14, 2016: Multidisciplinary Chronic Pain Management in Primary Care
- October 7, 2016: Chlorthalidone Versus Hydrochlorothiazide
- September 30, 2016: Dig If You Will the Picture of the NIH Collaboratory
- September 23, 2016: ICD-Pieces: Early Implementation and Progress
- September 16, 2016: PCORnet Building Trustworthiness
- September 9, 2016: Million Veteran Program
- August 26, 2016: Update from the Phenotypes, Data Standards, and Data Quality Core of the NIH Health Care Systems Research Collaboratory
- August 19, 2016: Privacy and Confidentiality in Pragmatic Clinical Trials
- August 12, 2016: Sharing Data: Methods to Increase Data Sharing and Improve Human Health
- August 5, 2016: Embedded Pragmatic Clinical Trials
- July 29, 2016: Accessing PCORnet’s Data and Network Resources
- July 22, 2016: Preparing for a Pragmatic Influenza Vaccine Clinical Trial
- July 15, 2016: FDA and Pragmatic Clinical Trials of Marketed Medical Products
- July 8, 2016: Mobile Health Data for Clinical and Health Systems Research
- June 24, 2016: Recommendations for Recruitment
- June 17, 2016: Oversight on the Borderline
- June 10, 2016: Pragmatic Trials in Dialysis
- June 3, 2016: CTSA Trial Innovation Network
- May 20, 2016: Altered Informed Consent in Pragmatic Clinical Trials
- May 13, 2016: ABATE Infection Trial
- May 6, 2016: Clinician Engagement in the NIH Collaboratory and Beyond
- April 29, 2016: PCORnet and CTSA Network
- April 22, 2016: Challenges and Opportunities for Using Common PRO Measures in Comparative Effectiveness Research
- April 15, 2016: Considerations in the Evaluation and Determination of Minimal Risk in Research Studies
- April 8, 2016: The Trauma Survivors Outcomes and Support (TSOS) Pragmatic Trial Targeting PTSD and Comorbidity
- April 1, 2016: Leveraging EHR Data to Evaluate Sepsis Guidelines
- March 18, 2016: Ethical Responsibilities Toward Indirect and Collateral Participants in Pragmatic Clinical Trials (PCTs)
- March 11, 2016: Uses of the NIH Collaboratory Distributed Research Network
- March 4, 2016: Patient-Focused Benefit-Risk Assessment
- February 26, 2016: Pragmatic Trials in Nursing Homes
- February 19, 2016: Harms, Benefits, and the Nature of Interventions in Pragmatic Clinical Trials
- February 12, 2016: Salford Lung Study
- February 5, 2016: Developing a Participant-Centric Consent Process for ADAPTABLE
- January 29, 2016: Patient Compensation