Accounting for Residual Confounding in the Analysis

Analysis Plan

Section 4

Accounting for Residual Confounding in the Analysis


Elizabeth R. DeLong, PhD

For the NIH Health Care Systems Collaboratory Biostatistics and Study Design Core


Contributing Editor

Jonathan McCall, MS

Despite incorporating design-based control for confounding, such as stratification, pair-matching, or constrained randomization, it is sometimes advisable to also include in the analysis covariates that might still be unbalanced across the arms of the study. Depending on the goals of the study, these covariates might be at the cluster level or even at the individual level. However, depending on the sample size, the number of covariates might be very limited.

When the number of clusters is small, permutation tests might be recommended. Again, the study statistician, in collaboration with the investigators, will determine the appropriate design and analysis methods.




DeLong ER. Analysis Plan: Accounting for Residual Confounding in the Analysis. In: Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials. Bethesda, MD: NIH Health Care Systems Research Collaboratory. Available at: Updated August 24, 2017.